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Treatment of Experimental Total Hyphemas With Intraocular Fibrinolytic Agents: Part II

Treatment of Experimental Total Hyphemas With Intraocular Fibrinolytic Agents: Part II Abstract In a prior publication,1 the authors, utilizing total hyphemas produced in rabbits, demonstrated the effects of streptokinase (Kinalysin) and fibrinolysin (Thrombolysin)* in the resolution of these clots, as compared with untreated and saline irrigated controls. Fibrinolysin is a combination of profibrinolysin (plasminogen) and an activator, streptokinase. Both enzyme preparations promoted resolution of fibrin and corneal edema. Red cell debris, however, was unaffected. Irrigation rather than injection of enzyme was necessary for any substantial benefit. These results have been confirmed by Scheie et al,2 who found that continuous 30 minute irrigation with fibrinolysin resulted in the clearing of human blood hyphemas in rabbit eyes. Simple injection was ineffectual. Saline irrigation resulted in poor clearing of clot. In addition, Scheie treated traumatic total hyphemas that were six hours to seven days old in human patients. Glaucoma was present. Results were favorable in all including reirrigation in one patient after he References 1. Both provided by Merck Sharp & Dohme. 2. Urokinase, provided by the Leo Pharmaceutical Co., Denmark. 3. Solu-Medrol (methylprednisilone) prepared for paranteral use by the Upjohn Co. 4. Liebman, S. D.; Pollen, A.; and Podos, S. M.: Treatment of Experimental Total Hyphema With Intraocular Fibrinolytic Agents , Arch Ophthal 68: 72, 1962.Crossref 5. Scheie, H. G.; Ashley, B. J.; and Burns, D. T.: Treatment of Total Hyphema With Fibrinolysin , Arch Ophthal 69:147, 1963.Crossref 6. Liebman, S.: Total Hyphema With Special Reference to Treatment of the Experimental Lesion, Trans Amer Ophthal Soc, to be published. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Treatment of Experimental Total Hyphemas With Intraocular Fibrinolytic Agents: Part II

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References (2)

Publisher
American Medical Association
Copyright
Copyright © 1964 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1964.00970010553020
Publisher site
See Article on Publisher Site

Abstract

Abstract In a prior publication,1 the authors, utilizing total hyphemas produced in rabbits, demonstrated the effects of streptokinase (Kinalysin) and fibrinolysin (Thrombolysin)* in the resolution of these clots, as compared with untreated and saline irrigated controls. Fibrinolysin is a combination of profibrinolysin (plasminogen) and an activator, streptokinase. Both enzyme preparations promoted resolution of fibrin and corneal edema. Red cell debris, however, was unaffected. Irrigation rather than injection of enzyme was necessary for any substantial benefit. These results have been confirmed by Scheie et al,2 who found that continuous 30 minute irrigation with fibrinolysin resulted in the clearing of human blood hyphemas in rabbit eyes. Simple injection was ineffectual. Saline irrigation resulted in poor clearing of clot. In addition, Scheie treated traumatic total hyphemas that were six hours to seven days old in human patients. Glaucoma was present. Results were favorable in all including reirrigation in one patient after he References 1. Both provided by Merck Sharp & Dohme. 2. Urokinase, provided by the Leo Pharmaceutical Co., Denmark. 3. Solu-Medrol (methylprednisilone) prepared for paranteral use by the Upjohn Co. 4. Liebman, S. D.; Pollen, A.; and Podos, S. M.: Treatment of Experimental Total Hyphema With Intraocular Fibrinolytic Agents , Arch Ophthal 68: 72, 1962.Crossref 5. Scheie, H. G.; Ashley, B. J.; and Burns, D. T.: Treatment of Total Hyphema With Fibrinolysin , Arch Ophthal 69:147, 1963.Crossref 6. Liebman, S.: Total Hyphema With Special Reference to Treatment of the Experimental Lesion, Trans Amer Ophthal Soc, to be published.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Apr 1, 1964

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