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MYOCLONIC EPILEPSY

MYOCLONIC EPILEPSY Abstract From a chaotic group of hyperkinetic manifestations Friedreich separated an entity which was characterized by rapid, lightning-like twitchings of the muscles, or myoclonia. This syndrome, now known as Friedreich's paramyoclonus multiplex, he ascribed to abnormal irritability of the cells of the anterior horn. In 1891 Unverricht1 demarcated still another nosologic entity of myoclonic phenomena associated with epilepsy. He described several cases from the previous literature and added observations on a family composed of 5 sisters. These patients were afflicted between the ages of 6 and 13 years, first with generalized convulsions, followed in a few years by the onset of myoclonia consisting of irregular, arrhythmic lightning-like jerks of muscle groups without movements of the extremities. These affected both upper extremities first and involved the face last. Sleep abolished the movements; external disturbances, psychic upsets and volitional muscular effort increased them. Unverricht, too, expressed the belief that the myoclonia is References 1. Unverricht, H.: Die Myoclonie , Berlin, Franz Deuticke, 1891 2. Ueber familiäre Myoclonie , Deutsche Ztschr. f. Nervenh. 7:32, 1895.Crossref 3. Westphal, A.: Ueber eigenartige Einschlüsse in den Ganglienzellen (Corpora amylacea) bei einem Falle von Myoklonusepilepsie , Arch. f. Psychiat. 66: 769, 1919.Crossref 4. Pilotti, G.: Sulla presenza di corpi palini nel protoplasma delle cellule nervose del midollo spinale un caso di policlonia , Riv. sper. di freniat. 45:421, 1922. 5. Marchand, L.: Les myoclonies épileptiques , Encéphale 29:217, 1934. 6. Grinker, R. R.: Neurology , ed. 2, Springfield, Ill., Charles C. Thomas, Publisher, 1937, p. 840. 7. Lundborg, H.: Der Erbgang der progressiven Myoklonus-Epilepsie (Myoklonie-Epilepsie s. Unverrichts familiäre Myoklonie) , Ztschr. f. d. ges. Neurol. u. Psychiat. 9:353, 1912.Crossref 8. Hodskins, M. B., and Yakolev, P. I.: Anatomico-Clinical Observations on Myoclonus in Epileptics and on Related Symptom Complexes , Am. J. Psychiat. 9: 827, 1930. 9. Lafora, G. R., and Glueck, B.: Beitrag zur Histopathologie der myoklonischen Epilepsie , Ztschr. f. d. ges. Neurol. u. Psychiat. 6:1, 1911.Crossref 10. Westphal, A., and Sioli, F.: Weitere Mitteilung über den durch eigenartige Einschlüsse in den Ganglionzellen (Corpora amylacea) ausgezeichneten Fall von Myoklonusepilepsie , Arch. f. Psychiat. 62:1, 1921.Crossref 11. Marchand, L.: Dégénérescence amyloïde de la cellule nerveuse , Ann. d'anat. path. 12:1, 1935. 12. Spielmeyer, W.: Histopathologie des Nervensystems , Berlin, Julius Springer, 1922. 13. All electroencephalograms are to be read from right to left. 14. Gibbs, F. A.; Davis, H., and Lennox, W. G.: The Electro-Encephalogram in Epilepsy and in Conditions of Impaired Consciousness , Arch. Neurol. & Psychiat. 34:1133 ( (Dec.) ) 1935. 15. Gibbs, F. A.; Lennox, W. G., and Gibbs, E. L.: The Electro-Encephalogram in Diagnosis and Localization of Epileptic Seizures , Arch. Neurol. & Psychiat. 36:1225 ( (Dec.) ) 1936. 16. Lennox, W. G.; Gibbs, F. A., and Gibbs, E. L.: Effect on the Electro-Encephalogram of Drugs and Conditions Which Influence Seizures , Arch. Neurol. & Psychiat. 36:1236 ( (Dec.) ) 1936. 17. Berger, H.: Ueber das Elektrenkephalogramm des Menschen , Arch. f. Psychiat. 87:527, 1929 18. 100:301, 1933. 19. Kornmüller, A. E.: Der Mechanismus des epileptischen Anfalles auf Grundbiolektrischer Untersuchungen am Zentralnervensystem , Fortschr. d. Neurol., Psychiat. 7:391 and 414, 1935. 20. Gibbs, F. A.: Interpretations of the Electroencephalogram , J. Psychol. 4: 365, 1937. 21. Grinker, R. R.: A Method for Studying and Influencing Cortico-Hypothalamic Relations , Science 87:73, 1938. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology & Psychiatry American Medical Association

