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Ocular Findings in Cystic Fibrosis of the Pancreas: A Preliminary Report

Ocular Findings in Cystic Fibrosis of the Pancreas: A Preliminary Report Abstract Cystic fibrosis of the pancreas is a hereditary disease of children and young adults characterized by dysfunction of many of the exocrine glands. It is manifest most often by pancreatic insufficiency, chronic lung disease, and excessive loss of sodium and chloride in sweat. The etiology is unknown and although the majority of patients die in infancy or childhood of chronic lung disease, an increasing number are living in the second and third decades. Cystic fibrosis is a relatively new disease, having been clearly delineated in this country for the first time by Andersen in 1938.1 Since that time, the disorder has attracted much attention and is being intensively studied in many centers throughout the world.2,3,4 The frequency of the recessive genetic expression of this disease has been estimated as of the order of 1:1,000 live births. The diagnosis can be made relatively easily by eliciting a characteristic history References 1. Andersen, D. H.: Cystic Fibrosis of the Pancreas and Its Relation to Celiac Disease: A Clinical and Pathologic Study , Am. J. Dis. Child. 56:344-399, 1938.Crossref 2. Andersen, D. H.: Cystic Fibrosis of the Pancreas , J. Chron. Dis. 7:58-90, 1958.Crossref 3. Bodian, M.: Fibrocystic Disease of the Pancreas: A Congenital Disorder of Mucus Production-Mucosis , London, William Heinemann Medical Books, Ltd., 1952. 4. Shwachman, H.; Leubner, H., and Catzel, P.: Mucoviscidosis , in Advances in Pediatrics , edited by S. Z. Levine, Chicago, The Year Book Publishers, Inc., 1955, pp. 249-323. 5. Neuhauser, E. B. D.: Roentgen Changes Associated with Pancreatic Insufficiency in Early Life , Radiology 46:319-328, 1946.Crossref 6. di Sant'Agnese, P. A.: Fibrocystic Disease of the Pancreas with Normal or Partial Pancreatic Function: Current Views on Pathogenesis and Diagnosis , Pediatrics 15:683-697, 1955. 7. Shwachman, H., and Kulczycki, L.: Long-Term Study of One Hundred Five Patients with Cystic Fibrosis , A.M.A.J. Dis. Child. 96:6-15, 1958.Crossref 8. Wu, H.: A New Colorimetric Method for the Determination of Plasma Proteins , J. Biol. Chem. 51:33-39, 1922. 9. Shapiro, S., and Weiner, M.: Coagulation, Thrombosis, and Dicumarol , New York, Brooklyn Medical Press, 1949, p. 106. 10. Sia, R. H. P., and Wu, H.: Serum Globulin in Kala-Azar , China M.J. 35:527-532, 1921. 11. Sia, R. H. P.: A Simple Method for Estimating Quantitative Differences in the Globulin Precipitation Test in Kala-Azar , China M.J. 38:35-42, 1924. 12. Kabat, E. A.; Moore, D. H., and Landow, H.: An Electrophoretic Study of the Protein Components in Cerebrospinal Fluid and their Relationship to the Serum Proteins , J. Clin. Invest. 21:571-577, 1942.Crossref 13. Katzenelbogen, S.: The Cerebrospinal Fluid and Its Relation to the Blood: A Physiological and Clinical Study , Baltimore, Johns Hopkins Press, 1935. 14. Yahr, M. D.; Goldensohn, S. S., and Kabat, E. A.: Further Studies on the Gamma Globulin Content of Cerebrospinal Fluid in Multiple Sclerosis and Other Neurological Diseases , Annals of N.Y. Acad. Sc. 58:613-624, 1954.Crossref 15. Austen, F. K.; Carmichael, M. W., and Adams, R. D.: Neurologic Manifestations of Chronic Pulmonary Insufficiency , New England J. Med. 257:579-590, 1957.Crossref 16. Bass, M. H.: The Relation of Vitamin A Intake to Cerebrospinal Fluid Pressure: A Review , J. Mt. Sinai Hosp., New York 24:713-719, 1957. 17. Waldenström, J.: Macroglobulinemia, Triangle ; The Sandoz J.M. Sc. 3:262-270, 1958. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Ophthalmology American Medical Association

Ocular Findings in Cystic Fibrosis of the Pancreas: A Preliminary Report

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References (20)

