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Homoimmune Uveitis in the Guinea Pig: V. The Effect of Adrenal Corticosteroid

Homoimmune Uveitis in the Guinea Pig: V. The Effect of Adrenal Corticosteroid Abstract Introduction The beneficial effect of adrenocorticotropin and adrenal corticosteroids on human uveitis is well known.1,2 They also are effective in the treatment of sympathetic ophthalmia which is a possible autoimmune uveal inflammation.3 The severity of inflammation has been well controlled in exogenous experimental uveitis.4,5 Guinea pig homoimmune uveitis serves as an experimental model to evaluate the efficacy of adrenal corticosteroid therapy. Suppression of the inflammation in this type of uveitis may be due to either a nonspecific anti-inflammatory effect, or to a specific inhibition of the reaction caused by the antigen-antibody combination.In the earlier papers of this series the occurrence, clinical characteristics, and histopathologic characteristics of homoimmune uveitis have been discussed.6-8 The clinical observations of Part II and histopathologic observations of Part III serve as control observations for these experiments. Materials Pigmented Guinea Pig Uveal Antigen. —This was prepared by mixing uveal tracts with complete References 1. Supplied by Merck Sharp & Dohme, West Point, Pa., courtesy Dr. Elmer Alpert. 2. Steffensen, E. H.; Wishbow, A. J.; Nagle, F. O.; Smith, R. W., and Whitney, E. L.: Topical Cortisone in the Treatment of Anterior-Segment Eye Disease , Amer. J. Ophthal. 34:345-365, 1951. 3. Hogan, M. J.; Thygeson, P., and Kimura, S.: Uses and Abuses of Adrenal Steroids and Corticotropin , A.M.A. Arch. Ophthal. 53:165-176, 1955.Crossref 4. Vesterdal, E.: ACTH in the Treatment of Sympathetic Ophthalmia , Acta Ophthal. (Kbh.) 29:239, 1951.Crossref 5. Woods, A. C., and Wood, R. M.: The Action of ACTH and Cortisone on Experimental Ocular Inflammation , Bull. Johns Hopkins Hosp. 87:482-504, 1950. 6. Biegel, A. C.: Effect of Cortisone on Horse Serum Uveitis in Rabbits , A.M.A. Arch. Ophthal. 45:258-273, 1951.Crossref 7. Aronson, S. B.; Hogan, M. J., Zweigart, P.: Homoimmune Uveitis in the Guinea Pig: I. General Concepts of Auto- and Homoimmunity, Methods, and Manifestations , Arch. Ophthal. 69: 105-109, 1963.Crossref 8. Aronson, S. B.; Hogan, M. J., and Zweigart, P.: Homoimmune Uveitis in the Guinea Pig: II. Clinical Manifestations , Arch. Ophthal. 69:203, 1963.Crossref 9. Aronson, S. B.; Hogan, M. J., and Zweigart, P.: Homoimmune Uveitis in the Guinea Pig: III. Histopathologic Manifestations of the Disease , Arch. Ophthal. 69:208, 1963.Crossref 10. Dougherty, T. F., and White, A.: Functional Alterations in Lymphoid Tissue Induced by Adrenal Cortical Secretion , Amer. J. Anat. 77:81, 1945.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Homoimmune Uveitis in the Guinea Pig: V. The Effect of Adrenal Corticosteroid

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References (10)

Publisher
American Medical Association
Copyright
Copyright © 1963 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1963.00960040385021
Publisher site
See Article on Publisher Site

Abstract

Abstract Introduction The beneficial effect of adrenocorticotropin and adrenal corticosteroids on human uveitis is well known.1,2 They also are effective in the treatment of sympathetic ophthalmia which is a possible autoimmune uveal inflammation.3 The severity of inflammation has been well controlled in exogenous experimental uveitis.4,5 Guinea pig homoimmune uveitis serves as an experimental model to evaluate the efficacy of adrenal corticosteroid therapy. Suppression of the inflammation in this type of uveitis may be due to either a nonspecific anti-inflammatory effect, or to a specific inhibition of the reaction caused by the antigen-antibody combination.In the earlier papers of this series the occurrence, clinical characteristics, and histopathologic characteristics of homoimmune uveitis have been discussed.6-8 The clinical observations of Part II and histopathologic observations of Part III serve as control observations for these experiments. Materials Pigmented Guinea Pig Uveal Antigen. —This was prepared by mixing uveal tracts with complete References 1. Supplied by Merck Sharp & Dohme, West Point, Pa., courtesy Dr. Elmer Alpert. 2. Steffensen, E. H.; Wishbow, A. J.; Nagle, F. O.; Smith, R. W., and Whitney, E. L.: Topical Cortisone in the Treatment of Anterior-Segment Eye Disease , Amer. J. Ophthal. 34:345-365, 1951. 3. Hogan, M. J.; Thygeson, P., and Kimura, S.: Uses and Abuses of Adrenal Steroids and Corticotropin , A.M.A. Arch. Ophthal. 53:165-176, 1955.Crossref 4. Vesterdal, E.: ACTH in the Treatment of Sympathetic Ophthalmia , Acta Ophthal. (Kbh.) 29:239, 1951.Crossref 5. Woods, A. C., and Wood, R. M.: The Action of ACTH and Cortisone on Experimental Ocular Inflammation , Bull. Johns Hopkins Hosp. 87:482-504, 1950. 6. Biegel, A. C.: Effect of Cortisone on Horse Serum Uveitis in Rabbits , A.M.A. Arch. Ophthal. 45:258-273, 1951.Crossref 7. Aronson, S. B.; Hogan, M. J., Zweigart, P.: Homoimmune Uveitis in the Guinea Pig: I. General Concepts of Auto- and Homoimmunity, Methods, and Manifestations , Arch. Ophthal. 69: 105-109, 1963.Crossref 8. Aronson, S. B.; Hogan, M. J., and Zweigart, P.: Homoimmune Uveitis in the Guinea Pig: II. Clinical Manifestations , Arch. Ophthal. 69:203, 1963.Crossref 9. Aronson, S. B.; Hogan, M. J., and Zweigart, P.: Homoimmune Uveitis in the Guinea Pig: III. Histopathologic Manifestations of the Disease , Arch. Ophthal. 69:208, 1963.Crossref 10. Dougherty, T. F., and White, A.: Functional Alterations in Lymphoid Tissue Induced by Adrenal Cortical Secretion , Amer. J. Anat. 77:81, 1945.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Mar 1, 1963

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