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Endothelial Changes Associated With Topical Dorzolamide Do Appear toBe Significant—Reply

Endothelial Changes Associated With Topical Dorzolamide Do Appear toBe Significant—Reply In reply We thank Epstein and colleagues for their valuable comment. As we showedin our study, there was a statistically significant thickening in centralcorneal thickness in patients with low endothelial cell counts after a 24-hourapplication of dorzolamide hydrochloride. However, the corneal thickeningof 12 µm is probably not clinically relevant. We agree that with prolongeddorzolamide treatment, the cornea may show a further increase in thickness.On the other hand, as we mentioned in the "Comment" section of our article,it is also possible that the corneal thickness would not increase any furtheror possibly even return to baseline thickness as a result of counterregulatoryprocesses on the cellular level. We simply cannot say from our data. To answerthis question, we are currently carrying out a trial with a similar studydesign but with long-term application of dorzolamide in patients with a lowendothelial cell count. Correspondence: Dr Findl, Department of Ophthalmology, Universityof Vienna, Wahringer Gurtel 18-20, Vienna 1090, Austria (oliver.findl@akh.wien.ac.at). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Endothelial Changes Associated With Topical Dorzolamide Do Appear toBe Significant—Reply

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Publisher
American Medical Association
Copyright
Copyright © 2004 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.122.7.1090-a
Publisher site
See Article on Publisher Site

Abstract

In reply We thank Epstein and colleagues for their valuable comment. As we showedin our study, there was a statistically significant thickening in centralcorneal thickness in patients with low endothelial cell counts after a 24-hourapplication of dorzolamide hydrochloride. However, the corneal thickeningof 12 µm is probably not clinically relevant. We agree that with prolongeddorzolamide treatment, the cornea may show a further increase in thickness.On the other hand, as we mentioned in the "Comment" section of our article,it is also possible that the corneal thickness would not increase any furtheror possibly even return to baseline thickness as a result of counterregulatoryprocesses on the cellular level. We simply cannot say from our data. To answerthis question, we are currently carrying out a trial with a similar studydesign but with long-term application of dorzolamide in patients with a lowendothelial cell count. Correspondence: Dr Findl, Department of Ophthalmology, Universityof Vienna, Wahringer Gurtel 18-20, Vienna 1090, Austria (oliver.findl@akh.wien.ac.at).

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Jul 1, 2004

Keywords: endothelium,dorzolamide

There are no references for this article.