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A. Bakker (1947)
THE ACTION OF SULPHANILAMIDE ON RABBITS' LENSES IN VITRO*†British Journal of Ophthalmology, 31
T. H. Maren (1954)
Relation Between the Pharmacological Disposition and the Renal Effects of Diamox (a-Acetylamino-1, 3, 4-Thiadiazole-5-Sulfonamide), a Carbonic Anhydrase InhibitorJ. Pharmacol. & Exper. Therap., 110
R. Roblin, J. Clapp (1950)
The Preparation of Heterocyclic Sulfonamides1Journal of the American Chemical Society, 72
V. E. Kinsey (1950)
A Unified Concept of Aqueous Humor Dynamics and the Maintenance of Intraocular PressureA. M. A. Arch. Ophth., 44
B. Becker (1954)
Decrease in Intraocular Pressure in Man by a Carbonic Anhydrase Inhibitor, DiamoxAm. J. Ophth., 37
B. Mansheim (1953)
Aqueous outflow measurements by continuous tonometry in some unusual forms of glaucoma.A.M.A. archives of ophthalmology, 50 5
R. Pitts, R. Alexander (1945)
THE NATURE OF THE RENAL TUBULAR MECHANISM FOR ACIDIFYING THE URINEAmerican Journal of Physiology, 144
P. Wistrand (1951)
Carbonic anhydrase in the anterior uvea of the rabbit.Acta physiologica Scandinavica, 24 2-3
C. Friedberg, R. Taymor, J. Minor, M. Halpern (1953)
The use of diamox, a carbonic anhydrase inhibitor, as an oral diuretic in patients with congestive heart failure.The New England journal of medicine, 248 21
T. Maren (1952)
Pharmacological and renal effects of diamox (6063), a new carbonic anhydrase inhibitor.Transactions of the New York Academy of Sciences, 15 2
J. S. Friedenwald (1949)
Formation of the Intraocular FluidAm. J. Ophth., 32
V. E. Kinsey (1953)
Comparative Chemistry of Aqueous Humor in Posterior and Anterior Chambers of Rabbit EyesA. M. A. Arch. Ophth., 50
sdance consacr6e, A. Bakker, Carbonic Anhydrase, Cataracta Lentis (1948)
CARBONIC ANHYDRASE AND CATARACTA LENTIS*British Journal of Ophthalmology, 32
B. Becker (1954)
Decrease in intraocular pressure in man by a carbonic anhydrase inhibitor, diamox; a preliminary report.American journal of ophthalmology, 37 1
Wilbur Miller, A. Dessert, R. Roblin (1950)
Heterocyclic Sulfonamides as Carbonic Anhydrase Inhibitors1Journal of the American Chemical Society, 72
T. H. Maren (1954)
Blocking of the Renal Effect of Diamox (2-Acetylamino-1, 3, 4-Thiadiazole-5-Sulfonamide) by Metabolic AcidosisFed. Proc., 13
B. J. Mansheim (1953)
Aqueous Outflow Measurements by Continuous Tonometry in Some Unusual Forms of GlaucomaA. M. A. Arch. Ophth., 50
Abstract THE FOLLOWING study on the treatment of glaucoma with the carbonic anhydrase inhibitor acetazoleamide ( 2-acetylamino-1,3,4-thiadiazole-5-sulfonamide; Diamox) was initiated in October, 1953, and covers a four-month period of observation. Inhibition of carbonic anhydrase by acetazoleamide is a new and useful means of lowering the intraocular pressure. Acetazoleamide, a heterocyclic sulfonamide, was developed by Roblin and associates, in 1950,* as a diuretic agent whose action was based on inhibition of carbonic anhydrase in the renal tubular epithelium. Carbonic anhydrase catalyzes the hydration of carbon dioxide to form carbonic acid: H2O+CO2⇄ H2CO3. The carbonic acid dissociates to form H+ and HCO3-. Thus, the level of hydrogen ions and bicarbonate ions is affected by this enzyme. In the kidney there ensues a hydrogen-sodium exchange between the tubular epithelium and the glomerular filtrate, resulting in the normal conservation of base and the formation of an acid urine. References 1. References 1 and 2. 2. Maren, T. H.: Personal communication to the authors. 3. Roblin, R. O., Jr., and Clapp, J. W.: Preparation of Heterocyclic Sulfonamides , J. Am. Chem. Soc. 72:4890, 1950.Crossref 4. Miller, W. H.; Dessert, A. M., and Roblin, R. O., Jr.: Heterocyclic Sulfonamides as Carbonic Anhydrase Inhibitors , J. Am. Chem. Soc. 72:4893, 1950.Crossref 5. Pitts, R. F., and Alexander, R. S.: Nature of the Renal Tubular Mechanism for Acidifying the Urine , Am. J. Physiol. 144:239, 1945. 6. Maren, T. H.: Pharmacological and Renal Effects of Diamox (6063), a New Carbonic Anhydrase Inhibitor , Tr. New York Acad. Sc. 15:53, 1952.Crossref 7. Friedberg, C. K.; Taymor, R.; Minor, J. B., and Halpern, M.: Use of Diamox, a Carbonic Anhydrase Inhibitor, as an Oral Diuretic in Patients with Congestive Heart Failure , New England J. Med. 248:883, 1953.Crossref 8. Kinsey, V. E.: Comparative Chemistry of Aqueous Humor in Posterior and Anterior Chambers of Rabbit Eyes , A. M. A. Arch. Ophth. 50:401, 1953.Crossref 9. Friedenwald, J. S.: Formation of the Intraocular Fluid , Am. J. Ophth. 32:9 (June, (Pt. 2) ) 1949. 10. Westrand, P. J.: Carbonic Anhydrase in the Anterior Uvea of the Rabbit , Acta physiol. scandinav. 24:144, 1951.Crossref 11. Bakker, A.: Carbonic Anhydrase and Cataracta Lentis , Brit. J. Ophth. 32:910, 1948.Crossref 12. Bakker, A.: Action of Sulphanilamide on Rabbits' Lenses in Vitro , Brit. J. Ophth. 31:216, 1947.Crossref 13. Kinsey, V. E.: A Unified Concept of Aqueous Humor Dynamics and the Maintenance of Intraocular Pressure , A. M. A. Arch. Ophth. 44:215, 1950.Crossref 14. Mansheim, B. J.: Aqueous Outflow Measurements by Continuous Tonometry in Some Unusual Forms of Glaucoma , A. M. A. Arch. Ophth. 50:580, 1953.Crossref 15. Maren, T. H., and Wadsworth, B. C.: Relation Between the Pharmacological Disposition and the Renal Effects of Diamox (a-Acetylamino-1, 3, 4-Thiadiazole-5-Sulfonamide), a Carbonic Anhydrase Inhibitor , J. Pharmacol. & Exper. Therap. 110:34, 1954. 16. Maren, T. H.: Blocking of the Renal Effect of Diamox (2-Acetylamino-1, 3, 4-Thiadiazole-5-Sulfonamide) by Metabolic Acidosis , Fed. Proc. 13:383, 1954. 17. Becker, B.: Decrease in Intraocular Pressure in Man by a Carbonic Anhydrase Inhibitor, Diamox , Am. J. Ophth. 37:13, 1954.
A.M.A. Archives of Ophthalmology – American Medical Association
Published: Sep 1, 1954
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