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SEQUELAE OF POSTMEASLES ENCEPHALOMYELITIS: A CLINICOPATHOLOGIC STUDY

SEQUELAE OF POSTMEASLES ENCEPHALOMYELITIS: A CLINICOPATHOLOGIC STUDY Abstract In the course of postmeasles encephalomyelitis, neurologic and mental disturbances resulting in permanent organic defective states may occur. Ford1 in reviewing 125 cases, including 12 of his own, found such residual symptoms in 65 per cent of patients who survived. The pathologic conditions underlying such organic disturbances have so far not been described, except for a few doubtful cases, which I shall discuss later. It is the purpose of this contribution to report 2 cases which illustrate clinically and pathoanatomically the sequelae of postmeasles encephalomyelitis and to trace the manner in which this terminal condition develops from the preceding acute and subacute stages, which have been outlined in a previous communication.2 Such an investigation may also be of value in differentiating disseminated encephalomyelitis from multiple and diffuse sclerosis, concerning which there is considerable confusion in the literature. REPORT OF CASES Case 1. —E. T., a white boy aged References 1. Ford, F. R.: The Nervous Complications of Measles , Bull. Johns Hopkins Hosp. 43:140 ( (Sept.) ) 1928. 2. Malamud, N.: Encephalomyelitis Complicating Measles , Arch. Neurol. & Psychiat. 38:1025 ( (Nov.) ) 1937. 3. Wohlwill, F.: Ueber Encephalomyelitis bei Masern , Ztschr. f. d. ges. Neurol. u. Psychiat. 112:20, 1928. 4. Pette, H.: Infektion und Nervensystem , Deutsche Ztschr. f. Nervenh. 110: 221 ( (Nov.) ) 1929. 5. Ferraro, A.: Primary Demyelinating Processes of the Central Nervous System , Arch. Neurol. & Psychiat. 37:1100 ( (May) ) 1937. 6. Putnam, T. J.: Studies in Multiple Sclerosis: Similarities Between Some Forms of "Encephalomyelitis" and Multiple Sclerosis , Arch. Neurol. & Psychiat. 35:1289 ( (June) ) 1936. 7. Cramer, A.: Beginnende multiple Sklerose und acute Myelitis , Arch. f. Psychiat. 19:667, 1888. 8. Schlesinger, H.: Zur Frage der akuten multiplen Sklerose und der Encephalomyelitis disseminata im Kindesalter , Arb. a. d. neurol. Inst. a. d. Wien. Univ. 17:410, 1909. 9. Gagel, O.: Zur Frage der diffusen Sklerose , Ztschr. f. d. ges. Neurol. u. Psychiat. 109:418, 1927. 10. McAlpine, D.: Acute Disseminated Encephalomyelitis: Its Sequelae and Its Relationship to Disseminated Sclerosis , Lancet 1:846 ( (April 18) ) 1931. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology & Psychiatry American Medical Association

SEQUELAE OF POSTMEASLES ENCEPHALOMYELITIS: A CLINICOPATHOLOGIC STUDY

MALAMUD, N.
Archives of Neurology & Psychiatry , Volume 41 (5) – May 1, 1939
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References (15)

Publisher
American Medical Association
Copyright
Copyright © 1939 American Medical Association. All Rights Reserved.
ISSN
0096-6754
DOI
10.1001/archneurpsyc.1939.02270170081004
Publisher site
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Abstract

Abstract In the course of postmeasles encephalomyelitis, neurologic and mental disturbances resulting in permanent organic defective states may occur. Ford1 in reviewing 125 cases, including 12 of his own, found such residual symptoms in 65 per cent of patients who survived. The pathologic conditions underlying such organic disturbances have so far not been described, except for a few doubtful cases, which I shall discuss later. It is the purpose of this contribution to report 2 cases which illustrate clinically and pathoanatomically the sequelae of postmeasles encephalomyelitis and to trace the manner in which this terminal condition develops from the preceding acute and subacute stages, which have been outlined in a previous communication.2 Such an investigation may also be of value in differentiating disseminated encephalomyelitis from multiple and diffuse sclerosis, concerning which there is considerable confusion in the literature. REPORT OF CASES Case 1. —E. T., a white boy aged References 1. Ford, F. R.: The Nervous Complications of Measles , Bull. Johns Hopkins Hosp. 43:140 ( (Sept.) ) 1928. 2. Malamud, N.: Encephalomyelitis Complicating Measles , Arch. Neurol. & Psychiat. 38:1025 ( (Nov.) ) 1937. 3. Wohlwill, F.: Ueber Encephalomyelitis bei Masern , Ztschr. f. d. ges. Neurol. u. Psychiat. 112:20, 1928. 4. Pette, H.: Infektion und Nervensystem , Deutsche Ztschr. f. Nervenh. 110: 221 ( (Nov.) ) 1929. 5. Ferraro, A.: Primary Demyelinating Processes of the Central Nervous System , Arch. Neurol. & Psychiat. 37:1100 ( (May) ) 1937. 6. Putnam, T. J.: Studies in Multiple Sclerosis: Similarities Between Some Forms of "Encephalomyelitis" and Multiple Sclerosis , Arch. Neurol. & Psychiat. 35:1289 ( (June) ) 1936. 7. Cramer, A.: Beginnende multiple Sklerose und acute Myelitis , Arch. f. Psychiat. 19:667, 1888. 8. Schlesinger, H.: Zur Frage der akuten multiplen Sklerose und der Encephalomyelitis disseminata im Kindesalter , Arb. a. d. neurol. Inst. a. d. Wien. Univ. 17:410, 1909. 9. Gagel, O.: Zur Frage der diffusen Sklerose , Ztschr. f. d. ges. Neurol. u. Psychiat. 109:418, 1927. 10. McAlpine, D.: Acute Disseminated Encephalomyelitis: Its Sequelae and Its Relationship to Disseminated Sclerosis , Lancet 1:846 ( (April 18) ) 1931.

Journal

Archives of Neurology & Psychiatry – American Medical Association

Published: May 1, 1939

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