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Centrocecal Scotomas Due to Chlorpropamide

Centrocecal Scotomas Due to Chlorpropamide Abstract The following case report is submitted because no similar case could be found in the literature. It is conceivable that given a patient with diabetic retinopathy one might attribute the loss of vision to the retinal pathology—whereas an additional cause such as toxic amblyopia from medication might be at fault. Chlorpropamide (Diabenese*) is an arylsulfonylurea. It is 1-propyl-3-(p-chlorobenzenesulfonyl) urea, with a molecular weight of 276.76 and an empirical formula of C10H13CIN2O3S. It is a sulfonamide, It is rapidly absorbed from the gastrointestinal tract of man. The side-effects of chlorpropamide include severe hypoglycemia and jaundice. The latter is associated with a skin rash and occurs within 2 to 5 weeks of the initiation of therapy. It is characterized by an elevation of the serum alkaline phosphatase. Leukopenia, eosinophilia, lymphocytosis, and decrease in blood platelets may occur. Chlorpropamide has produced bizarre neurologic References 1. Chas. Pfizer & Co., Inc. 2. A vitamin preparation containing vitamin B1, vitamin B2, pantothenic acid, vitamin B6, niacin, with yeast and liver (American Pharmaceutical). 3. Dolger, H.: An Assessment of Oral Antidiabetic Therapy , J. Mount Sinai Hosp. N.Y. 27: 33 ( (Jan.-Feb.) ), 1960. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Centrocecal Scotomas Due to Chlorpropamide

GIVNER, ISADORE
Archives of Ophthalmology , Volume 66 (1) – Jul 1, 1961
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Centrocecal Scotomas Due to Chlorpropamide

Abstract

Abstract The following case report is submitted because no similar case could be found in the literature. It is conceivable that given a patient with diabetic retinopathy one might attribute the loss of vision to the retinal pathology—whereas an additional cause such as toxic amblyopia from medication might be at fault. Chlorpropamide (Diabenese*) is an arylsulfonylurea. It is 1-propyl-3-(p-chlorobenzenesulfonyl) urea, with a molecular weight of 276.76 and an empirical formula of...
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References (2)

Publisher
American Medical Association
Copyright
Copyright © 1961 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1961.00960010066013
Publisher site
See Article on Publisher Site

Abstract

Abstract The following case report is submitted because no similar case could be found in the literature. It is conceivable that given a patient with diabetic retinopathy one might attribute the loss of vision to the retinal pathology—whereas an additional cause such as toxic amblyopia from medication might be at fault. Chlorpropamide (Diabenese*) is an arylsulfonylurea. It is 1-propyl-3-(p-chlorobenzenesulfonyl) urea, with a molecular weight of 276.76 and an empirical formula of C10H13CIN2O3S. It is a sulfonamide, It is rapidly absorbed from the gastrointestinal tract of man. The side-effects of chlorpropamide include severe hypoglycemia and jaundice. The latter is associated with a skin rash and occurs within 2 to 5 weeks of the initiation of therapy. It is characterized by an elevation of the serum alkaline phosphatase. Leukopenia, eosinophilia, lymphocytosis, and decrease in blood platelets may occur. Chlorpropamide has produced bizarre neurologic References 1. Chas. Pfizer & Co., Inc. 2. A vitamin preparation containing vitamin B1, vitamin B2, pantothenic acid, vitamin B6, niacin, with yeast and liver (American Pharmaceutical). 3. Dolger, H.: An Assessment of Oral Antidiabetic Therapy , J. Mount Sinai Hosp. N.Y. 27: 33 ( (Jan.-Feb.) ), 1960.

Journal

Archives of Ophthalmology – American Medical Association

Published: Jul 1, 1961

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