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Comparison of Psychological Effects of Certain Centrally Acting Drugs in Man

Comparison of Psychological Effects of Certain Centrally Acting Drugs in Man Abstract A number of recent studies have emphasized that the psychological effects of a given drug are not entirely a function of the drug's more classic "pharmacological properties." On the contrary, as pointed out by Lasagna et al., "the nature of the subject and the situation in which a drug is administered are important determinants of drug effects."1 The point of view which Lasagna has presented is supported by the results of Hill et al.2 and of Kornetsky.3 These investigators have demonstrated that an informal, friendly attitude by the experimenter toward the subject affects the analgesic effect of morphine, and that reaction time is not decreased when subjects are motivated by electric shock.4 Von Felsinger et al.5 have concluded that those subjects who respond atypically to one drug are likely to respond atypically to other drugs. The present studies have been designed to obtain further data References 1. Lasagna, L.; von Felsinger, J. M., and Beecher, H. K.: Drug-Induced Mood Changes in Man: 1. Observations on Healthy Subjects, Chronically Ill Patients, and "Postaddicts," J. A. M. A. 157:1006-1020, 1955.Crossref 2. Hill, H.; Kornetsky, C.; Flanary, H., and Wikler, A.: Effects of Anxiety and Morphine on Discrimination of Intensities of Painful Stimuli , J. Clin. Invest. 31:473-480, 1952.Crossref 3. Kornetsky, C.: Effects of Anxiety and Morphine on the Anticipation and Perception of Painful Radiant Thermal Stimuli , J. Comp. & Physiol. Psychol. 47:130-132, 1954. 4. Hill, H.; Kornetsky, C.; Flanary, H., and Wikler, A.: Studies on Anxiety Associated with Anticipation of Pain: I. Effects of Morphine , A. M. A. Arch. Neurol. & Psychiat. 67:612-619, 1952. 5. von Felsinger, J. M.; Lasagna, L., and Beecher, H. K.: Drug-Induced Mood Changes in Man: 2. Personality and Reactions to Drugs , J.A.M.A. 157:1113-1119, 1955. 6. Birren, J. E.; Allen, W. R., and Landau, H. G.: Relation of Problem Length in Simple Addition to Time Required, Probability of Success, and Age , J. Gerontol. 9:150-161, 1954. 7. Wechsler, D.: The Measurement of Adult Intelligence , Ed. 3, Baltimore, Williams & Wilkins Company, 1944, p. 185. 8. Kornetsky, C.: Psychological Effects of Chronic Barbiturate Intoxication , A. M. A. Arch. Neurol. & Psychiat. 65:557-567, 1951, p. 559. 9. Birren, J. E., and Botwinick, J.: The Relation of Writing Speed to Age and to the Senile Psychosis , J. Consult. Psychol. 15:243-249, 1951. 10. Semmes, J.; Weinstein, S.; Ghent, L., and Teuber, H. L.: Changes in Somatic Sensation After Penetrating Brain Wounds in Man, in preparation. 11. Abramson, H. A.; Jarvik, M. E.; Kaufman, M. R.; Kornetsky, C.; Levine, A., and Wagner, M. J.: Lysergic Acid Diethylamide (LSD-25): I. Physiological and Perceptual Response , J. Psychol. 39:3-60, 1955. 12. Edwards, A. L.: Statistical Analysis for Students in Psychology and Education , New York, Rinehart & Company, Inc., 1946, p. 217. 13. Edwards,12 p. 123. 14. Dunnett, C. W.: A Multiple Comparison Procedure for Comparing Several Treatments with a Control , J. Am. Statist. A. 50:1096-1121, 1955. 15. Scheffé, H.: A Method for Judging All Contrasts in the Analysis of Variance , Biometrika 40:87-104, 1953. 16. Abramson, H. A.; Jarvik, M. E., and Hirsch, M. W.: Lysergic Acid Diethylamide (LSD-25): VII. Effect upon Two Measures of Motor Performance , J. Psychol. 39:455-464, 1955. 17. Jarvik, M. E.; Abramson, H. A., and Hirsch, M. W.: Lysergic Acid Diethylamide (LSD-25): IV. Effect on Attention and Concentration , J. Psychol. 39:373-383, 1955. 18. Landis, C., and Clausen, J.: Certain Effects of Mescaline and Lysergic Acid Diethylamide on Psychological Functions , J. Psychol. 38:211-221, 1954. 19. Arkola, A. L.: An Experimental Study of the Effects of Sodium Amytal upon Performance on the Hunt-Minnesota Test for Organic Brain Damage , J. Clin. Psychol. 3:392-396, 1947. 20. Slater, P., and Sargant, W.: Influence of Sodium Amytal on Intelligence-Test Scores , Lancet 242:676-677, 1942. 21. Hill, H. E., and Belleville, R. E.: Effects of Chronic Barbiturate Intoxication on Motivation and Muscular Coordination , A. M. A. Arch. Neurol. & Psychiat. 70:180-188, 1953. 22. Ideström, C.: Flicker-Fusion in Chronic Barbiturate Usage: A Quantitative Study in the Pathophysiology of Drug Addiction , Acta psychiat. et neurol. 91:1-73, 1954. 23. Lehmann, H. E., and Hanrahan, G. E.: Chlorpromazine: New Inhibiting Agent for Psychomotor Excitement and Manic States , A. M. A. Arch. Neurol. & Psychiat. 71:227-237, 1954. 24. Kendall, M. G.: Rank Correlation Methods , London, Charles Griffin & Co., Ltd., 1948, p. 80. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Neurology & Psychiatry American Medical Association

Comparison of Psychological Effects of Certain Centrally Acting Drugs in Man

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References (28)

