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ESTROGENIC THERAPY OF INVOLUTIONAL MELANCHOLIA

ESTROGENIC THERAPY OF INVOLUTIONAL MELANCHOLIA Abstract Standardized estrogenic preparations have been in use for the past ten years.1 There is general agreement that these substances are effective in the treatment of disorders of the climacteric, which are evidenced by such symptoms as hot flashes, dizziness, vasomotor imbalance and headache. Gynecologists are agreed that the majority of patients suffering from these menopausal symptoms are relieved, but admit that a few patients benefit little from treatment and that there is no adequate explanation of this failure. There is less agreement among psychiatrists as to the beneficial results of estrogenic therapy for involutional melancholia. Some workers2 have been enthusiastic in recommending such treatment, while others3 have reported results which seem to indicate that therapy of this type is not effective in cases of this disorder. During the early years in which estrogenic substances were given to patients with involutional melancholia, the dose reported seems now, in References 1. Reese, H. H.; Paskind, H. A., and Sevringhaus, E. L.: Year Book of Neurology, Psychiatry and Endocrinology for 1937 , Chicago, The Year Book Publishers, Inc., 1938, p. 660. 2. Ault, C. C.; Hoctor, E. F., and Werner, A. A.: Theelin Therapy in Psychoses: Effect in Involutional Melancholia and as Adjuvant in Other Mental Diseases , J. A. M. A. 109:1786-1788 ( (Nov. 27) ) 1937.Crossref 3. Suckle, J. E.: Treatment of Involutional Melancholia by Estrogen , J. A. M. A. 109:203-204 ( (July 17) ) 1937.Crossref 4. Werner, A. A.; Johns, G. A.; Hoctor, E. F.; Ault, C. C.; Kohler, L. H., and Weis, M. W.: Involutional Melancholia: Probable Etiology and Treatment , J. A. M. A. 103:13-16 ( (July 7) ) 1934.Crossref 5. Schube, P. G.: McManamy, M. C.; Frapp, C. E., and Houser, G. F.: Involutional Melancholia: Treatment with Theelin , Arch. Neurol. & Psychiat. 38:505-512 ( (Sept.) ) 1937. 6. Papanicolaou, G. N., and Shorr, E.: Action of Ovarian Follicular Hormone in Menopause as Indicated by Vaginal Smears , Am. J. Obst. & Gynec. 31:806-831 ( (May) ) 1936. 7. Papanicolaou, G. N.: Sexual Cycle in the Human Female as Revealed by Vaginal Smears , Am. J. Anat. ( (supp.) ) 52:519-637 (May) 1933. 8. Papanicolaou and Shorr.4 9. Lewis, R. M., and Weinstein, L.: Production of Vaginal Acidity by Estrin: Its Importance in the Treatment of Gonorrheal Vaginitis , Surg., Gynec. & Obst. 63:640-643 ( (Nov.) ) 1936. 10. Krumm, J. F.: Variations in the Glycogen Content of Vaginal Mucosa as Relative Index to Quantitative Amount of Ovarian Hormone Available in Organism , Am. J. Obst. & Gynec. 31:1035-1037 ( (June) ) 1936. 11. Henderson, D. K., and Gillespie, R. D.: A Textbook of Psychiatry for Students and Practitioners , ed. 2, New York, Oxford University Press, 1932. 12. Titley, W. B.: Prepsychotic Personality of Patients with Involutional Melancholia , Arch. Neurol. & Psychiat. 36:19-33 ( (July) ) 1936 13. Prepsychotic Personality of Patients with Agitated Depression , Titley Arch. Neurol. & Psychiat. 39:333-342 ( (Feb.) ) 1938. 14. The Schering Corporation, Bloomfield, N. J., supplied the progynon B used in this investigation. 15. Smith, G. Van S.: Personal communication to the author. 16. Malzberg, B.: Mortality Among Patients with Involutional Melancholia , Am. J. Psychiat. 93:1231-1238 ( (March) ) 1937. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology & Psychiatry American Medical Association

ESTROGENIC THERAPY OF INVOLUTIONAL MELANCHOLIA

DYNES, JOHN B.
Archives of Neurology & Psychiatry , Volume 42 (2) – Aug 1, 1939
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References (16)

