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W. Gardner, O. Turner (1939)
MULTIPLE INTRACRANIAL TUMORS: A DISCUSSION OF THE RELATION OF MENINGEAL TO ACOUSTIC TUMORS AND A REPORT OF A CASEJAMA, 113
F. Recklinghausen
Ueber die multiplen Fibrome der Haut und ihre Beziehung zu den multiplen Neuromen
W. Penfield (1932)
TUMORS OF THE SHEATHS OF THE NERVOUS SYSTEMJournal of Nervous and Mental Disease, 27
W. J. Gardner (1930)
Bilateral Acoustic Neurofibromas: A Clinical Study and Field Survey of a Family of Five Generations with Bilateral Deafness in Thirty-Eight MembersArch. Neurol. & Psychiat., 23
W. J. Gardner (1930)
Tumor of the Spinal Cord Associated with Bilateral Acoustic Tumors: Report of a CaseArch. Neurol. & Psychiat., 24
A. Thomson (1900)
ON NEUROMA AND NEUNO-FIBROMATOSISThe American Journal of the Medical Sciences, 120
(1930)
Hereditary Deafness Due to Bilateral Acoustic Tumors: Clinical Study and Field Survey of a Family of Five Generations with a History of Bilateral Deafness in Thirty-Eight MembersAnn. Otol., Rhin. & Laryng., 39
G. Schaltenbrand (1933)
Sobre una familia con enfermedad de RecklinghausenPrensa méd. argent., 20
E. Berggrün (1896)
Ein Fall von allgemeiner Neurofibromatose bei einem 11jährigen KnabenArch. f. Kinderh., 21
W. Gardner, C. Frazier (1930)
BILATERAL ACOUSTIC NEUROFIBROMAS: A CLINICAL STUDY AND FIELD SURVEY OF A FAMILY OF FIVE GENERATIONS WITH BILATERAL DEAFNESS IN THIRTY-EIGHT MEMBERSJournal of Nervous and Mental Disease, 23
M. Hardy, S. Crowe (1936)
EARLY ASYMPTOMATIC ACOUSTIC TUMOR: REPORT OF SIX CASESArchives of Surgery, 32
H. Stallard (1938)
A CASE OF INTRA-OCULAR NEUROMA (VON RECKLINGHAUSEN'S DISEASE) OF THE LEFT OPTIC NERVE HEADBritish Journal of Ophthalmology, 22
W. Gardner (1930)
TUMOR OF THE SPINAL CORD ASSOCIATED WITH BILATERAL ACOUSTIC TUMORS: Report of a CaseJournal of Nervous and Mental Disease, 24
F. Struwe (1930)
Eine Recklinghausen-Familie. Klinische und anatomische UntersuchungenZtschr. f. d. ges. Neurol. u. Psychiat., 125
H. Roger , J. Alliez (1934)
Tumeur bilatérale de l'acoustique à forme familiale et héréditaireBull. et mém. Soc. méd. d. hôp. de Paris, 50
L. Minski (1932)
FAMILIAL BILATERAL ACOUSTIC TUMOURS*The Journal of Neurology and Psychopathology, s1-12
E. P. Fowler (1936)
Acoustic Tumors Within Internal Auditory MeatusLaryngoscope, 46
H. Cushing, L. Eisenhardt (1938)
Meningiomas : their classification, regional behaviour, life history, and surgical end results
W. Penfield (1932)
Cytology and Cellular Pathology of the Nervous System, 3
O. Turner, W. Gardner (1938)
Familial Involvement of the Nervous System by Multiple Tumors of the Sheaths and Enveloping Membranes: Hereditary, Clinical, and Pathological Study of Central and Peripheral NeurofibromatosisAmerican Journal of Cancer, 32
F. Struwe, E. Steuer (1930)
Eine Recklinghausen-FamilieZeitschrift für die gesamte Neurologie und Psychiatrie, 125
Abstract In 1930, Gardner and Frazier1 reported a family in which von Recklinghausen's disease, in the form of bilateral tumors of the acoustic nerve, had been transmitted as a dominant mendelian trait through five generations. At the time of the original report, 38 of the 217 members of the family were affected. Necropsy was performed on 2 members of the family and revealed bilateral acoustic neurofibromas. After the publication of the first report, symptoms of a tumor of the spinal cord developed in 1 of the affected members. This tumor was removed and likewise proved to be a neurofibroma; the case was subsequently reported by Gardner.2 The present report, the third concerning this family, deals chiefly with the pathologic material obtained from 4 members since the last publication.3 One of these members (case 4) represents the only case thus far observed in which the disease has been recognized References 1. Gardner, W. J., and Frazier, C. H.: Bilateral Acoustic Neurofibromas: A Clinical Study and Field Survey of a Family of Five Generations with Bilateral Deafness in Thirty-Eight Members , Arch. Neurol. & Psychiat. 