Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Latex Agglutination Test in Uveitis

Latex Agglutination Test in Uveitis Abstract In 1922, Meyer1 reported that the serums of certain patients with rheumatoid arthritis agglutinated sensitized sheep erythrocytes. In 1931, Cecil, Nicholls, and Stainsby2 observed the agglutination of β-hemolytic streptococci by the serum of certain patients suffering from rheumatoid arthritis. The suspected etiologic relationship between streptococcal infections and rheumatoid arthritis indicated that the erythrocytes agglutinated because of a precipitin reaction which takes place on the surface of each erythrocyte.3 Because of the variability of preserved sheep erythrocytes Singer and Plotz substituted biologically inert uniform size polystyrene latex particles. With added γ-globulin and mixed with progressive dilutions of the serum to be tested they devised the latex fixation test for rheumatoid arthritis.3 With this technique they found 71.3% positive reactions in serums from patients afflicted by rheumatoid arthritis. The association of uveitis with rheumatoid arthritis is well documented. Stanworth and Sharp4 found evidence of rheumatoid arthritis in References 1. Meyer, K.: Über Hamagglutininvermehrung und Hamagglutinationfordernde Wirkung bei menschlichen Seren , Ztschr. f. Immunitätsforsch. u. exper. Therap. 34:229, 1922. 2. Cecil, R. L.; Nicholls, E. E., and Stainsby, W. J.: Etiology of Rheumatoid Arthritis , Am. J.M. Sc. 181:12-25 ( (Jan.) ) 1931.Crossref 3. Singer, J. M., and Plotz, C. M.: The Latex Fixation Test: 1. Application to the Serologic Diagnosis of Rheumatoid Arthritis , Am. J. Med. 21:888-892 ( (Dec.) ) 1956.Crossref 4. Stanworth, A., and Sharp, J.: Uveitis and Rheumatic Diseases , Ann. Rheumat. Dis. 15:140-150 ( (June) ) 1956.Crossref 5. Hallett, J. W.; Wolkowicz, M. I.; Feria, Q. A.; Leopold, I. H., and Wijewski, E.: Streptococcal Serology in Uveitis , A.M.A. Arch. Ophth. 61:79-83 ( (Jan.) ) 1959.Crossref 6. Becker, B., in Comment on Uveitis and Rheumatic Diseases , Survey Ophth. 2:71 ( (Feb.) ) 1957. 7. Woods, A. C.: Use of Specific Streptococcus Vaccine in Nongranulomatous Uveitis , A.M.A. Arch. Ophth. 50:129-146 ( (Aug.) ) 1953.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Latex Agglutination Test in Uveitis

Download PDF
2 pages

Loading next page...
 
/lp/american-medical-association/latex-agglutination-test-in-uveitis-harKUOepuL

References (7)

Publisher
American Medical Association
Copyright
Copyright © 1960 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1960.01840010135014
Publisher site
See Article on Publisher Site

Abstract

Abstract In 1922, Meyer1 reported that the serums of certain patients with rheumatoid arthritis agglutinated sensitized sheep erythrocytes. In 1931, Cecil, Nicholls, and Stainsby2 observed the agglutination of β-hemolytic streptococci by the serum of certain patients suffering from rheumatoid arthritis. The suspected etiologic relationship between streptococcal infections and rheumatoid arthritis indicated that the erythrocytes agglutinated because of a precipitin reaction which takes place on the surface of each erythrocyte.3 Because of the variability of preserved sheep erythrocytes Singer and Plotz substituted biologically inert uniform size polystyrene latex particles. With added γ-globulin and mixed with progressive dilutions of the serum to be tested they devised the latex fixation test for rheumatoid arthritis.3 With this technique they found 71.3% positive reactions in serums from patients afflicted by rheumatoid arthritis. The association of uveitis with rheumatoid arthritis is well documented. Stanworth and Sharp4 found evidence of rheumatoid arthritis in References 1. Meyer, K.: Über Hamagglutininvermehrung und Hamagglutinationfordernde Wirkung bei menschlichen Seren , Ztschr. f. Immunitätsforsch. u. exper. Therap. 34:229, 1922. 2. Cecil, R. L.; Nicholls, E. E., and Stainsby, W. J.: Etiology of Rheumatoid Arthritis , Am. J.M. Sc. 181:12-25 ( (Jan.) ) 1931.Crossref 3. Singer, J. M., and Plotz, C. M.: The Latex Fixation Test: 1. Application to the Serologic Diagnosis of Rheumatoid Arthritis , Am. J. Med. 21:888-892 ( (Dec.) ) 1956.Crossref 4. Stanworth, A., and Sharp, J.: Uveitis and Rheumatic Diseases , Ann. Rheumat. Dis. 15:140-150 ( (June) ) 1956.Crossref 5. Hallett, J. W.; Wolkowicz, M. I.; Feria, Q. A.; Leopold, I. H., and Wijewski, E.: Streptococcal Serology in Uveitis , A.M.A. Arch. Ophth. 61:79-83 ( (Jan.) ) 1959.Crossref 6. Becker, B., in Comment on Uveitis and Rheumatic Diseases , Survey Ophth. 2:71 ( (Feb.) ) 1957. 7. Woods, A. C.: Use of Specific Streptococcus Vaccine in Nongranulomatous Uveitis , A.M.A. Arch. Ophth. 50:129-146 ( (Aug.) ) 1953.Crossref

Journal

Archives of Ophthalmology – American Medical Association

Published: Jul 1, 1960

There are no references for this article.