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Combined Reserpine-Chlorpromazine in Treatment of Disturbed Psychotics

Combined Reserpine-Chlorpromazine in Treatment of Disturbed Psychotics Abstract Great interest has recently been centered on two new drugs for the treatment of mental disorders, chlorpromazine and reserpine. The former, a synthetic, was used in Europe for several years before it was finally introduced into this country. Reserpine is a crystalline alkaloid extracted from the root of the plant Rauwolfia serpentina Benth. This plant was used for centuries in India for the treatment of a wide variety of diseases, including mental disorders. It was introduced into this country for its use in the management of hypertension. In 1952, Müller, Schlittler, and Bein1 identified reserpine, which appeared to be the chief active principle of Rauwolfia. We have reported elsewhere * our experiences with reserpine alone in the treatment of disturbed psychotics. Chlorpromazine also has the property of potentiating the effects of hypnotics and sedatives. Because of this, we decided to investigate the effect of combining reserpine and chlorpromazine. At first References 1. References 2 to 9. 2. References 3, 4, and 5. 3. Müller, J. M.; Schlittler, E., and Bein, H. J.: Reserpin, der sedative Wirkstoff aus Rauwolfia serpentina Benth. , Experientia 8:338, 1952.Crossref 4. Kline, N. S.: Use of Rauwolfia Serpentina Benth. in Neuropsychiatric Conditions , Ann. New York Acad. Sc. 59:107, 1954.Crossref 5. Barsa, J. A., and Kline, N. S.: Use of Reserpine in Disturbed Psychotic Patients , Am. J. Psychiat. , to be published. 6. Barsa, J. A., and Kline, N. S.: Treatment of 200 Disturbed Psychotics with Reserpine , J. A. M. A. 158:110, 1955.Crossref 7. Barsa, J. A., and Kline, N. S.: Reserpine in the Treatment of Psychotics with Convulsive Disorders , A. M. A. Arch. Neurol. & Psychiat. 74: 31, 1955. 8. Gosline, E., and Kline, N. S.: Use of Reserpine on an Admission Service, Report , American Psychiatric Association, Regional Research Conference, Galveston, Texas, to be published. 9. Nicolaou, G., and Kline, N. S.: Reserpine in Disturbed Adolescents, Report , American Psychiatric Asssociation, Regional Research Conference, Galveston, Texas, to be published. 10. Kline, N. S., and Stanley, A. M.: Use of Reserpine in a Neuropsychiatric Hospital , Ann. New York Acad. Sc. 61:85, 1955. 11. Kline, N. S.: Psychiatry-Pharmacology: Recent Advances , American Association for Advancement of Science, Monograph, to be published. 12. Barsa, J. A., and Kline, N. S.: Combined Reserpine-Chlorpromazine Therapy in Disturbed Psychotics: Preliminary Report , Am. J. Psychiat. 111:780, 1955. 13. Barsa, J. A., and Kline, N. S.: Agranulocytosis While Receiving Combined Reserpine-Chlorpromazine Therapy: Report of 2 Cases , Dis. Nerv. System , to be published. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Neurology & Psychiatry American Medical Association

Combined Reserpine-Chlorpromazine in Treatment of Disturbed Psychotics

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References (14)

Publisher
American Medical Association
Copyright
Copyright © 1955 American Medical Association. All Rights Reserved.
ISSN
0096-6886
DOI
10.1001/archneurpsyc.1955.02330150046006
Publisher site
See Article on Publisher Site

Abstract

Abstract Great interest has recently been centered on two new drugs for the treatment of mental disorders, chlorpromazine and reserpine. The former, a synthetic, was used in Europe for several years before it was finally introduced into this country. Reserpine is a crystalline alkaloid extracted from the root of the plant Rauwolfia serpentina Benth. This plant was used for centuries in India for the treatment of a wide variety of diseases, including mental disorders. It was introduced into this country for its use in the management of hypertension. In 1952, Müller, Schlittler, and Bein1 identified reserpine, which appeared to be the chief active principle of Rauwolfia. We have reported elsewhere * our experiences with reserpine alone in the treatment of disturbed psychotics. Chlorpromazine also has the property of potentiating the effects of hypnotics and sedatives. Because of this, we decided to investigate the effect of combining reserpine and chlorpromazine. At first References 1. References 2 to 9. 2. References 3, 4, and 5. 3. Müller, J. M.; Schlittler, E., and Bein, H. J.: Reserpin, der sedative Wirkstoff aus Rauwolfia serpentina Benth. , Experientia 8:338, 1952.Crossref 4. Kline, N. S.: Use of Rauwolfia Serpentina Benth. in Neuropsychiatric Conditions , Ann. New York Acad. Sc. 59:107, 1954.Crossref 5. Barsa, J. A., and Kline, N. S.: Use of Reserpine in Disturbed Psychotic Patients , Am. J. Psychiat. , to be published. 6. Barsa, J. A., and Kline, N. S.: Treatment of 200 Disturbed Psychotics with Reserpine , J. A. M. A. 158:110, 1955.Crossref 7. Barsa, J. A., and Kline, N. S.: Reserpine in the Treatment of Psychotics with Convulsive Disorders , A. M. A. Arch. Neurol. & Psychiat. 74: 31, 1955. 8. Gosline, E., and Kline, N. S.: Use of Reserpine on an Admission Service, Report , American Psychiatric Association, Regional Research Conference, Galveston, Texas, to be published. 9. Nicolaou, G., and Kline, N. S.: Reserpine in Disturbed Adolescents, Report , American Psychiatric Asssociation, Regional Research Conference, Galveston, Texas, to be published. 10. Kline, N. S., and Stanley, A. M.: Use of Reserpine in a Neuropsychiatric Hospital , Ann. New York Acad. Sc. 61:85, 1955. 11. Kline, N. S.: Psychiatry-Pharmacology: Recent Advances , American Association for Advancement of Science, Monograph, to be published. 12. Barsa, J. A., and Kline, N. S.: Combined Reserpine-Chlorpromazine Therapy in Disturbed Psychotics: Preliminary Report , Am. J. Psychiat. 111:780, 1955. 13. Barsa, J. A., and Kline, N. S.: Agranulocytosis While Receiving Combined Reserpine-Chlorpromazine Therapy: Report of 2 Cases , Dis. Nerv. System , to be published.

Journal

A.M.A. Archives of Neurology & PsychiatryAmerican Medical Association

Published: Sep 1, 1955

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