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HOMATROPINE-PAREDRINE EMULSION AS A CYCLOPLEGIC

HOMATROPINE-PAREDRINE EMULSION AS A CYCLOPLEGIC Abstract In 1937 Myerson and Thau,1 in Boston, suggested that benzedrine sulfate might be useful in producing cycloplegia, since it produces excellent mydriatic action. Accepting this suggestion, Beach and McAdams,2 in Maine, set up a study of benzedrine sulfate and combined this drug with 1 per cent atropine sulfate solution and also 5 per cent homatropine hydrobromide solution. In a small number of cases these combinations were used as cycloplegics, and the authors concluded that the time required to obtain cycloplegia was decreased, while the recovery time for the patient was considerably reduced. In general about forty to sixty minutes was required for complete cycloplegia when atropine sulfate solution followed by benzedrine sulfate solution was employed. The work of Beach and McAdams was confirmed by Powell and Hyde,3 who in two articles reported good results from 2 per cent homatropine solution with 1 per cent benzedrine sulfate solution. References 1. Myerson, A., and Thau, W.: Human Autonomic Pharmacology , Arch. Ophth. 18:78-90 ( (July) ) 1937.Crossref 2. Beach, S. J., and McAdams, W. R.: Benzedrine in Refraction , Tr. Am. Ophth. Soc. 35:221-226, 1937 3. Benzedrine in Cycloplegia , Am. J. Ophth. 21:121-124 ( (Feb.) ) 1938. 4. Powell, L. S., and Hyde, M. E.: Effect of Benzedrine Sulfate Solution on Cycloplegia , J. Kansas M. Soc. 39:1-4 ( (Jan.) ) 1938 5. Action of Eserine Administration During Homatropine-Benzedrine Cycloplegia , Powell J. Kansas M. Soc. 39:57-59 ( (Feb.) ) 1938. 6. Tassman, I. S.: The Use of Paredrine in Cycloplegia , Am. J. Ophth. 21:1019-1024 ( (Sept.) ) 1938. 7. Shemeley, W. G., Jr. Paredrine Hydrobromide for Cycloplegia , Eye, Ear, Nose & Throat Monthly 18:279-282 ( (Oct.) ) 1939. 8. Weinman, E. B., and Fralick, F. B.: Comparative Study of Benzedrine, Paredrine and Cocaine with Homatropine as Cycloplegics , Am. J. Ophth. 23:172-178 ( (Feb.) ) 1940. 9. Tassman, I. S.: The Clinical Uses of Paredrine Hydrobromide in the Eye , Pennsylvania M. J. 44:191-194 ( (Nov.) ) 1940. 10. Thorne, F. H., and Murphy, H. S.: Cycloplegics , Arch. Ophth. 22:274-287 ( (Aug.) ) 1939. 11. (a) Abbott, W. O., and Henry, C. M.: Paredrine: A Clinical Investigation of a Sympathomimetic Drug , Am. J. M. Sc. 193:661-672 ( (May) ) 1937. 12. (b) Mayer, L. L.: Dilation of the Pupil for Ophthalmoscopic Examination , J. A. M. A. 113:38-39 ( (July 1) ) 1939. 13. (c) Laval, J.: Allergic Dermatitis and Conjunctivitis from Paredrine Hydrobromide , Arch. Ophth. 26:585-586 ( (Oct.) ) 1941. 14. Paredrine hydrobromide ophthalmic was used: paredrine hydrobromide 1 per cent in distilled water made tear isotonic with 2 per cent boric acid and preserved with merthiolate 1: 50,000. 15. The method used for the measurement of the residual accommodation was suggested by Dr. Elek Ludvigh II, of the Massachusetts Eye and Ear Infirmary. The patient was made emmetropic for distance with the necessary lenses. Jaeger 1 print was placed 50 cm. from the eye if the vision was 20/20, and a + 3 D. sphere was added to the emmetropic correction. The plus sphere was then decreased 0.25 D. at a time until the print could be made out. The result was usually found to be + 2 D. over the distance correction, and this amount of lense corresponded to the far point in terms of dioptric strength. Minus spheres were now added until the Jaeger print could not be made out. This was the near point. The difference between the far and the near point as expressed in diopters was the amount of residual accommodation. In this manner no movement of the printed matter was necessary. The size of the Jaeger print used depended on the amount of vision present in the eye when it was tested for distance. 16. Marron, J.: Cycloplegia and Mydriasis by Use of Atropine, Scopolamine and Homatropine-Paredrine , Arch. Ophth. 23:340-350 ( (Feb.) ) 1940. 17. Alvaro, M. E.: New Method of Producing Cycloplegia in Refraction , Bol. Soc. de med. e cir. de São Paulo 23:46-51 ( (Feb.) ) 1939. 18. Powell, L. S., and Hyde, M. E.: The Practical Use of Homatropine-Paredrine Cycloplegia , J. Kansas M. Soc. 40:251-254 ( (June) ) 1939. 19. Hartshorne, I.: The Art of Refraction , Eye, Ear, Nose & Throat Monthly 19:201-206 ( (Aug.) ) 1940. 20. Shemeley.5 Weinman.6 Tassman.7 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

HOMATROPINE-PAREDRINE EMULSION AS A CYCLOPLEGIC

YASUNA, ELTON
Archives of Ophthalmology , Volume 30 (1) – Jul 1, 1943
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References (18)

