Access the full text.
Sign up today, get DeepDyve free for 14 days.
Thirteenth Edition, Laurence Brunton (1941)
The Pharmacological Basis of TherapeuticsNature, 148
J. McMichael (1954)
Ciba Foundation Symposium
J. Moyer, H. Snyder, I. Johnson, L. Mills, Sam Miller (1953)
RESULTS WITH ORAL HEXAMETHONIUM ALONE AND IN COMBINATION WITH 1‐HYDRAZINOPHTHALAZINE (APRESOLINE) IN THE THERAPY OF HYPERTENSIONThe American Journal of the Medical Sciences, 225
K. Smith, P. Fowler, V. Edmunds (1954)
Hypertension and its Control by HexamethoniumBritish Medical Journal, 2
(1952)
Preliminary report on use of methonium com - pouinds and general anesthesia in ophthalmic surgery
A. Cameron, R. Burn (1952)
Hexamethonium and Glaucoma *British Journal of Ophthalmology, 36
K. Gurling (1955)
Evaluation of an Androgen, Methylandrostenediol, in the Treatment of Diabetic Retinopathy *British Journal of Ophthalmology, 39
P. Beaconsfield (1952)
[Dangers of using hexamethonium in medicine and surgery].La Presse medicale, 60 37
W. Duke-Elder (1935)
TEXT BOOK OF OPHTHALMOLOGYOptometry and Vision Science, 12
F. Ferrara (1954)
[Hexamethonium in the treatment of arterial hypertension].La Semana medica, 104 10
Rønnov-Jessen (1954)
Hexamethonium treatment of arterial hypertension.Danish Medical Bulletin, 1
R. Hilker , P. Rhoads (1953)
Clinical Use of Hydralazine and Hexamethonium in Treatment of HypertensionJ. A. M. A., 153
A. Couadau (1952)
Effects of Various Anesthetics, Curare and Ganglioplegic DrugsArch. opht., 12
Lessons from hexamethonitim stuidies in maligniant hypertension
W. Paton (1952)
Methonium CompoundsPharmacol. Rev., 4
(1952)
Ocular effects of methonitum compounids ( quaternary ammonium compounds )
Outpatient treatment of hypertension with hexamethonitmm and hydralazine
R. Turner (1950)
The Methonium CompoundsBritish Medical Journal, 1
R. Shackman, I. Graber, D. Melrose, J. Smith (1952)
HÆMODYNAMICS OF METHONIUM HYPOTENSION DURING ANÆSTHESIAAnaesthesia, 7
H. Schroeder (1953)
The Control of Arterial Hypertension by HyphexM. Clin. North America, 37
Effects of variotus anesthetics, curare and ganglion blocking
P. Beaconsfield (1952)
Dangers in Use of Hexamethonium in Medicine and SurgeryPresse méd., 60
(1952)
Hexamethonium ( quaterniary ammontitum compound ) anid glauicomiia
A. Goldsmith, A. Hewer (1952)
Unilateral Amaurosis with Partial Recovery after Using Hexamethonium IodideBritish Medical Journal, 2
M. Moser, J. Syner, S. Malitz, T. Mattingly (1953)
Acute psychosis as a complication of hydralazine therapy in essential hypertension.Journal of the American Medical Association, 152 14
H. Schroeder, J. Morrow (1953)
The control of arterial hypertension by hyphex, with an evaluation of other methods of therapy.The Medical clinics of North America, 1 Nationwide Number
R. Hilker, P. Rhoads, C. Billings (1953)
Clinical use of hydralazine and hexamethonium in treatment of hypertension.Journal of the American Medical Association, 153 1
M. Moser , J. Syner, S. Malitz (1953)
Acute Psychosis as a Complication of Hydralazine Therapy in Essential HypertensionJ. A. M. A., 152
