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F. Bernheim (1936)
Action of Drugs on Choline Esterase of the BrainJ. Pharmacol. & Exper. Therap., 57
A. M. Fiamberti (1937)
Accessi a carattere epilettico provocati con l'introduzione sottoccipitale di sostanze vasodilatriciRiv. sper. di freniat., 61
B. B. Dikshit (1938)
Acetylcholine Formation by TissuesQuart. J. Exper. Physiol., 28
(1940)
Effects of Eserine, Acetylcholine and Atropine on the ElectrocortigramJ. Neurophysiol., 3
A. Rossi (1939)
Ricerche sperimentali sulle convulsioni da acetilcolinaNote e riv. di psichiat., 68
H. de Wispelaere (1937)
Actions de l'ac�tyl-B-m�thylcholine, etc. sur la circulation et sur la respirationArch. internat. de pharmacodyn. et de thérap., 56
J. Flexner (1939)
Effect of Acetyl-B-Methylcholine (Mecholyl) on Gastric Secretion in Animals and in ManAm. J. Digest. Dis., 5
A. Simonart (1932)
ON THE ACTION OF CERTAIN DERIVATIVES OF CHOLINEJournal of Pharmacology and Experimental Therapeutics, 46
F. R. Miller , G. W. Stavraky (1938)
Effects of Eserine, Acetylcholine and Atropine on the ElectroencephalogramAm. J. Physiol., 123
D. Nachmansohn (1937)
Cholinesterase in Central Nervous SystemNature, 140
H. H. Merritt (1938)
A New Series of Anticonvulsant Drugs Tested by Experiments on AnimalsArch. Neurol. & Psychiat., 39
H. Merritt, T. Putnam (1938)
A NEW SERIES OF ANTICONVULSANT DRUGS TESTED BY EXPERIMENTS ON ANIMALSJournal of Nervous and Mental Disease, 39
B. Dikshit (1938)
ACETYLCHOLINE FORMATION BY TISSUESExperimental Physiology, 28
Denis Williams (1941)
THE EFFECT OF CHOLIN-LIKE SUBSTANCES ON THE CEREBRAL ELECTRICAL DISCHARGES IN EPILEPSYJournal of Neurology and Psychiatry, 4
D. Nachmansohn (1937)
Choline Esterase in the Central Nervous SystemNature, 140
W. Henderson, W. Wilson (1936)
INTRAVENTRICULAR INJECTION OF ACETYLCHOLINE AND ESERINE IN MANExperimental Physiology, 26
E. Stedman (1937)
Occurrence of Acetylcholine in BrainJ. Physiol., 89
W. R. Henderson (1936)
Intraventricular Injection of Acetylcholine and Eserine in ManQuart. J. Exper. Physiol., 26
Abstract The present report deals with the results and interpretation of a series of experiments on the effect of three choline derivatives on the electrical activity of the cerebral cortex of cats. The three compounds tested were acetylcholine chloride, acetylbetamethylcholine chloride (mecholyl chloride) and carbamylcholine chloride (doryl).1 METHOD Adult cats were anesthetized with intraperitoneal injections of dial; both cerebral hemispheres were widely exposed and the dura removed. A total of 57 animals was used. The electrical activity of various cortical areas was recorded with a multichannel Grass electroencephalograph. The stages of amplification in this instrument are condenser coupled, and the recorder writes in ink on a paper tape. This instrument records all frequencies between 2 and 70 per second. Unipolar leads were employed, the stigmatic electrode being formed by a cotton wool wick soaked in physiologic solution of sodium chloride, one end of which rested on the surface of the References 1. These drugs were furnished by Merck & Co., Inc., Rahway, N. J. 2. The prostigmine methylsulfate was furnished by Hoffmann-LaRoche, Inc., Nutley, N. J. 3. Miller, F. R.; Stavraky, G. W., and Woonton, G. A.: Effects of Eserine, Acetylcholine and Atropine on the Electroencephalogram , Am. J. Physiol. 123:147 ( (July) ) 1938 4. Effects of Eserine, Acetylcholine and Atropine on the Electrocortigram , J. Neurophysiol. 3:131-138 ( (March) ) 1940. 5. Bernheim, F., and Bernheim, M. L. C.: Action of Drugs on Choline Esterase of the Brain , J. Pharmacol. & Exper. Therap. 57:427-436 ( (Aug.) ) 1936. 6. Nachmansohn, D.: Cholinesterase in Central Nervous System , Nature , London 140:427 ( (Sept. 4) ) 1937. 7. Fiamberti, A. M.: Accessi a carattere epilettico provocati con l'introduzione sottoccipitale di sostanze vasodilatrici , Riv. sper. di freniat. 61:834-840 ( (Dec.) ) 1937. 8. Brenner, C., and Merritt, H. H.: Unpublished data. 9. Rossi, A.: Ricerche sperimentali sulle convulsioni da acetilcolina , Note e riv. di psichiat. 68:229-239 ( (April) ) 1939. 10. Merritt, H. H.: Unpublished data. 11. Dikshit, B. B.: Acetylcholine Formation by Tissues , Quart. J. Exper. Physiol. 28:243-251 ( (Nov.) ) 1938. 12. Stedman, E.: Occurrence of Acetylcholine in Brain , J. Physiol. 89:37P ( (April 9) ) 1937. 13. Williams, D.: The Effect of Cholin-Like Substances on the Cerebral Electrical Discharges in Epilepsy , J. Neurol. & Psychiat. 4:32-47 ( (Jan.) ) 1941. 14. Merritt, H. H., and Putnam, T. J.: A New Series of Anticonvulsant Drugs Tested by Experiments on Animals , Arch. Neurol. & Psychiat. 39:1003-1015 ( (May) ) 1938. 15. Henderson, W. R., and Wilson, W. C.: Intraventricular Injection of Acetylcholine and Eserine in Man , Quart. J. Exper. Physiol. 26:83-95 ( (April) ) 1936. 16. Flexner, J., and Wright, I. S.: Effect of Acetyl-B-Methylcholine (Mecholyl) on Gastric Secretion in Animals and in Man , Am. J. Digest. Dis. 5:736-739 ( (Jan.) ) 1939. 17. de Wispelaere, H.: Actions de l'acétyl-B-méthylcholine, etc. sur la circulation et sur la respiration , Arch. internat. de pharmacodyn. et de thérap. 56:363-375 ( (Aug.) ) 1937. 18. Simonart, A.: On the Action of Certain Derivatives of Choline , J. Pharmacol. & Exper. Therap. 46:157-193 ( (Oct.) ) 1932.
Archives of Neurology & Psychiatry – American Medical Association
Published: Sep 1, 1942
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