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H. Scheie, B. Ashley, D. Burns (1963)
Treatment of Total Hyphema with FibrinolysinArchives of Ophthalmology, 69
S. Liebman, A. Pollen, S. Podos (1962)
Treatment of experimental total hyphema with intraocular fibrinolytic agents.Archives of ophthalmology, 68
Abstract In a prior publication,1 the authors, utilizing total hyphemas produced in rabbits, demonstrated the effects of streptokinase (Kinalysin) and fibrinolysin (Thrombolysin)* in the resolution of these clots, as compared with untreated and saline irrigated controls. Fibrinolysin is a combination of profibrinolysin (plasminogen) and an activator, streptokinase. Both enzyme preparations promoted resolution of fibrin and corneal edema. Red cell debris, however, was unaffected. Irrigation rather than injection of enzyme was necessary for any substantial benefit. These results have been confirmed by Scheie et al,2 who found that continuous 30 minute irrigation with fibrinolysin resulted in the clearing of human blood hyphemas in rabbit eyes. Simple injection was ineffectual. Saline irrigation resulted in poor clearing of clot. In addition, Scheie treated traumatic total hyphemas that were six hours to seven days old in human patients. Glaucoma was present. Results were favorable in all including reirrigation in one patient after he References 1. Both provided by Merck Sharp & Dohme. 2. Urokinase, provided by the Leo Pharmaceutical Co., Denmark. 3. Solu-Medrol (methylprednisilone) prepared for paranteral use by the Upjohn Co. 4. Liebman, S. D.; Pollen, A.; and Podos, S. M.: Treatment of Experimental Total Hyphema With Intraocular Fibrinolytic Agents , Arch Ophthal 68: 72, 1962.Crossref 5. Scheie, H. G.; Ashley, B. J.; and Burns, D. T.: Treatment of Total Hyphema With Fibrinolysin , Arch Ophthal 69:147, 1963.Crossref 6. Liebman, S.: Total Hyphema With Special Reference to Treatment of the Experimental Lesion, Trans Amer Ophthal Soc, to be published.
Archives of Ophthalmology – American Medical Association
Published: Apr 1, 1964
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