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Pathogenetic Factors in Experimental Galactose Cataract: Part IV

Pathogenetic Factors in Experimental Galactose Cataract: Part IV Abstract Previous communications have reported on certain biochemical changes that occur in the lenses of young rats (aged 28-32 days) maintained on a cataractogenic galactose diet.1-3 The accumulation of galactose-1-phosphate in these lenses apparently acts as or gives rise to an inhibitor of the enzyme glucose-6-phosphate dehydrogenase (G-6-P-D) during the first few days that these animals are maintained on a high galactose diet.1 The hexose monophosphate shunt is concurrently impaired as evidenced by a marked fall in the C1/C6 ratio of C14O2 recovered from these lenses incubated with glucose labeled in the number 1 or number 6 carbon atom.2 The concentration of high energy phosphate (ATP) in these lenses also decreases after the animals have been maintained on the diet for 3 days. In order to further elucidate some of these changes that occur within the lens under the cataractogenic influence of References 1. Lerman, S.: A.M.A. Arch. Ophth. 63:128, 1960.Crossref 2. Lerman, S.: A.M.A. Arch. Ophth. 63:132, 1960.Crossref 3. Lerman, S., and Ishida, B. K.: A.M.A. Arch. Ophth. 63:136, 1960.Crossref 4. Lerman, S.: Science 133:100, 1961.Crossref 5. Yodkin, A. M., and Arnold, C. H.: Arch. Ophth. 14:960, 1936.Crossref 6. Bassham, J. A.; Birt, L. M.; Hems, R., and Loenig, U. E.: Biochem. J. 73:491, 1959. 7. Kaplan, N. O.; Colowick, S. P., and Neufeld, E. F.: J. Biol. Chem. 205:1, 1953. 8. Stein, A. M.; Kaplan, N. O., and Ciotti, M. M.: J. Biol. Chem. 234:979, 1959. 9. Wortman, B., and Schneider, A.: Biochem. & Biophys. Res. Comm. 2:179, 1960. 10. Pirie, A.; van Heyningen, R., and Boag, J. W.: Biochem. J. 54:682, 1953. 11. Roe, J. H., in Methods of Biochemical Analysis , Vol. 1, edited by David Glick, New York, Interscience Publishers, Inc., 1954, p. 120. 12. Dische, Z.; Zelmenis, G., and Youlos, J.: Am. J. Ophth. 44:332, 1957. 13. Lerman, S.: Unpublished data. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Pathogenetic Factors in Experimental Galactose Cataract: Part IV

Archives of Ophthalmology , Volume 65 (3) – Mar 1, 1961

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References (21)

Publisher
American Medical Association
Copyright
Copyright © 1961 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1961.01840020336004
Publisher site
See Article on Publisher Site

Abstract

Abstract Previous communications have reported on certain biochemical changes that occur in the lenses of young rats (aged 28-32 days) maintained on a cataractogenic galactose diet.1-3 The accumulation of galactose-1-phosphate in these lenses apparently acts as or gives rise to an inhibitor of the enzyme glucose-6-phosphate dehydrogenase (G-6-P-D) during the first few days that these animals are maintained on a high galactose diet.1 The hexose monophosphate shunt is concurrently impaired as evidenced by a marked fall in the C1/C6 ratio of C14O2 recovered from these lenses incubated with glucose labeled in the number 1 or number 6 carbon atom.2 The concentration of high energy phosphate (ATP) in these lenses also decreases after the animals have been maintained on the diet for 3 days. In order to further elucidate some of these changes that occur within the lens under the cataractogenic influence of References 1. Lerman, S.: A.M.A. Arch. Ophth. 63:128, 1960.Crossref 2. Lerman, S.: A.M.A. Arch. Ophth. 63:132, 1960.Crossref 3. Lerman, S., and Ishida, B. K.: A.M.A. Arch. Ophth. 63:136, 1960.Crossref 4. Lerman, S.: Science 133:100, 1961.Crossref 5. Yodkin, A. M., and Arnold, C. H.: Arch. Ophth. 14:960, 1936.Crossref 6. Bassham, J. A.; Birt, L. M.; Hems, R., and Loenig, U. E.: Biochem. J. 73:491, 1959. 7. Kaplan, N. O.; Colowick, S. P., and Neufeld, E. F.: J. Biol. Chem. 205:1, 1953. 8. Stein, A. M.; Kaplan, N. O., and Ciotti, M. M.: J. Biol. Chem. 234:979, 1959. 9. Wortman, B., and Schneider, A.: Biochem. & Biophys. Res. Comm. 2:179, 1960. 10. Pirie, A.; van Heyningen, R., and Boag, J. W.: Biochem. J. 54:682, 1953. 11. Roe, J. H., in Methods of Biochemical Analysis , Vol. 1, edited by David Glick, New York, Interscience Publishers, Inc., 1954, p. 120. 12. Dische, Z.; Zelmenis, G., and Youlos, J.: Am. J. Ophth. 44:332, 1957. 13. Lerman, S.: Unpublished data.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Mar 1, 1961

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