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BIOCHEMICAL DISTURBANCES IN MENTAL DISORDERS: I. ANTI-INSULIN EFFECT OF BLOOD IN CASES OF SCHIZOPHRENIA

BIOCHEMICAL DISTURBANCES IN MENTAL DISORDERS: I. ANTI-INSULIN EFFECT OF BLOOD IN CASES OF... Abstract This paper is a report of the first phase of a research problem based on the assumption that in the insulin and the convulsive treatment of schizophrenia there are certain trends in the mode of action which are common to both and have been defined clearly enough to form a basis for further investigations. The experiments here reported were undertaken to test the assumption that one of the accompaniments, and possibly a basic factor, of schizophrenia may be a disturbance of the carbohydrate metabolism acting antagonistically, in a measure, to the normal carbohydrate metabolism. REPORT OF INVESTIGATION The first part of this work was done in cooperation with Dr. B. Rohny, of Budapest, Hungary. Three methods were followed in investigating the diabetogenic action of the anterior lobe of the hypophysis.1. The effect of Hoffman's "carbohydrate metabolism hormone" was determined. The method is as follows: The patient is first given References 1. Pearl, R.: Introduction to Medical Biometry and Statistics , ed. 3, Philadelphia, W. B. Saunders Company, 1940. 2. Banting, F. G.; Franks, W. R., and Gairns, S.: Anti-Insulin Activity of Serum of Insulin-Treated Patient , Am. J. Psychiat. 95:562, 1938. 3. Karelitz, S.; Cohen, P., and Leader, S. D.: Studies on Inhibition of Insulin Activity , Proc. Soc. Exper. Biol. & Med. 26:11, 1928. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology & Psychiatry American Medical Association

BIOCHEMICAL DISTURBANCES IN MENTAL DISORDERS: I. ANTI-INSULIN EFFECT OF BLOOD IN CASES OF SCHIZOPHRENIA

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References (3)

Publisher
American Medical Association
Copyright
Copyright © 1942 American Medical Association. All Rights Reserved.
ISSN
0096-6754
DOI
10.1001/archneurpsyc.1942.02290010048004
Publisher site
See Article on Publisher Site

Abstract

Abstract This paper is a report of the first phase of a research problem based on the assumption that in the insulin and the convulsive treatment of schizophrenia there are certain trends in the mode of action which are common to both and have been defined clearly enough to form a basis for further investigations. The experiments here reported were undertaken to test the assumption that one of the accompaniments, and possibly a basic factor, of schizophrenia may be a disturbance of the carbohydrate metabolism acting antagonistically, in a measure, to the normal carbohydrate metabolism. REPORT OF INVESTIGATION The first part of this work was done in cooperation with Dr. B. Rohny, of Budapest, Hungary. Three methods were followed in investigating the diabetogenic action of the anterior lobe of the hypophysis.1. The effect of Hoffman's "carbohydrate metabolism hormone" was determined. The method is as follows: The patient is first given References 1. Pearl, R.: Introduction to Medical Biometry and Statistics , ed. 3, Philadelphia, W. B. Saunders Company, 1940. 2. Banting, F. G.; Franks, W. R., and Gairns, S.: Anti-Insulin Activity of Serum of Insulin-Treated Patient , Am. J. Psychiat. 95:562, 1938. 3. Karelitz, S.; Cohen, P., and Leader, S. D.: Studies on Inhibition of Insulin Activity , Proc. Soc. Exper. Biol. & Med. 26:11, 1928.

Journal

Archives of Neurology & PsychiatryAmerican Medical Association

Published: Jan 1, 1942

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