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EXPERIMENTAL STUDIES ON THE BLOOD-AQUEOUS BARRIER: I. New Electrophotometric Method of Measuring the Concentration of Fluorescein in the Aqueous

EXPERIMENTAL STUDIES ON THE BLOOD-AQUEOUS BARRIER: I. New Electrophotometric Method of Measuring... Abstract THE exchange of water and other substances between the blood and the contents of the eye is not only an interesting physiologic and biochemical phenomenon but also a vital factor for the maintenance of the intraocular pressure on a certain level. In order to understand better the abnormal variations of the intraocular pressure, one should know as much as possible about the normal mechanism of the exchange of fluid between the blood and the eye, the rate of inflow of the fluid and how this rate may be changed under various conditions. Several attempts have been made to supply the blood with a tracer substance, the presence of which could be demonstrated in the aqueous after having passed through the blood-aqueous barrier. As far back as 1882 Paul Ehrlich1 discovered that fluorescein injected into a rabbit's vein will appear in the aqueous after a comparatively short time. However, a References 1. Ehrlich, P.: Ueber provocierte Fluorescenzerscheinungen am Auge , Deutsche med. Wchnschr. 8:21, 35 and 54, 1882.Crossref 2. Leber, T., cited by Hertel.5 3. Wessely, K.: Der Flüssigkeits-und Stoffwechsel des Auges mit besonderer Berüchsichtigung seiner Beziehungen zu allgemein physiologischen und biologischen Fragen , Ergebn. d. Physiol. 4:626, 1905.Crossref 4. Yoshida, Y.: Ueber Wechselbeziehungen zwischen Blut und Kammerwasser , Arch. f. Augenh. 100:470, 1929. 5. Hertel, E.: Ueber die Bedeutung der Ehrlichschen Fluoreszeinversuche , Arch. f. Augenh. 100-101:460, 1929. 6. de Haan, J., and van Creveld, S.: Ueber die Wechselbeziehungen zwischen Blutplasma und Gewebsflüssigkeiten, insbesondere Kammerwasser und Cerebrospinalflüssigkeit , Biochem. Ztschr. 123:190, 1921. 7. Kinsey, V. E.; Grant, M., and Cogan, D. G.: Water Movement and the Eye , Arch. Ophth. 27:242 ( (Feb.) ) 1942.Crossref 8. Kinsey, V. E.: Grant, W. M.; Cogan, D. G.; Livingood, J. J., and Curtis, B. R.: Sodium, Chloride and Phosphorus Movement and the Eye , Arch. Ophth. 27:1126 ( (June) ) 1942.Crossref 9. Manufactured by the Colman Co., Inc., Maywood, Ill. 10. Duke-Elder, W. S.: The Nature of the Intraocular Fluids , British Journal of Ophthalmology Monograph Supplement 3 , London, George Pulman and Sons, Ltd., 1927. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

EXPERIMENTAL STUDIES ON THE BLOOD-AQUEOUS BARRIER: I. New Electrophotometric Method of Measuring the Concentration of Fluorescein in the Aqueous

Archives of Ophthalmology , Volume 36 (5) – Nov 1, 1946

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References (8)

Publisher
American Medical Association
Copyright
Copyright © 1946 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1946.00890210622005
Publisher site
See Article on Publisher Site

Abstract

Abstract THE exchange of water and other substances between the blood and the contents of the eye is not only an interesting physiologic and biochemical phenomenon but also a vital factor for the maintenance of the intraocular pressure on a certain level. In order to understand better the abnormal variations of the intraocular pressure, one should know as much as possible about the normal mechanism of the exchange of fluid between the blood and the eye, the rate of inflow of the fluid and how this rate may be changed under various conditions. Several attempts have been made to supply the blood with a tracer substance, the presence of which could be demonstrated in the aqueous after having passed through the blood-aqueous barrier. As far back as 1882 Paul Ehrlich1 discovered that fluorescein injected into a rabbit's vein will appear in the aqueous after a comparatively short time. However, a References 1. Ehrlich, P.: Ueber provocierte Fluorescenzerscheinungen am Auge , Deutsche med. Wchnschr. 8:21, 35 and 54, 1882.Crossref 2. Leber, T., cited by Hertel.5 3. Wessely, K.: Der Flüssigkeits-und Stoffwechsel des Auges mit besonderer Berüchsichtigung seiner Beziehungen zu allgemein physiologischen und biologischen Fragen , Ergebn. d. Physiol. 4:626, 1905.Crossref 4. Yoshida, Y.: Ueber Wechselbeziehungen zwischen Blut und Kammerwasser , Arch. f. Augenh. 100:470, 1929. 5. Hertel, E.: Ueber die Bedeutung der Ehrlichschen Fluoreszeinversuche , Arch. f. Augenh. 100-101:460, 1929. 6. de Haan, J., and van Creveld, S.: Ueber die Wechselbeziehungen zwischen Blutplasma und Gewebsflüssigkeiten, insbesondere Kammerwasser und Cerebrospinalflüssigkeit , Biochem. Ztschr. 123:190, 1921. 7. Kinsey, V. E.; Grant, M., and Cogan, D. G.: Water Movement and the Eye , Arch. Ophth. 27:242 ( (Feb.) ) 1942.Crossref 8. Kinsey, V. E.: Grant, W. M.; Cogan, D. G.; Livingood, J. J., and Curtis, B. R.: Sodium, Chloride and Phosphorus Movement and the Eye , Arch. Ophth. 27:1126 ( (June) ) 1942.Crossref 9. Manufactured by the Colman Co., Inc., Maywood, Ill. 10. Duke-Elder, W. S.: The Nature of the Intraocular Fluids , British Journal of Ophthalmology Monograph Supplement 3 , London, George Pulman and Sons, Ltd., 1927.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Nov 1, 1946

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