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EXPERIMENTAL EXOPHTHALMOS AND ASSOCIATED MYOPATHY INDUCED BY THE THYROTROPIC EXTRACT

EXPERIMENTAL EXOPHTHALMOS AND ASSOCIATED MYOPATHY INDUCED BY THE THYROTROPIC EXTRACT Abstract A study of malignant exophthalmos has been carried on in this clinic for several years.1 In addition to the clinical studies, considerable experimental work has been done, the results of which are reported here. A historical review of the older research and theories on exophthalmos has been presented in detail previously1 and need not be repeated. The term malignant exophthalmos is used to designate the progressive proptosis which, in a small group, increases to an alarming extent. It usually occurs after thyroidectomy in the presence of a low basal metabolic rate, and unless it is relieved by operative decompression of the bony orbit, as devised by Naffziger,1 corneal ulceration, infection and fatal intracranial extension of the orbital cellulitis will develop in a high percentage of the patients. The pathologic changes and immediate cause of the exophthalmos occurring in these patients were described in detail in previous reports. References 1. (a) Naffziger, H. C.: Progressive Exophthalmos Following Thyroidectomy: Its Pathology and Treatment , Ann. Surg. 94:582-586 ( (Oct.) ) 1931.Crossref 2. (b) Naffziger, H. C., and Jones, O. W., Jr.: The Surgical Treatment of Progressive Exophthalmos Following Thyroidectomy , J. A. M. A. 99:638-642 ( (Aug. 20) ) 1932.Crossref 3. (c) Naffziger, H. C.: Pathologic Changes in the Orbit in Progressive Exophthalmos , Arch. Ophth. 9:1-11 ( (Jan.) ) 1933 4. (d) Progressive Exophthalmos Associated with Disorders of the Thyroid Gland , Ann. Surg. 108:529-544 ( (Oct.) ) 1938.Crossref 5. Schockaert, J. A.: Hyperplasia of Thyroid and Exophthalmos from Treatment with Anterior Pituitary in Young Ducks, abstracted, Proc. Soc. Exper. Biol. & Med. 29:306-308 ( (Dec.) ) 1931. 6. Loeb, L., and Friedman, H.: Exophthalmos Produced by Injections of Acid Extract of Anterior Pituitary Gland of Cattle , Proc. Soc. Exper. Biol. & Med. 29:648-650 ( (Feb.) ) 1932. 7. Marine, D., and Rosen, S. H.: Exophthalmos in Thyroidectomized Guinea Pigs by Thyrotropic Substance of Anterior Pituitary and the Mechanism Involved , Proc. Soc. Exper. Biol. & Med. 30:901-903 ( (April) ) 1933. 8. Friedgood, H. B.: Experimental Exophthalmos and Hyperthyroidism in Guinea Pigs , Bull. Johns Hopkins Hosp. 54:48-74 ( (Jan.) ) 1934. 9. Smelser, G. K.: Experimental Production of Exophthalmos Resembling That Found in Graves' Disease , Proc. Soc. Exper. Biol. & Med. 35:128-130 ( (Oct.) ) 1936. 10. Paulson, D. L.: Experimental Exophthalmos in the Guinea Pig , Proc. Soc. Exper. Biol. & Med. 36:604-605 ( (June) ) 1937. 11. Paulson, D. L.: Experimental Exophthalmos and Muscle Degeneration Induced by Thyrotropic Hormone , Proc. Staff Meet., Mayo Clin. 14:828-832 ( (Dec. 27) ) 1939. 12. The extracts used in these two experiments were supplied by Parke, Davis & Company and E. R. Squibb & Sons. 13. Drs. Uyei, Moon and Evans, of the department of experimental biology of the University of California, cooperated in the preparation of these extracts. 14. Gley, E.: De l'exophthalmie consécutive à la thyroidectomie; présentation d'animaux , Compt. rend. Soc. de biol. 68:858-862, 1910. 15. (a) Ingle, D. J.: Work Capacity of the Adrenalectomized Rat Treated with Cortin , Am. J. Physiol. 116:622-625 ( (Aug.) ) 1936. 16. (b) Tipton, S. R.: The Effect of Cortin on the Electrolyte Changes in Cat Muscle During Stimulation and Recovery , Am. J. Physiol. 124:322-327 ( (Nov.) ) 1938. 17. Moon, H. D.: Preparation and Biological Assay of Adrenocorticotropic Hormone , Proc. Soc. Exper. Biol. & Med. 35:649-652 ( (Jan.) ) 1937. 18. Paulson (footnotes 7 and 8). 19. (a) Moore, R. F.: A Note on the Exophthalmos and Limitations of the Eye Movements of Graves's Disease , Lancet 2:701 ( (Oct. 2) ) 1920. 20. (b) Burch, F. E.: The Exophthalmos of Graves Disease , Minnesota Med. 12:668-675 ( (Nov.) ) 1929. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

