Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

EXPERIMENTAL STUDIES ON THE BLOOD-AQUEOUS BARRIER: II. Electrophotometric Measurements of Fluorescein Content of Aqueous After Intravenous Injection of Fluorescein, the Eye Being Under the Influence of Physostigmine, Pilocarpine, Neostigmine or Atropine1

EXPERIMENTAL STUDIES ON THE BLOOD-AQUEOUS BARRIER: II. Electrophotometric Measurements of... Abstract IT HAS been demonstrated by numerous authors, especially by the splendid work of Duke-Elder2 and Friedenwald3 and their co-workers, that the penetration of the various constituents of aqueous through the blood-aqueous barrier follows a rather complicated scheme. Electric charge, size of the molecule and possibly other factors influence the ratio of transmission of each constituent. But, on the other hand, it has also been shown that any change of the permeability of the blood-aqueous barrier will affect all constituents to a certain extent, though not equally, whether they are electrolytes, nonelectrolytes or proteins. To mention only two examples, Krause, Yudkin, Stevens, Burmell and Hughson4 found an increase in the amount of arsenic present in the aqueous after intravenous injection of arsphenamines if the eye had been previously pilocarpinized, and Adler5 demonstrated a decrease in the permeability of the blood-aqueous barrier to protein in spite of the References 1. Stocker, F. W.: Experimental Studies on the Blood-Aqueous Barrier: I. New Electrophotometric Method of Measuring the Concentration of Fluorescein in the Aqueous , Arch. Ophth. 36:612 ( (Nov.) ) 1946.Crossref 2. Duke-Elder, S., and Davson, H.: The Significance of the Distribution Ratios of Nonelectrolytes Between Plasma and the Intraocular Fluid , Brit. J. Ophth. 27:432, 1943.Crossref 3. Duke-Elder, S.; Quilliam, J. C., and Davson, H.: Some Observations on the Present Position of Our Knowledge of the Intraocular Fluid , Brit. J. Ophth. 24:421, 1940.Crossref 4. Friedenwald, J. S.: Dynamic Factors in the Formation and Reabsorption of Aqueous Humor , Brit. J. Ophth. 28:503, 1944.Crossref 5. Friedenwald, J. S., and Stiehler, R. D. : Circulation of the Aqueous : VII. A Mechanism of Secretion of the Intraocular Fluid , Arch. Ophth. 20:761 ( (Nov.) ) 1938.Crossref 6. Krause, A. C.; Yudkin, A. M.; Stevens, M. A.; Burmell, W. W., and Hughson, D. T.: The Influence of Drugs on the Transmission of Arsenic into the Aqueous Humor , J. Pharmacol. & Exper. Therap. 39:153, 1930. 7. Adler, F. H.: The Action of Atropine in Ocular Inflammations , Arch. Ophth. 55:484 ( (Sept.) ) 1926. 8. Kinsey, V. E.; Grant, M., and Cogan, D. : Water Movement and the Eye , Arch. Ophth. 27:242 ( (Feb.) ) 1942. 9. Seidel, E.: Ueber den Vorgang der physiologischen Kammerwasserabsonderung und seine pharmakologische Beeinflussung , Arch. f. Ophth. 102:366, 1920. 10. Swan, K. C., and Hart, W. M.: A Comparative Study of the Effects of Mecholyl, Doryl, Eserine, Pilocarpine, Atropine and Epinephrine on the Blood-Aqueous Barrier , Am. J. Ophth. 23:1311, 1940. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

EXPERIMENTAL STUDIES ON THE BLOOD-AQUEOUS BARRIER: II. Electrophotometric Measurements of Fluorescein Content of Aqueous After Intravenous Injection of Fluorescein, the Eye Being Under the Influence of Physostigmine, Pilocarpine, Neostigmine or Atropine1

STOCKER, FREDERICK W.
Archives of Ophthalmology , Volume 37 (5) – May 1, 1947
Download PDF
4 pages

Loading next page...
 
/lp/american-medical-association/experimental-studies-on-the-blood-aqueous-barrier-ii-wzCeZgRvRQ

References (10)

Publisher
American Medical Association
Copyright
Copyright © 1947 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1947.00890220600003
Publisher site
See Article on Publisher Site

Abstract

Abstract IT HAS been demonstrated by numerous authors, especially by the splendid work of Duke-Elder2 and Friedenwald3 and their co-workers, that the penetration of the various constituents of aqueous through the blood-aqueous barrier follows a rather complicated scheme. Electric charge, size of the molecule and possibly other factors influence the ratio of transmission of each constituent. But, on the other hand, it has also been shown that any change of the permeability of the blood-aqueous barrier will affect all constituents to a certain extent, though not equally, whether they are electrolytes, nonelectrolytes or proteins. To mention only two examples, Krause, Yudkin, Stevens, Burmell and Hughson4 found an increase in the amount of arsenic present in the aqueous after intravenous injection of arsphenamines if the eye had been previously pilocarpinized, and Adler5 demonstrated a decrease in the permeability of the blood-aqueous barrier to protein in spite of the References 1. Stocker, F. W.: Experimental Studies on the Blood-Aqueous Barrier: I. New Electrophotometric Method of Measuring the Concentration of Fluorescein in the Aqueous , Arch. Ophth. 36:612 ( (Nov.) ) 1946.Crossref 2. Duke-Elder, S., and Davson, H.: The Significance of the Distribution Ratios of Nonelectrolytes Between Plasma and the Intraocular Fluid , Brit. J. Ophth. 27:432, 1943.Crossref 3. Duke-Elder, S.; Quilliam, J. C., and Davson, H.: Some Observations on the Present Position of Our Knowledge of the Intraocular Fluid , Brit. J. Ophth. 24:421, 1940.Crossref 4. Friedenwald, J. S.: Dynamic Factors in the Formation and Reabsorption of Aqueous Humor , Brit. J. Ophth. 28:503, 1944.Crossref 5. Friedenwald, J. S., and Stiehler, R. D. : Circulation of the Aqueous : VII. A Mechanism of Secretion of the Intraocular Fluid , Arch. Ophth. 20:761 ( (Nov.) ) 1938.Crossref 6. Krause, A. C.; Yudkin, A. M.; Stevens, M. A.; Burmell, W. W., and Hughson, D. T.: The Influence of Drugs on the Transmission of Arsenic into the Aqueous Humor , J. Pharmacol. & Exper. Therap. 39:153, 1930. 7. Adler, F. H.: The Action of Atropine in Ocular Inflammations , Arch. Ophth. 55:484 ( (Sept.) ) 1926. 8. Kinsey, V. E.; Grant, M., and Cogan, D. : Water Movement and the Eye , Arch. Ophth. 27:242 ( (Feb.) ) 1942. 9. Seidel, E.: Ueber den Vorgang der physiologischen Kammerwasserabsonderung und seine pharmakologische Beeinflussung , Arch. f. Ophth. 102:366, 1920. 10. Swan, K. C., and Hart, W. M.: A Comparative Study of the Effects of Mecholyl, Doryl, Eserine, Pilocarpine, Atropine and Epinephrine on the Blood-Aqueous Barrier , Am. J. Ophth. 23:1311, 1940.

Journal

Archives of Ophthalmology – American Medical Association

Published: May 1, 1947

There are no references for this article.