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INTERPRETATION OF FINDINGS IN THE CEREBROSPINAL FLUID: I. THE DEMENTIA PARALYTIGA FORMULA AND THE NECESSITY OF ITS QUANTITATIVE DIFFERENTIATION

INTERPRETATION OF FINDINGS IN THE CEREBROSPINAL FLUID: I. THE DEMENTIA PARALYTIGA FORMULA AND THE... Abstract DEFINITION The term "dementia paralytica formula" will here be reserved for the humoral data alone as encountered in cases of typical, not effectively treated dementia paralytica, the acute forms being disregarded, while "dementia paralytica syndrome" is used for the ensemble of clinical and humoral data. With this restriction, the dementia paralytica formula is fairly uniform. It denotes a clear and colorless aspect of the cerebrospinal fluid and the following results of the obligatory tests.1. In the quantitative analysis of the cell picture higher numbers of mononuclear cells are encountered with dementia paralytica than with other chronic forms of neurosyphilis, say 30 to 100 cells per cubic millimeter. Qualitatively, the peculiar polymorphism of the cells, which invariably include plasma cells, is so striking that previously it was believed to be specific.2. The total protein content also is distinctly higher with dementia paralytica than with other chronic forms of neurosyphilis. References 1. Wadsworth, A.; Maltaner, F., and Maltaner, E.: Quantitative Studies of the Complement-Fixation Reaction with Syphilitic Serum and Tissue Extract: Technic of the Practical Quantitative Test , J. Immunol. 35:217-234, 1938. 2. Lange, C.: Methods for the Examination of Spinal Fluid , Am. J. Syph., Gonor. & Ven. Dis. 23: 638-668, 1939. 3. Lange, C., and Harris, A. H.: The Significance of the pH in the Gold Reaction , J. Lab. & Clin. Med. 29:970-975, 1944. 4. Thompson, L. J.: Interpretation of the "Paretic Curve" in Lange's Colloidal Gold Test , Arch. Neurol. & Psychiat. 5:131-145 ( (Feb.) ) 1921. 5. Lange, C.: Lumbalpunktion und Liquordiagnostik , in Kraus, F., and Brugsch, T.: Spezielle Pathologie und Therapie , Berlin, Urban & Schwarzenberg, 1923, vol. 2, pp. 435-686. 6. Lange, C.: Die Ausflockung kolloidalen Goldes durch Zerebrospinalflüssigkeit bei luetischen Affektionen des Zentralnervensystems , Ztschr. f. Chemotherap. 1: 44-78, 1912. 7. Emanuel, G., and Rosenfeld, H.: Die Emanuelsche Mastixreaction der Rückenmarksflüssigkeit in neuer Form , Klin. Wchnschr. 6:1375-1378, 1927. 8. Lange, C., and Harris, A. H.: A Citrate Gold of Optimal and Reproducible Sensitivity for Use in the Colloidal Gold Reaction: Its Preparation and Control , Am. J. Pub. Health 34:1087-1092, 1944. 9. Stokes, J. H.: Modern Clinical Syphilology , ed. 3, Philadelphia, W. B. Saunders Company, 1944, (a) p. 119; (b) p. 116. 10. Moore, J. E.: The Modern Treatment of Syphilis , ed. 2, Springfield, Ill., Charles C Thomas, Publisher, 1943, p. 368. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology & Psychiatry American Medical Association

INTERPRETATION OF FINDINGS IN THE CEREBROSPINAL FLUID: I. THE DEMENTIA PARALYTIGA FORMULA AND THE NECESSITY OF ITS QUANTITATIVE DIFFERENTIATION

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References (11)

Publisher
American Medical Association
Copyright
Copyright © 1945 American Medical Association. All Rights Reserved.
ISSN
0096-6754
DOI
10.1001/archneurpsyc.1945.02300020028002
Publisher site
See Article on Publisher Site

Abstract

Abstract DEFINITION The term "dementia paralytica formula" will here be reserved for the humoral data alone as encountered in cases of typical, not effectively treated dementia paralytica, the acute forms being disregarded, while "dementia paralytica syndrome" is used for the ensemble of clinical and humoral data. With this restriction, the dementia paralytica formula is fairly uniform. It denotes a clear and colorless aspect of the cerebrospinal fluid and the following results of the obligatory tests.1. In the quantitative analysis of the cell picture higher numbers of mononuclear cells are encountered with dementia paralytica than with other chronic forms of neurosyphilis, say 30 to 100 cells per cubic millimeter. Qualitatively, the peculiar polymorphism of the cells, which invariably include plasma cells, is so striking that previously it was believed to be specific.2. The total protein content also is distinctly higher with dementia paralytica than with other chronic forms of neurosyphilis. References 1. Wadsworth, A.; Maltaner, F., and Maltaner, E.: Quantitative Studies of the Complement-Fixation Reaction with Syphilitic Serum and Tissue Extract: Technic of the Practical Quantitative Test , J. Immunol. 35:217-234, 1938. 2. Lange, C.: Methods for the Examination of Spinal Fluid , Am. J. Syph., Gonor. & Ven. Dis. 23: 638-668, 1939. 3. Lange, C., and Harris, A. H.: The Significance of the pH in the Gold Reaction , J. Lab. & Clin. Med. 29:970-975, 1944. 4. Thompson, L. J.: Interpretation of the "Paretic Curve" in Lange's Colloidal Gold Test , Arch. Neurol. & Psychiat. 5:131-145 ( (Feb.) ) 1921. 5. Lange, C.: Lumbalpunktion und Liquordiagnostik , in Kraus, F., and Brugsch, T.: Spezielle Pathologie und Therapie , Berlin, Urban & Schwarzenberg, 1923, vol. 2, pp. 435-686. 6. Lange, C.: Die Ausflockung kolloidalen Goldes durch Zerebrospinalflüssigkeit bei luetischen Affektionen des Zentralnervensystems , Ztschr. f. Chemotherap. 1: 44-78, 1912. 7. Emanuel, G., and Rosenfeld, H.: Die Emanuelsche Mastixreaction der Rückenmarksflüssigkeit in neuer Form , Klin. Wchnschr. 6:1375-1378, 1927. 8. Lange, C., and Harris, A. H.: A Citrate Gold of Optimal and Reproducible Sensitivity for Use in the Colloidal Gold Reaction: Its Preparation and Control , Am. J. Pub. Health 34:1087-1092, 1944. 9. Stokes, J. H.: Modern Clinical Syphilology , ed. 3, Philadelphia, W. B. Saunders Company, 1944, (a) p. 119; (b) p. 116. 10. Moore, J. E.: The Modern Treatment of Syphilis , ed. 2, Springfield, Ill., Charles C Thomas, Publisher, 1943, p. 368.

Journal

Archives of Neurology & Psychiatry – American Medical Association

Published: Feb 1, 1945

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