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The Serological Specificity of Lens Alpha-Crystallin

The Serological Specificity of Lens Alpha-Crystallin Abstract Uhlenhuth (1903)1 was the first to recognize that lens proteins of all vertebrate classes share some common antigenic groups. This property of lens tissue is referred to as organ specificity. For many other tissues, however, species specificity predominates and cross-reactions occur only among closely related animals. Of the different lens proteins α-crystallin is generally regarded as showing the greatest degree of organ specificity.2,3 Furthermore, the immunoelectrophoretic studies of Manski et al,4 using anti-human cataract serum, revealed that the decreasing number of cross-reactions with nonmammalian lenses involved only the β- and γ-crystallins, except in the case of fish where it involved α-crystallin as well. The latter observation suggests that α-crystallin has undergone some change during evolution. The data reported in this study using antisera specific for lens α-crystallin will show that this conservative protein has indeed been modified at each class level of the phylogenetic scale. Materials and References 1. Uhlenhuth, P. T.: Zur Lehre von der Unterscheidung verschiedener Eiweissarten mit Hilfe spezifischer Sera , in Koch Festschrift, Jena: Gustav Fischer Verlag, 1903, p 49. 2. François, J., et al: Study of Antigens of Crystallin Lens, by Immunochemical Methods of Protein Fractionation , Amer J Ophthal 42:577 (Oct, (pt 1) ) 1956. 3. Maisel, H., and Langman, J.: Lens Proteins in Various Tissues of Chick Eye and in Lens of Animals Throughout Vertebrate Series , Anat Rec 140:183, 1961.Crossref 4. Manski, W.; Auerbach, T. P.; and Halbert, S. P.: Evolutionary Significance of Lens Organ Specificity , Amer J Ophthal 50:985, 1960. 5. Maisel, H., and Langman, J.: Immuno-Embryological Study on Chick Lens , J Embryol Exp Morph 9:191, 1961. 6. Goodman, M.: Evolution of Immunologic Species Specificity of Human Serum Proteins , Human Biol 34:104, 1962. 7. Maisel, H.: Lens Antigens in Ocular Tissues: Immunoelectrophoretic Study , Arch Ophthal 68: 254, 1962.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

The Serological Specificity of Lens Alpha-Crystallin

MAISEL, HARRY
Archives of Ophthalmology , Volume 72 (6) – Dec 1, 1964
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References (7)

Publisher
American Medical Association
Copyright
Copyright © 1964 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1964.00970020831019
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Abstract

Abstract Uhlenhuth (1903)1 was the first to recognize that lens proteins of all vertebrate classes share some common antigenic groups. This property of lens tissue is referred to as organ specificity. For many other tissues, however, species specificity predominates and cross-reactions occur only among closely related animals. Of the different lens proteins α-crystallin is generally regarded as showing the greatest degree of organ specificity.2,3 Furthermore, the immunoelectrophoretic studies of Manski et al,4 using anti-human cataract serum, revealed that the decreasing number of cross-reactions with nonmammalian lenses involved only the β- and γ-crystallins, except in the case of fish where it involved α-crystallin as well. The latter observation suggests that α-crystallin has undergone some change during evolution. The data reported in this study using antisera specific for lens α-crystallin will show that this conservative protein has indeed been modified at each class level of the phylogenetic scale. Materials and References 1. Uhlenhuth, P. T.: Zur Lehre von der Unterscheidung verschiedener Eiweissarten mit Hilfe spezifischer Sera , in Koch Festschrift, Jena: Gustav Fischer Verlag, 1903, p 49. 2. François, J., et al: Study of Antigens of Crystallin Lens, by Immunochemical Methods of Protein Fractionation , Amer J Ophthal 42:577 (Oct, (pt 1) ) 1956. 3. Maisel, H., and Langman, J.: Lens Proteins in Various Tissues of Chick Eye and in Lens of Animals Throughout Vertebrate Series , Anat Rec 140:183, 1961.Crossref 4. Manski, W.; Auerbach, T. P.; and Halbert, S. P.: Evolutionary Significance of Lens Organ Specificity , Amer J Ophthal 50:985, 1960. 5. Maisel, H., and Langman, J.: Immuno-Embryological Study on Chick Lens , J Embryol Exp Morph 9:191, 1961. 6. Goodman, M.: Evolution of Immunologic Species Specificity of Human Serum Proteins , Human Biol 34:104, 1962. 7. Maisel, H.: Lens Antigens in Ocular Tissues: Immunoelectrophoretic Study , Arch Ophthal 68: 254, 1962.Crossref

Journal

Archives of Ophthalmology – American Medical Association

Published: Dec 1, 1964

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