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Clinical Evaluation of the Precipitin Test in the Postoperative Course of Keratoplasty

Clinical Evaluation of the Precipitin Test in the Postoperative Course of Keratoplasty Abstract In 1914, Friedberg1 observed a virulent inflammation in the host tissue surrounding an implant 14 days postoperatively and inferred from this observation that the serological relationship played a role in graft healing. The inflammation, which was rapidly reduced, was tentatively interpreted as an anaphylactic reaction. Following this report, and especially recently, many authors, such as Müller and Maumenee,2-4 Choyce5 Babel and Bourquin,6 Maumenee,7 Morawiecki,8 Basu and Ormsby,9,10 Kornblueth,11 Lieb and Lerman,12 Kamata,13 and Arai,14,15 have recognized an antigen-antibody reaction after homo- and heterocorneal grafting. Postoperative graft opacity—the most unhappy complication of keratoplasty for the surgeon as well as the patient—may have a variety of causes. In 1948, Paufique, Sourdille, and Offretin16 applied the term "maladie du greffon" to the opacity that arose inexplicably without manifest operative complications. Local allergy was regarded as one of the most important causal factors, References 1. 4-butyl-1, 2-dipheny1-3, 5-pyrazolidinedione. 2. Friedberg, T.: Ein Fall von Hornhauttransplantation mit ungewöhnlichem Verlauf, vielleicht infolge von Anaphylaxiereaktion , Klin. Monatsbl. Augenh. 52:436, 1914. 3. Müller, H., and Maumenee, A. E.: Considerations sur la maladie du greffon , Arch. d'opht. 11:146, 1951. 4. Müller, H., and Maumenee, A. E.: Ein Trübung klarer Hornhauttransplantate durch individual-spezifische Sensibilisierung des Empfangers , Arch. f. Ophth. 152:1, 1951. 5. Müller, H., and Maumenee, A. E.: Tierexperimentelle Transplantation von Sklera in die Hornhaut , Arch. f. Ophth. 152:521, 1952. 6. Choyce, D. P.: Successful Transplantation of Human and Cat Corneal Tissue into Rabbit Cornea , Brit. J. Ophth. 36:537, 1952.Crossref 7. Babel, J., and Bourquin, J. B.: Experimental Research with Corneal Heterografts , Brit, J. Ophth. 36:529, 1952.Crossref 8. Maumenee, A. E.: The Immune Concept: Its Relation to Corneal Homotransplantation , Ann. New York Acad. Sc. 59:453, 1955.Crossref 9. Morawiecki, J.: Certain Problems of Immunology and Pathology of the Cornea in the Light of New Experimental Data, Ref. XXV. Zjazdu Okul. Pols. 300, 1956. 10. Basu, P. K., and Ormsby, H. L.: Studies of Immunity with Interlamellar Corneal Homograft in Rabbit , Am. Ophth. 44:598, 1957. 11. Basu, P. K., and Ormsby, H. L.: Corneal Heterograft in Rabbits , Am. J. Ophth. 44:477, 1957. 12. Kornblueth, W., and Nelken, E.: A Study on Donor-Recipient Sensitization in Experimental Homologous Partial Lamellar Corneal Graft , Am. J. Ophth. 45:843, 1958. 13. Lieb, W. A., and Lerman, S.: Keratoplasty and Allergic Reactions , Klin. Monatsbl. Augenh. 132:31, 1958. 14. Kamata, W.: An Experimental Study of Heterokeratoplasty , Acta Soc. ophth. japon. 61:1098, 1957. 15. Arai, T.: Serological Studies on Heterocorneal Graft , Acta Soc. ophth. japon. 62:2266, 1958. 16. Arai, T.: Serological Studies on Corneal Heterograft II , Acta Soc. ophth. japon. 63:1582, 1959. 17. Paufique, L.; Sourdille, G. P., and Offretin, G.: Les greffes de la cornée , Paris, Masson & Cie, 1948 18. Paton, R. T.: Keratoplasty , New York, McGraw-Hill Book Company, Inc., 1955, p. 213. 19. Barraquer, J. I., Jr.: International Symposium on Corneal Survey: Technique of Penetrating Keratoplasty , Am. J. Ophth. 33:6 (March, (Pt. 2) ) 1950. 20. Tsutsui, J.: Clinical Evaluation of Precipitin Test in the Postoperative Course of Keratoplasty (Preliminary) , Acta Soc. ophth. japon. 63:950, 1959. 21. Ascher, K. W.: Zur Keratoplastikfrage: II. Bericht über die bis zum Ende des Sommersemesters 1921 ausgeführten Hornhautüberpflanzungen , Arch. f. Ophth. 107:439, 1922. 22. Nelken, E.; Michaelson, I. C.; Nelken, D., and Gurevitch, J.: Immunologic Properties of the Human Cornea and the Aqueous Humor and their Relationship to Corneal Grafting , Acta med. orient. 15:281, 1956. 23. Mehri, P.; Becker, B., and Oglesby, R.: Corneal Transplant and Blood Types: A Clinical Study , Am. J. Ophth. 47:48, 1959. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Clinical Evaluation of the Precipitin Test in the Postoperative Course of Keratoplasty

