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Steroid-Induced Elevation of Intraocular Pressure

Steroid-Induced Elevation of Intraocular Pressure Abstract Introduction It has been recently been suggested that long-term systemic steroids can produce a small elevation of intraocular pressure and a decrease in facility of outflow.1 The actual appearance of an overt glaucoma in patients on long-term systemic steroid therapy has previously been reported by Stern,2 Covell,3 and Harris.4 In all five of these patients the intraocular pressure remained elevated despite discontinuation of the steroids and required miotics, acetazolamide (Diamox), and even surgery, for satisfactory control. Therefore, one could not completely rule out the spontaneous appearance of angle-closure or open-angle glaucoma in these patients, unrelated to steroid therapy. François5 observed a 35-year-old man, with vernal catarrh, treated for over three years with topical steroids, who developed open-angle glaucoma in both eyes. One eye had a Bjerrum scotoma and required an iridencleisis. The intraocular pressure of the other eye returned to normal eight days after the References 1. Celestone Ophthalmic Drops (a solution containing 0.1% betamethasone alcohol and 10% sodium sulfacetamide) was kindly supplied by the Schering Drug Company. 2. Bernstein, H. N., and Schwartz, B.: Effects of Long-Term Systemic Steroids on Ocular Pressure and Tonographic Values , Arch Ophthal 68:742, 1962.Crossref 3. Stern, J. J.: Acute Glaucoma During Cortisone Therapy , Amer J Ophthal 36:389, 1953. 4. Covell, L. L.: Glaucoma Induced by Systemic Steroid Therapy , Amer J Ophthal 45:108, 1958. 5. Harris, J. L.: Glaucoma Associated With Steroid Therapy and Atopic Dermatitis , Amer J Ophthal 49:351, 1960. 6. François, J.: Glaucome apparemment simple, secondaire à la cortisonotherapie locale , Ophthalmologica (supp) 142:517, 1961. 7. Goldmann, H.: Cortisone Glaucoma , Arch Ophthal 68:621, 1962.Crossref 8. Asboe-Hansen, G.: Effect of the Adrenocorticotropic Hormone of the Pituitary on Mesenchymal Tissues , Scand J Clin Lab Invest 2:271, 1950.Crossref 9. Larsen, G.: The Viscosity of the Vitreous Humor Influenced by Hormones , Arch Ophthal 59:712, 1958.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Steroid-Induced Elevation of Intraocular Pressure

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References (9)

Publisher
American Medical Association
Copyright
Copyright © 1963 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1963.00960050017005
Publisher site
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Abstract

Abstract Introduction It has been recently been suggested that long-term systemic steroids can produce a small elevation of intraocular pressure and a decrease in facility of outflow.1 The actual appearance of an overt glaucoma in patients on long-term systemic steroid therapy has previously been reported by Stern,2 Covell,3 and Harris.4 In all five of these patients the intraocular pressure remained elevated despite discontinuation of the steroids and required miotics, acetazolamide (Diamox), and even surgery, for satisfactory control. Therefore, one could not completely rule out the spontaneous appearance of angle-closure or open-angle glaucoma in these patients, unrelated to steroid therapy. François5 observed a 35-year-old man, with vernal catarrh, treated for over three years with topical steroids, who developed open-angle glaucoma in both eyes. One eye had a Bjerrum scotoma and required an iridencleisis. The intraocular pressure of the other eye returned to normal eight days after the References 1. Celestone Ophthalmic Drops (a solution containing 0.1% betamethasone alcohol and 10% sodium sulfacetamide) was kindly supplied by the Schering Drug Company. 2. Bernstein, H. N., and Schwartz, B.: Effects of Long-Term Systemic Steroids on Ocular Pressure and Tonographic Values , Arch Ophthal 68:742, 1962.Crossref 3. Stern, J. J.: Acute Glaucoma During Cortisone Therapy , Amer J Ophthal 36:389, 1953. 4. Covell, L. L.: Glaucoma Induced by Systemic Steroid Therapy , Amer J Ophthal 45:108, 1958. 5. Harris, J. L.: Glaucoma Associated With Steroid Therapy and Atopic Dermatitis , Amer J Ophthal 49:351, 1960. 6. François, J.: Glaucome apparemment simple, secondaire à la cortisonotherapie locale , Ophthalmologica (supp) 142:517, 1961. 7. Goldmann, H.: Cortisone Glaucoma , Arch Ophthal 68:621, 1962.Crossref 8. Asboe-Hansen, G.: Effect of the Adrenocorticotropic Hormone of the Pituitary on Mesenchymal Tissues , Scand J Clin Lab Invest 2:271, 1950.Crossref 9. Larsen, G.: The Viscosity of the Vitreous Humor Influenced by Hormones , Arch Ophthal 59:712, 1958.Crossref

Journal

Archives of Ophthalmology – American Medical Association

Published: Jul 1, 1963

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