Abstract Hexamethonium chloride is a quaternary ammonium halide. Its formula is: Sometimes the bromide is employed and in England the iodide is preferred, but the chloride is the most commonly used salt. In the United States hexamethonium is sold as Methium (Warner-Chilcott Laboratories), Hexameton (Burroughs Wellcome & Company), Esomid (Ciba Pharmaceutical Products, Inc.), Bistrium (E. R. Squibb & Sons), and others. It is also combined with such antihypertensive drugs as hydralazine (Apresoline) and rauwolfine. The tetra-, penta-, and hexamethonium compounds act by blocking both the sympathetic and the parasympathetic ganglia. The block, which is carried out by competition, occurs at the synapse. Vasoconstriction and autonomie tone are thereby reduced or abolished. In addition to use of hexamethonium in hypertension, the drug is being widely used in surgery, particularly in extensive operations, to diminish bleeding. As might be expected in a drug that may cause a fall of blood pressure from 260/160 References 1. It has been used mixed in the same syringe with insulin in the treatment of hypertensive diabetics with "diabetic nephropathy." 9 2. Galen, W., and Duke, J.: Outpatient Treatment of Hypertension with Hexamethonium and Hydralazine , South. M. J. 47:858 ( (Sept.) ) 1954.Crossref 3. Rjzinnov-Jessen, V.: Hexamethonium Treatment of Arterial Hypertension , Danish M. Bull. 1:106 ( (Aug.) ) 1954. 4. Hilker, R.; Rhoads, P., and Billings, C.: Clinical Use of Hydralazine and Hexamethonium in Treatment of Hypertension , J. A. M. A. 153:5 ( (Sept. 5) ) 1953.Crossref 5. Beaconsfield, P.: Dangers in Use of Hexamethonium in Medicine and Surgery , Presse méd. 60:811 ( (May 31) ) 1952. 6. Smith, K.; Fowler, P., and Edmunds, V.: Hypertension and Its Control by Hexamethonium , Brit. M. J. 2:1243 ( (Nov. 27) ) 1954.Crossref 7. Schroeder, H., and Morrow, L.: The Control of Arterial Hypertension by Hyphex , M. Clin. North America 37:991 ( (July) ) 1953. 8. Moyer, J.; Snyder, H. B.; Johnson, I.; Mills, L. C, and Miller, S. L: Results with Oral Hexamethonium Alone and in Combination with 1-Hydrazinophthalazine (Apresoline) in the Therapy of Hypertension , Am. J. M. Sc. 225:379 ( (April) ) 1953.Crossref 9. Moser, M.; Syner, J.; Malitz, S., and Mattingly, T.: Acute Psychosis as a Complication of Hydralazine Therapy in Essential Hypertension , J. A. M. A. 152:1329 ( (Aug. 1) ) 1953.Crossref 10. Gurling, K.: Evaluation of an Androgen, Methylandrostenediol, in the Treatment of Diabetic Retinopathy , Brit. J. Ophth. 39: 151 ( (March) ) 1955. 11. Goldsmith, A., and Hewer, A.: Unilateral Amaurosis with Partial Recovery After Using Hexamethonium Iodide , Brit. M. J. 2:759 ( (Oct. 4) ) 1952.Crossref 12. Cameron, A., and Burn, R.: Hexamethonium and Glaucoma , Brit. J. Ophth. 36:482 ( (Sept.) ) 1952.Crossref 13. Rycroft, B., and Romanes, G.: Preliminary Report on Use of Methonium Compounds and General Anaesthesia in Ophthalmic Surgery , Brit. J. Ophth. 36:29 ( (Jan.) ) 1952.Crossref 14. Couadau, A., and Campan, L.: Effects of Various Anesthetics, Curare and Ganglioplegic Drugs , Arch. opht. 12:287, 1952. 15. Barnett, A.: Ocular Effects of Methonium Compounds (Quaternary Ammonium Compounds) , Brit. J. Ophth. 36:593 ( (Nov.) ) 1952.Crossref 16. McMichael, J.: Lessons from Hexamethonium Studies in Malignant Hypertension, in Hypertension , edited by G. E. W. Wolstenholme, Ciba Foundation Symposium , Boston, Little, Brown & Company, 1954, p. 193. 17. Goodman, L. S., and Gilman, A.: The Pharmacological Basis of Therapeutics , Edition 2, New York, The Macmillan Company, 1955. 18. Paton, W., and Zaimis, E.: Methonium Compounds , Pharmacol. Rev. 4:219 ( (Sept.) ) 1952. 19. Shackman, R.; Graber, I.; Melrose, D., and Smith, J.: Haemodynamics of Methonium Hypotension During Anaesthesia , Anaesthesia 7:217 ( (Oct.) ) 1952.Crossref 20. Duke-Elder, W. S.: Text-Book of Ophthalmology , Vol. Ill, St. Louis, C. V. Mosby Company, 1941, p. 2556.
A.M.A. Archives of Ophthalmology – American Medical Association
Published: Sep 1, 1955
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.