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DIBENAMINE: An Experimental and Clinical Study

DIBENAMINE: An Experimental and Clinical Study Abstract DIBENAMINE is a nitrogen mustard derivative, first introduced by Nickerson1 in 1946, which possesses specific and highly potent sympatholytic and adrenolytic properties. Nickerson and Goodman2 subsequently elaborated upon the pharmacological characteristics of the substance. Ophthalmologic interest in the drug was stimulated in 1948 by Christensen, Swan, and Gould,3 who reported favorable effects in the treatment of acute glaucoma with Dibenamine. This paper presents certain experimental data concerned with the mechanism of action of Dibenamine in lowering intraocular pressure and our experiences with the drug in the treatment of a small number of patients with acute glaucoma. PURPOSE OF EXPERIMENTS The way in which Dibenamine lowers the intraocular pressure in glaucoma has never been determined. We felt that several possibilities should be investigated and devoted our experimental studies to the following factors: (1) alterations in the permeability of the blood-aqueous barrier; (2) changes in rate of flow of References 1. Nickerson, M., and Goodman, L. S.: Physiological Properties of a New Series of Sympatholytic Agents , Federation Proc. ( (Pt. 2) ) 5:194, 1946. 2. Nickerson, M., and Goodman, L. S.: Pharmacological and Physiological Aspects of Adrenergic Blockade with Special Reference to Dibenamine , Federation Proc. 7:397,1948. 3. Nickerson, M.: Interpretation of Experimental Results Obtained with Dibenamine , Endocrinology 44:287, 1949.Crossref 4. Christensen, L.; Swan, K. C., and Gould, J.: Hypotensive Action of Dibenamine in Glaucoma , Northwest Med. 47:731, 1948. 5. Rigdon, R. H., and Wilson, H.: Capillary Permeability and Inflammation in Rabbits Given Heparin , Arch. Surg. 43:64, 1941.Crossref 6. Dibenamine was supplied by Smith, Kline & French Laboratories, Philadelphia. 7. Marzoni, F. A.; Reardon, M. J.; Hendrix, J. P., and Grimson, K. S.: A Comparison of Sympatholytic Effects of Priscol, Etamon, and Dibenamine in Dogs with Results of Actual Sympathectomy , Surgery 26:117, 1949. 8. de Vleeschhouwer, G. R.: Pharmacology of Dibenzyl-β-Chloroethylamine Hydrochloride (Dibenamine) , Proc. Soc. Biol. & Med. 66:151, 1947. 9. Bárány, E., and Kinsey, E. V.: The Rate of Flow of Aqueous Humor: Rate of Disappearance of Paraaminohippuric Acid, Radioactive Rayopake, and Radioactive Diodrast from Aqueous Humor of Rabbits , Am. J. Ophth. 32:177, (June (Pt. 2) ) 1949. 10. Swan, K. C., and Hart, W. M. Comparative Study of Effects of Mecholyl, Doryl, Eserine, Pilocarpine, Atropine, and Epinephrine on the Blood- Aqueous Barrier , Am. J. Ophth. 23:1311, 1940. 11. Leber, T.: Die Zirkulations- und Ehrnährungsverhältnisse des Auges , in von Theodor-Saemisch: Handbuch der gesamten Augenheilkunde , Ed. 2, Leipzig, Wilhelm Engelmann, 1903. 12. Ross, E. J.: Circulation of the Aqueous Humor and the Experimental Determination of Its Rate of Flow , Brit. J. Ophth. 36:41, 1952. 13. Scheie, H. G., and Frayer, W. C.: Ocular Hypertension Induced by Air in the Anterior Chamber , Arch. Ophth. 44:691, 1950. 14. Barkan, O.: Glaucoma Induced by Air Blockade , Am. J. Ophth. 34:567, 1951. 15. Mullen, C. R., and Leopold, I. H.: Adrenergic Blocking Agents in Treatment of Glaucoma , A. M. A. Arch. Ophth. 46:549, 1951. 16. Friedenwald, J. S., and Buschke, W.: Role of Epinephrine in Formation of Intraocular Fluid , Am. J. Ophth. 24:1105, 1941. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Ophthalmology American Medical Association

DIBENAMINE: An Experimental and Clinical Study

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References (15)

