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ANTICONVULSANT ACTIVITIES OF CERTAIN THIAZOLIDONES AND HYDANTOINS AS DETERMINED BY ELECTRIC SHOCK PROCEDURES IN CATS, RATS AND MICE

ANTICONVULSANT ACTIVITIES OF CERTAIN THIAZOLIDONES AND HYDANTOINS AS DETERMINED BY ELECTRIC SHOCK... Abstract IN ANOTHER paper,1 a comparison is made of the anticonvulsant activities of antiepileptic drugs by two electric shock methods. The order of potency of these compounds was found to be the same when tested by the procedure of Putnam and Merritt2 in the cat and by that of Toman, Swinyard and Goodman3 in the mouse. In the rat, the latter procedure gave some compounds a relative potency different from that in the other two species of animals. In this paper, there will be presented from the standpoint of chemical structure and pharmacologic action the anticonvulsant activities of three series of compounds: (a) 2-phenyl-3-alkyl-4-thiazolidones and their dioxides, (b) l-alkyl-5-thienylhydantoins and (c) 5,5-di-aryl-hydantoins. The results were obtained with the two electric shock procedures in cats, rats and mice. These, and the data for some miscellaneous compounds, are analyzed to show the specificity of the two methods and the species References 1. Chen, G., and Ensor, C. R.: Evaluation of Antiepileptic Drugs , Arch. Neurol. & Psychiat. , to be published. 2. Putnam, T. J., and Merritt, H. H.: Experimental Determination of the Anticonvulsant Properties of Some Phenyl Derivatives , Science 85:525-526, 1937.Crossref 3. Toman, J. E. P.; Swinyard, E. A., and Goodman, L. S.: Properties of Maximal Seizures and Their Alteration by Anticonvulsant Drugs and Other Agents , J. Neurophysiol. 9:231-240, 1946. 4. These compounds were made available to us by Dr. L. M. Long and Mr. W. R. Coleman, Chemical Division, Research Laboratories, Parke, Davis & Company, Detroit. 5. Gruhzit, O. M.: Sodium Diphenyl Hydantoinate: Pharmacologic and Histopathologic Studies , Arch. Path. 28:761 ( (Nov.) ) 1939. 6. Peterman, M. G.: Epilepsy in Childhood , J. A. M. A. 138:1012 ( (Dec. 4) ) 1948.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology & Psychiatry American Medical Association

ANTICONVULSANT ACTIVITIES OF CERTAIN THIAZOLIDONES AND HYDANTOINS AS DETERMINED BY ELECTRIC SHOCK PROCEDURES IN CATS, RATS AND MICE

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References (7)

Publisher
American Medical Association
Copyright
Copyright © 1949 American Medical Association. All Rights Reserved.
ISSN
0096-6754
DOI
10.1001/archneurpsyc.1949.02310180158019
Publisher site
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Abstract

Abstract IN ANOTHER paper,1 a comparison is made of the anticonvulsant activities of antiepileptic drugs by two electric shock methods. The order of potency of these compounds was found to be the same when tested by the procedure of Putnam and Merritt2 in the cat and by that of Toman, Swinyard and Goodman3 in the mouse. In the rat, the latter procedure gave some compounds a relative potency different from that in the other two species of animals. In this paper, there will be presented from the standpoint of chemical structure and pharmacologic action the anticonvulsant activities of three series of compounds: (a) 2-phenyl-3-alkyl-4-thiazolidones and their dioxides, (b) l-alkyl-5-thienylhydantoins and (c) 5,5-di-aryl-hydantoins. The results were obtained with the two electric shock procedures in cats, rats and mice. These, and the data for some miscellaneous compounds, are analyzed to show the specificity of the two methods and the species References 1. Chen, G., and Ensor, C. R.: Evaluation of Antiepileptic Drugs , Arch. Neurol. & Psychiat. , to be published. 2. Putnam, T. J., and Merritt, H. H.: Experimental Determination of the Anticonvulsant Properties of Some Phenyl Derivatives , Science 85:525-526, 1937.Crossref 3. Toman, J. E. P.; Swinyard, E. A., and Goodman, L. S.: Properties of Maximal Seizures and Their Alteration by Anticonvulsant Drugs and Other Agents , J. Neurophysiol. 9:231-240, 1946. 4. These compounds were made available to us by Dr. L. M. Long and Mr. W. R. Coleman, Chemical Division, Research Laboratories, Parke, Davis & Company, Detroit. 5. Gruhzit, O. M.: Sodium Diphenyl Hydantoinate: Pharmacologic and Histopathologic Studies , Arch. Path. 28:761 ( (Nov.) ) 1939. 6. Peterman, M. G.: Epilepsy in Childhood , J. A. M. A. 138:1012 ( (Dec. 4) ) 1948.Crossref

Journal

Archives of Neurology & Psychiatry – American Medical Association

Published: Dec 1, 1949

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