EXPERIMENTAL EXOPHTHALMOS AND ASSOCIATED MYOPATHY INDUCED BY THE THYROTROPIC EXTRACT

Archives of Ophthalmology , Volume 24 (6) – Dec 1, 1940

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References (18)

Publisher
American Medical Association
Copyright
Copyright © 1940 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1940.00870060109007
Publisher site
See Article on Publisher Site

Abstract

Abstract A study of malignant exophthalmos has been carried on in this clinic for several years.1 In addition to the clinical studies, considerable experimental work has been done, the results of which are reported here. A historical review of the older research and theories on exophthalmos has been presented in detail previously1 and need not be repeated. The term malignant exophthalmos is used to designate the progressive proptosis which, in a small group, increases to an alarming extent. It usually occurs after thyroidectomy in the presence of a low basal metabolic rate, and unless it is relieved by operative decompression of the bony orbit, as devised by Naffziger,1 corneal ulceration, infection and fatal intracranial extension of the orbital cellulitis will develop in a high percentage of the patients. The pathologic changes and immediate cause of the exophthalmos occurring in these patients were described in detail in previous reports. References 1. (a) Naffziger, H. C.: Progressive Exophthalmos Following Thyroidectomy: Its Pathology and Treatment , Ann. Surg. 94:582-586 ( (Oct.) ) 1931.Crossref 2. (b) Naffziger, H. C., and Jones, O. W., Jr.: The Surgical Treatment of Progressive Exophthalmos Following Thyroidectomy , J. A. M. A. 99:638-642 ( (Aug. 20) ) 1932.Crossref 3. (c) Naffziger, H. C.: Pathologic Changes in the Orbit in Progressive Exophthalmos , Arch. Ophth. 9:1-11 ( (Jan.) ) 1933 4. (d) Progressive Exophthalmos Associated with Disorders of the Thyroid Gland , Ann. Surg. 108:529-544 ( (Oct.) ) 1938.Crossref 5. Schockaert, J. A.: Hyperplasia of Thyroid and Exophthalmos from Treatment with Anterior Pituitary in Young Ducks, abstracted, Proc. Soc. Exper. Biol. & Med. 29:306-308 ( (Dec.) ) 1931. 6. Loeb, L., and Friedman, H.: Exophthalmos Produced by Injections of Acid Extract of Anterior Pituitary Gland of Cattle , Proc. Soc. Exper. Biol. & Med. 29:648-650 ( (Feb.) ) 1932. 7. Marine, D., and Rosen, S. H.: Exophthalmos in Thyroidectomized Guinea Pigs by Thyrotropic Substance of Anterior Pituitary and the Mechanism Involved , Proc. Soc. Exper. Biol. & Med. 30:901-903 ( (April) ) 1933. 8. Friedgood, H. B.: Experimental Exophthalmos and Hyperthyroidism in Guinea Pigs , Bull. Johns Hopkins Hosp. 54:48-74 ( (Jan.) ) 1934. 9. Smelser, G. K.: Experimental Production of Exophthalmos Resembling That Found in Graves' Disease , Proc. Soc. Exper. Biol. & Med. 35:128-130 ( (Oct.) ) 1936. 10. Paulson, D. L.: Experimental Exophthalmos in the Guinea Pig , Proc. Soc. Exper. Biol. & Med. 36:604-605 ( (June) ) 1937. 11. Paulson, D. L.: Experimental Exophthalmos and Muscle Degeneration Induced by Thyrotropic Hormone , Proc. Staff Meet., Mayo Clin. 14:828-832 ( (Dec. 27) ) 1939. 12. The extracts used in these two experiments were supplied by Parke, Davis & Company and E. R. Squibb & Sons. 13. Drs. Uyei, Moon and Evans, of the department of experimental biology of the University of California, cooperated in the preparation of these extracts. 14. Gley, E.: De l'exophthalmie consécutive à la thyroidectomie; présentation d'animaux , Compt. rend. Soc. de biol. 68:858-862, 1910. 15. (a) Ingle, D. J.: Work Capacity of the Adrenalectomized Rat Treated with Cortin , Am. J. Physiol. 116:622-625 ( (Aug.) ) 1936. 16. (b) Tipton, S. R.: The Effect of Cortin on the Electrolyte Changes in Cat Muscle During Stimulation and Recovery , Am. J. Physiol. 124:322-327 ( (Nov.) ) 1938. 17. Moon, H. D.: Preparation and Biological Assay of Adrenocorticotropic Hormone , Proc. Soc. Exper. Biol. & Med. 35:649-652 ( (Jan.) ) 1937. 18. Paulson (footnotes 7 and 8). 19. (a) Moore, R. F.: A Note on the Exophthalmos and Limitations of the Eye Movements of Graves's Disease , Lancet 2:701 ( (Oct. 2) ) 1920. 20. (b) Burch, F. E.: The Exophthalmos of Graves Disease , Minnesota Med. 12:668-675 ( (Nov.) ) 1929.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Dec 1, 1940

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