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Quinine Amblyopia

Quinine Amblyopia Abstract Introduction The problem of quinine amblyopia is over a century old. Its recognition and clinical description actually predate ophthalmoscopy.1 The literature on quinine amblyopia has been periodically reviewed, and the clinical course of this disease has been fully described by many authors.1-5 All emphasize the importance of individual susceptibility as well as total dosage. Although synthetic drugs have largely replaced quinine in the treatment of malaria over the past 20 years, patients with quinine amblyopia are still occasionally seen.5-18 The most frequently reported cause during the past 20 years is attempted abortion.5-14Recent reports of patients with quinine amblyopia have described the elecroretinogram (ERG) changes during the course of this disease.12-14 The ERG is normal in the acute stage when the visual fields are severely constricted, visual acuity reduced, and retina edematous. As the field expands and the optic disc becomes atrophic, the ERG response References 1. De Schweinitz, G. E.: The Toxic Amblyopias , Philadelphia, Lea Bros. and Co., 1896, pp 178-204. 2. Elliot, R. H.: Quinine Poisoning, Its Ocular Lesions and Visual Disturbances , Amer J Ophthal 1:541-560, 650-658, 1918. 3. Walsh, F. B.: Clinical Neuro-Ophthalmology , ed 2, Baltimore: The Williams & Wilkins Company, 1957 pp 1228-1229. 4. Grant, W. M.: Toxicology of the Eye, 1962 , Springfield, Ill: Charles C. Thomas, Publisher, 1962 pp 452-455. 5. Almeida, H.: Quinine Amblyopia , Quart Bull Northwest Univ Med Sch 35:217-222, 1961. 6. Dejean, C.; Viallefont, H.; and Boudent, C.: Un cas d' intoxication par la quinine , Bull Soc Ophtal Franc 2:184-187, 1958. 7. Glick, L., and Mumford, J.: Quinine Amblyopia: Treatment by Stellate Ganglion Block , Brit Med J 2:94-96, 1955.Crossref 8. Koeppe, H. W.: Severe Quinine Poisoning With Temporary Blindness , Ther Gegenw 95:148-149, 1956 9. abstracted, Ophthal Lit 10:856, 1956. 10. McLenachan, J.: Quinine Amblyopia Treated by Stellate Ganglion Block , Brit J Ophthal 47:62-63, 1963.Crossref 11. Redslob, E.; Warter, J.; and Isch, F.: Intoxication par la quinine , Ann Oculist 179:218-220, 1946. 12. Salomaa, S.: Case of Blindness Due to Quinine Toxicosis, Transactions of the Finnish Ophthalmological Society, 1949 , in Acta Ophthal (Kobenhavn) 31:180, 1953. 13. Barsky, D.: Quinine Idiosyncrasy and Optic Atrophy , J Mich Med Soc 60:612-613, 1961. 14. Berggren, L., and Rendahl, I.: Quinine Amblyopia: Report of 4 Cases, 2 of Them Studied With Electroretinography , Acta Ophthal (Kobenhavn) 33:217-228, 1955.Crossref 15. Vaino-Mattila, B., and Zewi, M.: Quinine Amblyopia and the ERG , Acta Ophthal (Kobenhavn) 32:451-461, 1954.Crossref 16. Bishay, A.: Quinine Amhlyopia , Brit J Ophthal 30:281-287, 1946.Crossref 17. Braverman, B. L.; Korowsky, D. S.; and Kulvin, M. M.: Quinine Amaurosis , Amer J Ophthal 31:731-733, 1948. 18. Lincoff, M. H.: Quinine Amblyopia , AMA Arch Ophthal 53:382-384, 1955.Crossref 19. Turtz, C. A.: Transient Loss of Vision Following Use of Quinine , Amer J Ophthal 44:110-111, 1957. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Quinine Amblyopia

BARD, LESLIE A.; GILLS, JAMES P.
Archives of Ophthalmology , Volume 72 (3) – Sep 1, 1964
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References (8)

