Access the full text.
Sign up today, get DeepDyve free for 14 days.
G. Smelser (1936)
Experimental Production of Exophthalmos Resembling that Found in Graves DiseaseProceedings of the Society for Experimental Biology and Medicine, 35
D. Marine, S. Rosen (1933)
Exophthalmos in Thyroidectomized Guinea Pigs by Thyrotropic Substance of Anterior Pituitary, and the Mechanism InvolvedProceedings of the Society for Experimental Biology and Medicine, 30
H. Naffziger, O. Jones (1932)
THE SURGICAL TREATMENT OF PROGRESSIVE EXOPHTHALMOS FOLLOWING THYROIDECTOMYJAMA, 99
H. Moon (1937)
Preparation and Biological Assay of Adrenocorticotropic HormoneProceedings of the Society for Experimental Biology and Medicine, 35
H. C. Naffziger (1933)
Pathologic Changes in the Orbit in Progressive ExophthalmosArch. Ophth., 9
E. Gley (1910)
De l'exophthalmie cons�cutive � la thyroidectomieCompt. rend. Soc. de biol., 68
H. Naffziger (1931)
PROGRESSIVE EXOPHTHALMOS FOLLOWING THYROIDECTOMY; ITS PATHOLOGY AND TREATMENT.Annals of surgery, 94 4
D. Ingle (1936)
WORK CAPACITY OF THE ADRENALECTOMIZED RAT TREATED WITH CORTINAmerican Journal of Physiology, 116
D. Paulson (1939)
Experimental exophthalmos and muscle degeneration induced by thyrotropic hormone., 14
D. Paulson (1937)
Experimental Exophthalmos in the Guinea PigProceedings of the Society for Experimental Biology and Medicine, 36
H. B. Friedgood (1934)
Experimental Exophthalmos and Hyperthyroidism in Guinea PigsBull. Johns Hopkins Hosp., 54
F. E. Burch (1929)
The Exophthalmos of Graves DiseaseMinnesota Med., 12
L. Loeb, H. Friedman (1932)
Exophthalmos Produced by Injections of Acid Extract of Anterior Pituitary Gland of CattleProceedings of the Society for Experimental Biology and Medicine, 29
H. Naffziger (1938)
PROGRESSVE EXOPHTHALMOS ASSOCIATED WITH DISORDERS OF THE THYROID GLANDAnnals of Surgery, 108
J. Schockaert (1931)
Hyperplasia of Thyroid and Exophthalmos from Treatment with Anterior Pituitary in Young Duck. 20Proceedings of the Society for Experimental Biology and Medicine, 29
W. Benedict, H. Wagener (1933)
Pathologic Changes in the Orbit in Progressive ExophthalmosThe American Journal of the Medical Sciences, 185
R. Moore (1920)
A NOTE ON THE EXOPHTHALMOS AND LIMITATION OF THE EYE MOVEMENTS OF GRAVES'S DISEASE.The Lancet, 196
S. Tipton (1938)
THE EFFECT OF CORTIN ON THE ELECTROLYTE CHANGES IN CAT MUSCLE DURING STIMULATION AND RECOVERYAmerican Journal of Physiology, 124
Abstract A study of malignant exophthalmos has been carried on in this clinic for several years.1 In addition to the clinical studies, considerable experimental work has been done, the results of which are reported here. A historical review of the older research and theories on exophthalmos has been presented in detail previously1 and need not be repeated. The term malignant exophthalmos is used to designate the progressive proptosis which, in a small group, increases to an alarming extent. It usually occurs after thyroidectomy in the presence of a low basal metabolic rate, and unless it is relieved by operative decompression of the bony orbit, as devised by Naffziger,1 corneal ulceration, infection and fatal intracranial extension of the orbital