Archives of Ophthalmology , Volume 65 (3) – Mar 1, 1961

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References (21)

Publisher
American Medical Association
Copyright
Copyright © 1961 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1961.01840020377010
Publisher site
See Article on Publisher Site

Abstract

Abstract In 1914, Friedberg1 observed a virulent inflammation in the host tissue surrounding an implant 14 days postoperatively and inferred from this observation that the serological relationship played a role in graft healing. The inflammation, which was rapidly reduced, was tentatively interpreted as an anaphylactic reaction. Following this report, and especially recently, many authors, such as Müller and Maumenee,2-4 Choyce5 Babel and Bourquin,6 Maumenee,7 Morawiecki,8 Basu and Ormsby,9,10 Kornblueth,11 Lieb and Lerman,12 Kamata,13 and Arai,14,15 have recognized an antigen-antibody reaction after homo- and heterocorneal grafting. Postoperative graft opacity—the most unhappy complication of keratoplasty for the surgeon as well as the patient—may have a variety of causes. In 1948, Paufique, Sourdille, and Offretin16 applied the term "maladie du greffon" to the opacity that arose inexplicably without manifest operative complications. Local allergy was regarded as one of the most important causal factors, References 1. 4-butyl-1, 2-dipheny1-3, 5-pyrazolidinedione. 2. Friedberg, T.: Ein Fall von Hornhauttransplantation mit ungewöhnlichem Verlauf, vielleicht infolge von Anaphylaxiereaktion , Klin. Monatsbl. Augenh. 52:436, 1914. 3. Müller, H., and Maumenee, A. E.: Considerations sur la maladie du greffon , Arch. d'opht. 11:146, 1951. 4. Müller, H., and Maumenee, A. E.: Ein Trübung klarer Hornhauttransplantate durch individual-spezifische Sensibilisierung des Empfangers , Arch. f. Ophth. 152:1, 1951. 5. Müller, H., and Maumenee, A. E.: Tierexperimentelle Transplantation von Sklera in die Hornhaut , Arch. f. Ophth. 152:521, 1952. 6. Choyce, D. P.: Successful Transplantation of Human and Cat Corneal Tissue into Rabbit Cornea , Brit. J. Ophth. 36:537, 1952.Crossref 7. Babel, J., and Bourquin, J. B.: Experimental Research with Corneal Heterografts , Brit, J. Ophth. 36:529, 1952.Crossref 8. Maumenee, A. E.: The Immune Concept: Its Relation to Corneal Homotransplantation , Ann. New York Acad. Sc. 59:453, 1955.Crossref 9. Morawiecki, J.: Certain Problems of Immunology and Pathology of the Cornea in the Light of New Experimental Data, Ref. XXV. Zjazdu Okul. Pols. 300, 1956. 10. Basu, P. K., and Ormsby, H. L.: Studies of Immunity with Interlamellar Corneal Homograft in Rabbit , Am. Ophth. 44:598, 1957. 11. Basu, P. K., and Ormsby, H. L.: Corneal Heterograft in Rabbits , Am. J. Ophth. 44:477, 1957. 12. Kornblueth, W., and Nelken, E.: A Study on Donor-Recipient Sensitization in Experimental Homologous Partial Lamellar Corneal Graft , Am. J. Ophth. 45:843, 1958. 13. Lieb, W. A., and Lerman, S.: Keratoplasty and Allergic Reactions , Klin. Monatsbl. Augenh. 132:31, 1958. 14. Kamata, W.: An Experimental Study of Heterokeratoplasty , Acta Soc. ophth. japon. 61:1098, 1957. 15. Arai, T.: Serological Studies on Heterocorneal Graft , Acta Soc. ophth. japon. 62:2266, 1958. 16. Arai, T.: Serological Studies on Corneal Heterograft II , Acta Soc. ophth. japon. 63:1582, 1959. 17. Paufique, L.; Sourdille, G. P., and Offretin, G.: Les greffes de la cornée , Paris, Masson & Cie, 1948 18. Paton, R. T.: Keratoplasty , New York, McGraw-Hill Book Company, Inc., 1955, p. 213. 19. Barraquer, J. I., Jr.: International Symposium on Corneal Survey: Technique of Penetrating Keratoplasty , Am. J. Ophth. 33:6 (March, (Pt. 2) ) 1950. 20. Tsutsui, J.: Clinical Evaluation of Precipitin Test in the Postoperative Course of Keratoplasty (Preliminary) , Acta Soc. ophth. japon. 63:950, 1959. 21. Ascher, K. W.: Zur Keratoplastikfrage: II. Bericht über die bis zum Ende des Sommersemesters 1921 ausgeführten Hornhautüberpflanzungen , Arch. f. Ophth. 107:439, 1922. 22. Nelken, E.; Michaelson, I. C.; Nelken, D., and Gurevitch, J.: Immunologic Properties of the Human Cornea and the Aqueous Humor and their Relationship to Corneal Grafting , Acta med. orient. 15:281, 1956. 23. Mehri, P.; Becker, B., and Oglesby, R.: Corneal Transplant and Blood Types: A Clinical Study , Am. J. Ophth. 47:48, 1959.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Mar 1, 1961

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