Publisher
American Medical Association
Copyright
Copyright © 1943 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1943.00880190105010
Publisher site
See Article on Publisher Site

Abstract

Abstract In 1937 Myerson and Thau,1 in Boston, suggested that benzedrine sulfate might be useful in producing cycloplegia, since it produces excellent mydriatic action. Accepting this suggestion, Beach and McAdams,2 in Maine, set up a study of benzedrine sulfate and combined this drug with 1 per cent atropine sulfate solution and also 5 per cent homatropine hydrobromide solution. In a small number of cases these combinations were used as cycloplegics, and the authors concluded that the time required to obtain cycloplegia was decreased, while the recovery time for the patient was considerably reduced. In general about forty to sixty minutes was required for complete cycloplegia when atropine sulfate solution followed by benzedrine sulfate solution was employed. The work of Beach and McAdams was confirmed by Powell and Hyde,3 who in two articles reported good results from 2 per cent homatropine solution with 1 per cent benzedrine sulfate solution. References 1. Myerson, A., and Thau, W.: Human Autonomic Pharmacology , Arch. Ophth. 18:78-90 ( (July) ) 1937.Crossref 2. Beach, S. J., and McAdams, W. R.: Benzedrine in Refraction , Tr. Am. Ophth. Soc. 35:221-226, 1937 3. Benzedrine in Cycloplegia , Am. J. Ophth. 21:121-124 ( (Feb.) ) 1938. 4. Powell, L. S., and Hyde, M. E.: Effect of Benzedrine Sulfate Solution on Cycloplegia , J. Kansas M. Soc. 39:1-4 ( (Jan.) ) 1938 5. Action of Eserine Administration During Homatropine-Benzedrine Cycloplegia , Powell J. Kansas M. Soc. 39:57-59 ( (Feb.) ) 1938. 6. Tassman, I. S.: The Use of Paredrine in Cycloplegia , Am. J. Ophth. 21:1019-1024 ( (Sept.) ) 1938. 7. Shemeley, W. G., Jr. Paredrine Hydrobromide for Cycloplegia , Eye, Ear, Nose & Throat Monthly 18:279-282 ( (Oct.) ) 1939. 8. Weinman, E. B., and Fralick, F. B.: Comparative Study of Benzedrine, Paredrine and Cocaine with Homatropine as Cycloplegics , Am. J. Ophth. 23:172-178 ( (Feb.) ) 1940. 9. Tassman, I. S.: The Clinical Uses of Paredrine Hydrobromide in the Eye , Pennsylvania M. J. 44:191-194 ( (Nov.) ) 1940. 10. Thorne, F. H., and Murphy, H. S.: Cycloplegics , Arch. Ophth. 22:274-287 ( (Aug.) ) 1939. 11. (a) Abbott, W. O., and Henry, C. M.: Paredrine: A Clinical Investigation of a Sympathomimetic Drug , Am. J. M. Sc. 193:661-672 ( (May) ) 1937. 12. (b) Mayer, L. L.: Dilation of the Pupil for Ophthalmoscopic Examination , J. A. M. A. 113:38-39 ( (July 1) ) 1939. 13. (c) Laval, J.: Allergic Dermatitis and Conjunctivitis from Paredrine Hydrobromide , Arch. Ophth. 26:585-586 ( (Oct.) ) 1941. 14. Paredrine hydrobromide ophthalmic was used: paredrine hydrobromide 1 per cent in distilled water made tear isotonic with 2 per cent boric acid and preserved with merthiolate 1: 50,000. 15. The method used for the measurement of the residual accommodation was suggested by Dr. Elek Ludvigh II, of the Massachusetts Eye and Ear Infirmary. The patient was made emmetropic for distance with the necessary lenses. Jaeger 1 print was placed 50 cm. from the eye if the vision was 20/20, and a + 3 D. sphere was added to the emmetropic correction. The plus sphere was then decreased 0.25 D. at a time until the print could be made out. The result was usually found to be + 2 D. over the distance correction, and this amount of lense corresponded to the far point in terms of dioptric strength. Minus spheres were now added until the Jaeger print could not be made out. This was the near point. The difference between the far and the near point as expressed in diopters was the amount of residual accommodation. In this manner no movement of the printed matter was necessary. The size of the Jaeger print used depended on the amount of vision present in the eye when it was tested for distance. 16. Marron, J.: Cycloplegia and Mydriasis by Use of Atropine, Scopolamine and Homatropine-Paredrine , Arch. Ophth. 23:340-350 ( (Feb.) ) 1940. 17. Alvaro, M. E.: New Method of Producing Cycloplegia in Refraction , Bol. Soc. de med. e cir. de São Paulo 23:46-51 ( (Feb.) ) 1939. 18. Powell, L. S., and Hyde, M. E.: The Practical Use of Homatropine-Paredrine Cycloplegia , J. Kansas M. Soc. 40:251-254 ( (June) ) 1939. 19. Hartshorne, I.: The Art of Refraction , Eye, Ear, Nose & Throat Monthly 19:201-206 ( (Aug.) ) 1940. 20. Shemeley.5 Weinman.6 Tassman.7

Journal

Archives of Ophthalmology – American Medical Association

Published: Jul 1, 1943

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