cellulitis will develop in a high percentage of the patients. The pathologic changes and immediate cause of the exophthalmos occurring in these patients were described in detail in previous reports. References 1. (a) Naffziger, H. C.: Progressive Exophthalmos Following Thyroidectomy: Its Pathology and Treatment , Ann. Surg. 94:582-586 ( (Oct.) ) 1931.Crossref 2. (b) Naffziger, H. C., and Jones, O. W., Jr.: The Surgical Treatment of Progressive Exophthalmos Following Thyroidectomy , J. A. M. A. 99:638-642 ( (Aug. 20) ) 1932.Crossref 3. (c) Naffziger, H. C.: Pathologic Changes in the Orbit in Progressive Exophthalmos , Arch. Ophth. 9:1-11 ( (Jan.) ) 1933 4. (d) Progressive Exophthalmos Associated with Disorders of the Thyroid Gland , Ann. Surg. 108:529-544 ( (Oct.) ) 1938.Crossref 5. Schockaert, J. A.: Hyperplasia of Thyroid and Exophthalmos from Treatment with Anterior Pituitary in Young Ducks, abstracted, Proc. Soc. Exper. Biol. & Med. 29:306-308 ( (Dec.) ) 1931. 6. Loeb, L., and Friedman, H.: Exophthalmos Produced by Injections of Acid Extract of Anterior Pituitary Gland of Cattle , Proc. Soc. Exper. Biol. & Med. 29:648-650 ( (Feb.) ) 1932. 7. Marine, D., and Rosen, S. H.: Exophthalmos in Thyroidectomized Guinea Pigs by Thyrotropic Substance of Anterior Pituitary and the Mechanism Involved , Proc. Soc. Exper. Biol. & Med. 30:901-903 ( (April) ) 1933. 8. Friedgood, H. B.: Experimental Exophthalmos and Hyperthyroidism in Guinea Pigs , Bull. Johns Hopkins Hosp. 54:48-74 ( (Jan.) ) 1934. 9. Smelser, G. K.: Experimental Production of Exophthalmos Resembling That Found in Graves' Disease , Proc. Soc. Exper. Biol. & Med. 35:128-130 ( (Oct.) ) 1936. 10. Paulson, D. L.: Experimental Exophthalmos in the Guinea Pig , Proc. Soc. Exper. Biol. & Med. 36:604-605 ( (June) ) 1937. 11. Paulson, D. L.: Experimental Exophthalmos and Muscle Degeneration Induced by Thyrotropic Hormone , Proc. Staff Meet., Mayo Clin. 14:828-832 ( (Dec. 27) ) 1939. 12. The extracts used in these two experiments were supplied by Parke, Davis & Company and E. R. Squibb & Sons. 13. Drs. Uyei, Moon and Evans, of the department of experimental biology of the University of California, cooperated in the preparation of these extracts. 14. Gley, E.: De l'exophthalmie consécutive à la thyroidectomie; présentation d'animaux , Compt. rend. Soc. de biol. 68:858-862, 1910. 15. (a) Ingle, D. J.: Work Capacity of the Adrenalectomized Rat Treated with Cortin , Am. J. Physiol. 116:622-625 ( (Aug.) ) 1936. 16. (b) Tipton, S. R.: The Effect of Cortin on the Electrolyte Changes in Cat Muscle During Stimulation and Recovery , Am. J. Physiol. 124:322-327 ( (Nov.) ) 1938. 17. Moon, H. D.: Preparation and Biological Assay of Adrenocorticotropic Hormone , Proc. Soc. Exper. Biol. & Med. 35:649-652 ( (Jan.) ) 1937. 18. Paulson (footnotes 7 and 8). 19. (a) Moore, R. F.: A Note on the Exophthalmos and Limitations of the Eye Movements of Graves's Disease , Lancet 2:701 ( (Oct. 2) ) 1920. 20. (b) Burch, F. E.: The Exophthalmos of Graves Disease , Minnesota Med. 12:668-675 ( (Nov.) ) 1929.
Archives of Ophthalmology – American Medical Association
Published: Dec 1, 1940
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.