Publisher
American Medical Association
Copyright
Copyright © 1964 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1964.00970020328007
Publisher site
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Abstract

Abstract Introduction The problem of quinine amblyopia is over a century old. Its recognition and clinical description actually predate ophthalmoscopy.1 The literature on quinine amblyopia has been periodically reviewed, and the clinical course of this disease has been fully described by many authors.1-5 All emphasize the importance of individual susceptibility as well as total dosage. Although synthetic drugs have largely replaced quinine in the treatment of malaria over the past 20 years, patients with quinine amblyopia are still occasionally seen.5-18 The most frequently reported cause during the past 20 years is attempted abortion.5-14Recent reports of patients with quinine amblyopia have described the elecroretinogram (ERG) changes during the course of this disease.12-14 The ERG is normal in the acute stage when the visual fields are severely constricted, visual acuity reduced, and retina edematous. As the field expands and the optic disc becomes atrophic, the ERG response References 1. De Schweinitz, G. E.: The Toxic Amblyopias , Philadelphia, Lea Bros. and Co., 1896, pp 178-204. 2. Elliot, R. H.: Quinine Poisoning, Its Ocular Lesions and Visual Disturbances , Amer J Ophthal 1:541-560, 650-658, 1918. 3. Walsh, F. B.: Clinical Neuro-Ophthalmology , ed 2, Baltimore: The Williams & Wilkins Company, 1957 pp 1228-1229. 4. Grant, W. M.: Toxicology of the Eye, 1962 , Springfield, Ill: Charles C. Thomas, Publisher, 1962 pp 452-455. 5. Almeida, H.: Quinine Amblyopia , Quart Bull Northwest Univ Med Sch 35:217-222, 1961. 6. Dejean, C.; Viallefont, H.; and Boudent, C.: Un cas d' intoxication par la quinine , Bull Soc Ophtal Franc 2:184-187, 1958. 7. Glick, L., and Mumford, J.: Quinine Amblyopia: Treatment by Stellate Ganglion Block , Brit Med J 2:94-96, 1955.Crossref 8. Koeppe, H. W.: Severe Quinine Poisoning With Temporary Blindness , Ther Gegenw 95:148-149, 1956 9. abstracted, Ophthal Lit 10:856, 1956. 10. McLenachan, J.: Quinine Amblyopia Treated by Stellate Ganglion Block , Brit J Ophthal 47:62-63, 1963.Crossref 11. Redslob, E.; Warter, J.; and Isch, F.: Intoxication par la quinine , Ann Oculist 179:218-220, 1946. 12. Salomaa, S.: Case of Blindness Due to Quinine Toxicosis, Transactions of the Finnish Ophthalmological Society, 1949 , in Acta Ophthal (Kobenhavn) 31:180, 1953. 13. Barsky, D.: Quinine Idiosyncrasy and Optic Atrophy , J Mich Med Soc 60:612-613, 1961. 14. Berggren, L., and Rendahl, I.: Quinine Amblyopia: Report of 4 Cases, 2 of Them Studied With Electroretinography , Acta Ophthal (Kobenhavn) 33:217-228, 1955.Crossref 15. Vaino-Mattila, B., and Zewi, M.: Quinine Amblyopia and the ERG , Acta Ophthal (Kobenhavn) 32:451-461, 1954.Crossref 16. Bishay, A.: Quinine Amhlyopia , Brit J Ophthal 30:281-287, 1946.Crossref 17. Braverman, B. L.; Korowsky, D. S.; and Kulvin, M. M.: Quinine Amaurosis , Amer J Ophthal 31:731-733, 1948. 18. Lincoff, M. H.: Quinine Amblyopia , AMA Arch Ophthal 53:382-384, 1955.Crossref 19. Turtz, C. A.: Transient Loss of Vision Following Use of Quinine , Amer J Ophthal 44:110-111, 1957.

Journal

Archives of Ophthalmology – American Medical Association

Published: Sep 1, 1964

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