Publisher
American Medical Association
Copyright
Copyright © 1957 American Medical Association. All Rights Reserved.
ISSN
0096-6886
DOI
10.1001/archneurpsyc.1957.02330330104016
Publisher site
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Abstract

Abstract A number of recent studies have emphasized that the psychological effects of a given drug are not entirely a function of the drug's more classic "pharmacological properties." On the contrary, as pointed out by Lasagna et al., "the nature of the subject and the situation in which a drug is administered are important determinants of drug effects."1 The point of view which Lasagna has presented is supported by the results of Hill et al.2 and of Kornetsky.3 These investigators have demonstrated that an informal, friendly attitude by the experimenter toward the subject affects the analgesic effect of morphine, and that reaction time is not decreased when subjects are motivated by electric shock.4 Von Felsinger et al.5 have concluded that those subjects who respond atypically to one drug are likely to respond atypically to other drugs. The present studies have been designed to obtain further data References 1. Lasagna, L.; von Felsinger, J. M., and Beecher, H. K.: Drug-Induced Mood Changes in Man: 1. Observations on Healthy Subjects, Chronically Ill Patients, and "Postaddicts," J. A. M. A. 157:1006-1020, 1955.Crossref 2. Hill, H.; Kornetsky, C.; Flanary, H., and Wikler, A.: Effects of Anxiety and Morphine on Discrimination of Intensities of Painful Stimuli , J. Clin. Invest. 31:473-480, 1952.Crossref 3. Kornetsky, C.: Effects of Anxiety and Morphine on the Anticipation and Perception of Painful Radiant Thermal Stimuli , J. Comp. & Physiol. Psychol. 47:130-132, 1954. 4. Hill, H.; Kornetsky, C.; Flanary, H., and Wikler, A.: Studies on Anxiety Associated with Anticipation of Pain: I. Effects of Morphine , A. M. A. Arch. Neurol. & Psychiat. 67:612-619, 1952. 5. von Felsinger, J. M.; Lasagna, L., and Beecher, H. K.: Drug-Induced Mood Changes in Man: 2. Personality and Reactions to Drugs , J.A.M.A. 157:1113-1119, 1955. 6. Birren, J. E.; Allen, W. R., and Landau, H. G.: Relation of Problem Length in Simple Addition to Time Required, Probability of Success, and Age , J. Gerontol. 9:150-161, 1954. 7. Wechsler, D.: The Measurement of Adult Intelligence , Ed. 3, Baltimore, Williams & Wilkins Company, 1944, p. 185. 8. Kornetsky, C.: Psychological Effects of Chronic Barbiturate Intoxication , A. M. A. Arch. Neurol. & Psychiat. 65:557-567, 1951, p. 559. 9. Birren, J. E., and Botwinick, J.: The Relation of Writing Speed to Age and to the Senile Psychosis , J. Consult. Psychol. 15:243-249, 1951. 10. Semmes, J.; Weinstein, S.; Ghent, L., and Teuber, H. L.: Changes in Somatic Sensation After Penetrating Brain Wounds in Man, in preparation. 11. Abramson, H. A.; Jarvik, M. E.; Kaufman, M. R.; Kornetsky, C.; Levine, A., and Wagner, M. J.: Lysergic Acid Diethylamide (LSD-25): I. Physiological and Perceptual Response , J. Psychol. 39:3-60, 1955. 12. Edwards, A. L.: Statistical Analysis for Students in Psychology and Education , New York, Rinehart & Company, Inc., 1946, p. 217. 13. Edwards,12 p. 123. 14. Dunnett, C. W.: A Multiple Comparison Procedure for Comparing Several Treatments with a Control , J. Am. Statist. A. 50:1096-1121, 1955. 15. Scheffé, H.: A Method for Judging All Contrasts in the Analysis of Variance , Biometrika 40:87-104, 1953. 16. Abramson, H. A.; Jarvik, M. E., and Hirsch, M. W.: Lysergic Acid Diethylamide (LSD-25): VII. Effect upon Two Measures of Motor Performance , J. Psychol. 39:455-464, 1955. 17. Jarvik, M. E.; Abramson, H. A., and Hirsch, M. W.: Lysergic Acid Diethylamide (LSD-25): IV. Effect on Attention and Concentration , J. Psychol. 39:373-383, 1955. 18. Landis, C., and Clausen, J.: Certain Effects of Mescaline and Lysergic Acid Diethylamide on Psychological Functions , J. Psychol. 38:211-221, 1954. 19. Arkola, A. L.: An Experimental Study of the Effects of Sodium Amytal upon Performance on the Hunt-Minnesota Test for Organic Brain Damage , J. Clin. Psychol. 3:392-396, 1947. 20. Slater, P., and Sargant, W.: Influence of Sodium Amytal on Intelligence-Test Scores , Lancet 242:676-677, 1942. 21. Hill, H. E., and Belleville, R. E.: Effects of Chronic Barbiturate Intoxication on Motivation and Muscular Coordination , A. M. A. Arch. Neurol. & Psychiat. 70:180-188, 1953. 22. Ideström, C.: Flicker-Fusion in Chronic Barbiturate Usage: A Quantitative Study in the Pathophysiology of Drug Addiction , Acta psychiat. et neurol. 91:1-73, 1954. 23. Lehmann, H. E., and Hanrahan, G. E.: Chlorpromazine: New Inhibiting Agent for Psychomotor Excitement and Manic States , A. M. A. Arch. Neurol. & Psychiat. 71:227-237, 1954. 24. Kendall, M. G.: Rank Correlation Methods , London, Charles Griffin & Co., Ltd., 1948, p. 80.

Journal

A.M.A. Archives of Neurology & Psychiatry – American Medical Association

Published: Mar 1, 1957

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