23:266-300 ( (Feb.) ) 1930 2. Hereditary Deafness Due to Bilateral Acoustic Tumors: Clinical Study and Field Survey of a Family of Five Generations with a History of Bilateral Deafness in Thirty-Eight Members , Ann. Otol., Rhin. & Laryng. 39:974-986 ( (Dec.) ) 1930. 3. Gardner, W. J.: Tumor of the Spinal Cord Associated with Bilateral Acoustic Tumors: Report of a Case , Arch. Neurol. & Psychiat. 24:1014-1022 ( (Nov.) ) 1930. 4. The histologic sections were stained with hematoxylin and eosin and phosphotungstic acid hematoxylin and by Perdrau's silver impregnation method for connective tissue, Fincher's silver technic, Cajal's and Bielschowsky's silver methods for nerve fibers and, in some instances, by various stains for myelin sheaths. Some of the preparations, particularly those of necropsy material, suffered from the fact that the tissue was obtained long after death. However, in no instance were the postmortem changes so great as to interfere with a relatively detailed study of the tissue or to prevent recognition of the tumor type. 5. Gardner, W. J., and Turner, O. A.: Multiple Intracranial Tumors: A Discussion of the Relationship of Meningeal to Acoustic Tumors and a Report of a Case , J. A. M. A. 113:111-113 ( (July 8) ) 1939. 6. Cushing, H., and Eisenhardt, L.: Meningiomas: Their Classification, Regional Behavior, Life History, and Surgical End Results , Springfield, Ill., Charles C. Thomas, Publisher, 1938. 7. von Recklinghausen, F.: Ueber die multiplen Fibrome der Haut und ihre Beziehung zu den multiplen Neuromen , Berlin, A. Hirschwald, 1882. 8. Thomson, A.: On Neuroma and Neurofibromatosis , Edinburgh, Turnbull & Spears, 1900. 9. Struwe, F., and Steuer, E. J.: Eine Recklinghausen-Familie. Klinische und anatomische Untersuchungen , Ztschr. f. d. ges. Neurol. u. Psychiat. 125:748-790, 1930. 10. Minski, L.: Familial Bilateral Acoustic Tumours , J. Neurol. & Psychopath. 12:289-308 ( (April) ) 1932. 11. Schaltenbrand, G.: Sobre una familia con enfermedad de Recklinghausen , Prensa méd. argent. 20:1011-1026 ( (May 10) ) 1933. 12. Roger, H.; Alliez, J., and Sarradon, P.: Tumeur bilatérale de l'acoustique à forme familiale et héréditaire , Bull. et mém. Soc. méd. d. hôp. de Paris 50:235-240 ( (Feb. 19) ) 1934. 13. Stallard, H. B.: A Case of Intra-Ocular Neuroma (von Recklinghausen's Disease) of the Left Optic Nerve Head , Brit. J. Ophth. 22:11-18 ( (Jan.) ) 1938. 14. Turner, O. A., and Gardner, W. J.: Familial Involvement of the Nervous System by Multiple Tumors of the Sheaths and Enveloping Membranes: Hereditary, Clinical and Pathological Study of Central and Peripheral Neurofibromatosis , Am. J. Cancer 32:339-360 ( (March) ) 1938. 15. Penfield, W.: Tumors of the Sheaths of the Nervous System , in Cytology and Cellular Pathology of the Nervous System , New York, Paul B. Hoeber, Inc., 1932, vol. 3, pp. 955-990. 16. Footnote deleted. 17. Berggrün, E.: Ein Fall von allgemeiner Neurofibromatose bei einem 11jährigen Knaben , Arch. f. Kinderh. 21:89-113, 1896. 18. Hardy, M., and Crowe, S. J.: Early Asymptomatic Acoustic Tumor: Report of Six Cases , Arch. Surg. 32:292-301 ( (Feb.) ) 1936. 19. Fowler, E. P.: Acoustic Tumors Within Internal Auditory Meatus , Laryngoscope 46:616-627 ( (Aug.) ) 1936.
Archives of Neurology & Psychiatry – American Medical Association
Published: Jul 1, 1940
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