Publisher
American Medical Association
Copyright
Copyright © 1953 American Medical Association. All Rights Reserved.
ISSN
0096-6339
DOI
10.1001/archopht.1953.00920030296005
Publisher site
See Article on Publisher Site

Abstract

Abstract DIBENAMINE is a nitrogen mustard derivative, first introduced by Nickerson1 in 1946, which possesses specific and highly potent sympatholytic and adrenolytic properties. Nickerson and Goodman2 subsequently elaborated upon the pharmacological characteristics of the substance. Ophthalmologic interest in the drug was stimulated in 1948 by Christensen, Swan, and Gould,3 who reported favorable effects in the treatment of acute glaucoma with Dibenamine. This paper presents certain experimental data concerned with the mechanism of action of Dibenamine in lowering intraocular pressure and our experiences with the drug in the treatment of a small number of patients with acute glaucoma. PURPOSE OF EXPERIMENTS The way in which Dibenamine lowers the intraocular pressure in glaucoma has never been determined. We felt that several possibilities should be investigated and devoted our experimental studies to the following factors: (1) alterations in the permeability of the blood-aqueous barrier; (2) changes in rate of flow of References 1. Nickerson, M., and Goodman, L. S.: Physiological Properties of a New Series of Sympatholytic Agents , Federation Proc. ( (Pt. 2) ) 5:194, 1946. 2. Nickerson, M., and Goodman, L. S.: Pharmacological and Physiological Aspects of Adrenergic Blockade with Special Reference to Dibenamine , Federation Proc. 7:397,1948. 3. Nickerson, M.: Interpretation of Experimental Results Obtained with Dibenamine , Endocrinology 44:287, 1949.Crossref 4. Christensen, L.; Swan, K. C., and Gould, J.: Hypotensive Action of Dibenamine in Glaucoma , Northwest Med. 47:731, 1948. 5. Rigdon, R. H., and Wilson, H.: Capillary Permeability and Inflammation in Rabbits Given Heparin , Arch. Surg. 43:64, 1941.Crossref 6. Dibenamine was supplied by Smith, Kline & French Laboratories, Philadelphia. 7. Marzoni, F. A.; Reardon, M. J.; Hendrix, J. P., and Grimson, K. S.: A Comparison of Sympatholytic Effects of Priscol, Etamon, and Dibenamine in Dogs with Results of Actual Sympathectomy , Surgery 26:117, 1949. 8. de Vleeschhouwer, G. R.: Pharmacology of Dibenzyl-β-Chloroethylamine Hydrochloride (Dibenamine) , Proc. Soc. Biol. & Med. 66:151, 1947. 9. Bárány, E., and Kinsey, E. V.: The Rate of Flow of Aqueous Humor: Rate of Disappearance of Paraaminohippuric Acid, Radioactive Rayopake, and Radioactive Diodrast from Aqueous Humor of Rabbits , Am. J. Ophth. 32:177, (June (Pt. 2) ) 1949. 10. Swan, K. C., and Hart, W. M. Comparative Study of Effects of Mecholyl, Doryl, Eserine, Pilocarpine, Atropine, and Epinephrine on the Blood- Aqueous Barrier , Am. J. Ophth. 23:1311, 1940. 11. Leber, T.: Die Zirkulations- und Ehrnährungsverhältnisse des Auges , in von Theodor-Saemisch: Handbuch der gesamten Augenheilkunde , Ed. 2, Leipzig, Wilhelm Engelmann, 1903. 12. Ross, E. J.: Circulation of the Aqueous Humor and the Experimental Determination of Its Rate of Flow , Brit. J. Ophth. 36:41, 1952. 13. Scheie, H. G., and Frayer, W. C.: Ocular Hypertension Induced by Air in the Anterior Chamber , Arch. Ophth. 44:691, 1950. 14. Barkan, O.: Glaucoma Induced by Air Blockade , Am. J. Ophth. 34:567, 1951. 15. Mullen, C. R., and Leopold, I. H.: Adrenergic Blocking Agents in Treatment of Glaucoma , A. M. A. Arch. Ophth. 46:549, 1951. 16. Friedenwald, J. S., and Buschke, W.: Role of Epinephrine in Formation of Intraocular Fluid , Am. J. Ophth. 24:1105, 1941.

Journal

A.M.A. Archives of OphthalmologyAmerican Medical Association

Published: Sep 1, 1953

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