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W. L. Miechowski (1956)
Studies on Proteolytic Enzymes: II. Trypsin and Chymotrypsin in Relation to Inflammatory ProcessesJ. Pharmacol. Exp. Ther., 116
B. H. Jenkins (1956)
Use of Intramuscular Chymotrypsin in Ocular ConditionsJ. Med. A. Georgia, 45
H. Brugger (1935)
Über Herpes corneae
Jenkins Bh (1959)
Chymotrypsin. Its varied uses in eye, ear, nose, throat, and related conditions.Medical times, 87
J. Connell, L. Rousselot (1951)
The use of enzymatic agents in the debridement of burn and wound sloughs.Surgery, 30 1
H. Tagnon, A. Weinglass, W. Goodpastor (1945)
THE NATURE AND MECHANISM OF SHOCK PRODUCED BY THE INTRAVENOUS INJECTION OF CHYMOTRYPSINAmerican Journal of Physiology, 143
S. Sherry, A. Titchener, L. Gottesman, P. Wasserman, W. Troll (1954)
The enzymatic dissolution of experimental arterial thrombi in the dog by trypsin, chymotrypsin and plasminogen activators.The Journal of clinical investigation, 33 10
Abstract Every ophthalmologist is familiar with the typical clinical appearance of dendritic ulcer of the cornea. Since the first description of this virus infection of the cornea as a clinical entity by Horner1 in 1871, many forms of treatment have been tried. Among the therapeutic agents reported are alcohol, potassium iodide, hydrogen peroxide, silver nitrate, trichloracetic acid, epinephrine hydrochloride under a contact glass, alkalis, vaccination, curettage, paracentesis of the anterior chamber, ultraviolet light, x-rays, cobalt, strontium90, strong solution of iodine, and U.S.P. ether. Of all of the agents mentioned ether and strong solution of iodine have proved to be the most effective. However, both of these agents result in severe discomfort for the patient and they increase rather than decrease the possibility of corneal scarring. The therapeutic application of chymotrypsin became possible after its crystallization in 1933. It is a proteolytic enzyme extracted from mammalian pancreas and is now References 1. Horner, J. F.: Über Herpes Corneae , Klin. Mbl. Augenheilk. 9:321, 1871. 2. Miechowski, W. L., and Ercoli, N. J.: Studies on Proteolytic Enzymes: II. Trypsin and Chymotrypsin in Relation to Inflammatory Processes , J. Pharmacol. Exp. Ther. 116:43, 1956. 3. Sherry, S., et al.: The Enzymatic Dissolution of Experimental Arterial Thrombi in the Dog by Trypsin, Chymotrypsin and Plasminogen Activated , J. Clin. Invest. 33:1303, 1954.Crossref 4. Tagnon, H. J., et al.: Nature and Mechanism of Shock Produced by Intravenous Injection of Chymotrypsin , Amer. J. Physiol. 143:644, 1945. 5. Connell, J. E., and Rousselat, L. M.: The Use of Enzymatic Agents in the Débridement of Burn and Wound Sloughs , Surgery 30:43, 1951. 6. Jenkins, B. H.: Chymotrypsin, Its Varied Uses in Eye, Ear, Nose, Throat, and Related Conditions , Med. Times 87:1613, 1959. 7. Jenkins, B. H.: Use of Intramuscular Chymotrypsin in Ocular Conditions , J. Med. A. Georgia 45:431, 1956.
Archives of Ophthalmology – American Medical Association
Published: Jul 1, 1961
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