Publisher
American Medical Association
Copyright
Copyright © 1939 American Medical Association. All Rights Reserved.
ISSN
0096-6754
DOI
10.1001/archneurpsyc.1939.02270200068007
Publisher site
See Article on Publisher Site

Abstract

Abstract Standardized estrogenic preparations have been in use for the past ten years.1 There is general agreement that these substances are effective in the treatment of disorders of the climacteric, which are evidenced by such symptoms as hot flashes, dizziness, vasomotor imbalance and headache. Gynecologists are agreed that the majority of patients suffering from these menopausal symptoms are relieved, but admit that a few patients benefit little from treatment and that there is no adequate explanation of this failure. There is less agreement among psychiatrists as to the beneficial results of estrogenic therapy for involutional melancholia. Some workers2 have been enthusiastic in recommending such treatment, while others3 have reported results which seem to indicate that therapy of this type is not effective in cases of this disorder. During the early years in which estrogenic substances were given to patients with involutional melancholia, the dose reported seems now, in References 1. Reese, H. H.; Paskind, H. A., and Sevringhaus, E. L.: Year Book of Neurology, Psychiatry and Endocrinology for 1937 , Chicago, The Year Book Publishers, Inc., 1938, p. 660. 2. Ault, C. C.; Hoctor, E. F., and Werner, A. A.: Theelin Therapy in Psychoses: Effect in Involutional Melancholia and as Adjuvant in Other Mental Diseases , J. A. M. A. 109:1786-1788 ( (Nov. 27) ) 1937.Crossref 3. Suckle, J. E.: Treatment of Involutional Melancholia by Estrogen , J. A. M. A. 109:203-204 ( (July 17) ) 1937.Crossref 4. Werner, A. A.; Johns, G. A.; Hoctor, E. F.; Ault, C. C.; Kohler, L. H., and Weis, M. W.: Involutional Melancholia: Probable Etiology and Treatment , J. A. M. A. 103:13-16 ( (July 7) ) 1934.Crossref 5. Schube, P. G.: McManamy, M. C.; Frapp, C. E., and Houser, G. F.: Involutional Melancholia: Treatment with Theelin , Arch. Neurol. & Psychiat. 38:505-512 ( (Sept.) ) 1937. 6. Papanicolaou, G. N., and Shorr, E.: Action of Ovarian Follicular Hormone in Menopause as Indicated by Vaginal Smears , Am. J. Obst. & Gynec. 31:806-831 ( (May) ) 1936. 7. Papanicolaou, G. N.: Sexual Cycle in the Human Female as Revealed by Vaginal Smears , Am. J. Anat. ( (supp.) ) 52:519-637 (May) 1933. 8. Papanicolaou and Shorr.4 9. Lewis, R. M., and Weinstein, L.: Production of Vaginal Acidity by Estrin: Its Importance in the Treatment of Gonorrheal Vaginitis , Surg., Gynec. & Obst. 63:640-643 ( (Nov.) ) 1936. 10. Krumm, J. F.: Variations in the Glycogen Content of Vaginal Mucosa as Relative Index to Quantitative Amount of Ovarian Hormone Available in Organism , Am. J. Obst. & Gynec. 31:1035-1037 ( (June) ) 1936. 11. Henderson, D. K., and Gillespie, R. D.: A Textbook of Psychiatry for Students and Practitioners , ed. 2, New York, Oxford University Press, 1932. 12. Titley, W. B.: Prepsychotic Personality of Patients with Involutional Melancholia , Arch. Neurol. & Psychiat. 36:19-33 ( (July) ) 1936 13. Prepsychotic Personality of Patients with Agitated Depression , Titley Arch. Neurol. & Psychiat. 39:333-342 ( (Feb.) ) 1938. 14. The Schering Corporation, Bloomfield, N. J., supplied the progynon B used in this investigation. 15. Smith, G. Van S.: Personal communication to the author. 16. Malzberg, B.: Mortality Among Patients with Involutional Melancholia , Am. J. Psychiat. 93:1231-1238 ( (March) ) 1937.

Journal

Archives of Neurology & Psychiatry – American Medical Association

Published: Aug 1, 1939

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