Publisher
American Medical Association
Copyright
Copyright © 1960 American Medical Association. All Rights Reserved.
ISSN
0096-6339
DOI
10.1001/archopht.1960.00950020393001
Publisher site
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Abstract

Abstract Cystic fibrosis of the pancreas is a hereditary disease of children and young adults characterized by dysfunction of many of the exocrine glands. It is manifest most often by pancreatic insufficiency, chronic lung disease, and excessive loss of sodium and chloride in sweat. The etiology is unknown and although the majority of patients die in infancy or childhood of chronic lung disease, an increasing number are living in the second and third decades. Cystic fibrosis is a relatively new disease, having been clearly delineated in this country for the first time by Andersen in 1938.1 Since that time, the disorder has attracted much attention and is being intensively studied in many centers throughout the world.2,3,4 The frequency of the recessive genetic expression of this disease has been estimated as of the order of 1:1,000 live births. The diagnosis can be made relatively easily by eliciting a characteristic history References 1. Andersen, D. H.: Cystic Fibrosis of the Pancreas and Its Relation to Celiac Disease: A Clinical and Pathologic Study , Am. J. Dis. Child. 56:344-399, 1938.Crossref 2. Andersen, D. H.: Cystic Fibrosis of the Pancreas , J. Chron. Dis. 7:58-90, 1958.Crossref 3. Bodian, M.: Fibrocystic Disease of the Pancreas: A Congenital Disorder of Mucus Production-Mucosis , London, William Heinemann Medical Books, Ltd., 1952. 4. Shwachman, H.; Leubner, H., and Catzel, P.: Mucoviscidosis , in Advances in Pediatrics , edited by S. Z. Levine, Chicago, The Year Book Publishers, Inc., 1955, pp. 249-323. 5. Neuhauser, E. B. D.: Roentgen Changes Associated with Pancreatic Insufficiency in Early Life , Radiology 46:319-328, 1946.Crossref 6. di Sant'Agnese, P. A.: Fibrocystic Disease of the Pancreas with Normal or Partial Pancreatic Function: Current Views on Pathogenesis and Diagnosis , Pediatrics 15:683-697, 1955. 7. Shwachman, H., and Kulczycki, L.: Long-Term Study of One Hundred Five Patients with Cystic Fibrosis , A.M.A.J. Dis. Child. 96:6-15, 1958.Crossref 8. Wu, H.: A New Colorimetric Method for the Determination of Plasma Proteins , J. Biol. Chem. 51:33-39, 1922. 9. Shapiro, S., and Weiner, M.: Coagulation, Thrombosis, and Dicumarol , New York, Brooklyn Medical Press, 1949, p. 106. 10. Sia, R. H. P., and Wu, H.: Serum Globulin in Kala-Azar , China M.J. 35:527-532, 1921. 11. Sia, R. H. P.: A Simple Method for Estimating Quantitative Differences in the Globulin Precipitation Test in Kala-Azar , China M.J. 38:35-42, 1924. 12. Kabat, E. A.; Moore, D. H., and Landow, H.: An Electrophoretic Study of the Protein Components in Cerebrospinal Fluid and their Relationship to the Serum Proteins , J. Clin. Invest. 21:571-577, 1942.Crossref 13. Katzenelbogen, S.: The Cerebrospinal Fluid and Its Relation to the Blood: A Physiological and Clinical Study , Baltimore, Johns Hopkins Press, 1935. 14. Yahr, M. D.; Goldensohn, S. S., and Kabat, E. A.: Further Studies on the Gamma Globulin Content of Cerebrospinal Fluid in Multiple Sclerosis and Other Neurological Diseases , Annals of N.Y. Acad. Sc. 58:613-624, 1954.Crossref 15. Austen, F. K.; Carmichael, M. W., and Adams, R. D.: Neurologic Manifestations of Chronic Pulmonary Insufficiency , New England J. Med. 257:579-590, 1957.Crossref 16. Bass, M. H.: The Relation of Vitamin A Intake to Cerebrospinal Fluid Pressure: A Review , J. Mt. Sinai Hosp., New York 24:713-719, 1957. 17. Waldenström, J.: Macroglobulinemia, Triangle ; The Sandoz J.M. Sc. 3:262-270, 1958.

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A.M.A. Archives of Ophthalmology – American Medical Association

Published: Mar 1, 1960

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