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References (19)

Publisher
American Medical Association
Copyright
Copyright © 1938 American Medical Association. All Rights Reserved.
ISSN
0096-6754
DOI
10.1001/archneurpsyc.1938.02270110122008
Publisher site
See Article on Publisher Site

Abstract

Abstract From a chaotic group of hyperkinetic manifestations Friedreich separated an entity which was characterized by rapid, lightning-like twitchings of the muscles, or myoclonia. This syndrome, now known as Friedreich's paramyoclonus multiplex, he ascribed to abnormal irritability of the cells of the anterior horn. In 1891 Unverricht1 demarcated still another nosologic entity of myoclonic phenomena associated with epilepsy. He described several cases from the previous literature and added observations on a family composed of 5 sisters. These patients were afflicted between the ages of 6 and 13 years, first with generalized convulsions, followed in a few years by the onset of myoclonia consisting of irregular, arrhythmic lightning-like jerks of muscle groups without movements of the extremities. These affected both upper extremities first and involved the face last. Sleep abolished the movements; external disturbances, psychic upsets and volitional muscular effort increased them. Unverricht, too, expressed the belief that the myoclonia is References 1. Unverricht, H.: Die Myoclonie , Berlin, Franz Deuticke, 1891 2. Ueber familiäre Myoclonie , Deutsche Ztschr. f. Nervenh. 7:32, 1895.Crossref 3. Westphal, A.: Ueber eigenartige Einschlüsse in den Ganglienzellen (Corpora amylacea) bei einem Falle von Myoklonusepilepsie , Arch. f. Psychiat. 66: 769, 1919.Crossref 4. Pilotti, G.: Sulla presenza di corpi palini nel protoplasma delle cellule nervose del midollo spinale un caso di policlonia , Riv. sper. di freniat. 45:421, 1922. 5. Marchand, L.: Les myoclonies épileptiques , Encéphale 29:217, 1934. 6. Grinker, R. R.: Neurology , ed. 2, Springfield, Ill., Charles C. Thomas, Publisher, 1937, p. 840. 7. Lundborg, H.: Der Erbgang der progressiven Myoklonus-Epilepsie (Myoklonie-Epilepsie s. Unverrichts familiäre Myoklonie) , Ztschr. f. d. ges. Neurol. u. Psychiat. 9:353, 1912.Crossref 8. Hodskins, M. B., and Yakolev, P. I.: Anatomico-Clinical Observations on Myoclonus in Epileptics and on Related Symptom Complexes , Am. J. Psychiat. 9: 827, 1930. 9. Lafora, G. R., and Glueck, B.: Beitrag zur Histopathologie der myoklonischen Epilepsie , Ztschr. f. d. ges. Neurol. u. Psychiat. 6:1, 1911.Crossref 10. Westphal, A., and Sioli, F.: Weitere Mitteilung über den durch eigenartige Einschlüsse in den Ganglionzellen (Corpora amylacea) ausgezeichneten Fall von Myoklonusepilepsie , Arch. f. Psychiat. 62:1, 1921.Crossref 11. Marchand, L.: Dégénérescence amyloïde de la cellule nerveuse , Ann. d'anat. path. 12:1, 1935. 12. Spielmeyer, W.: Histopathologie des Nervensystems , Berlin, Julius Springer, 1922. 13. All electroencephalograms are to be read from right to left. 14. Gibbs, F. A.; Davis, H., and Lennox, W. G.: The Electro-Encephalogram in Epilepsy and in Conditions of Impaired Consciousness , Arch. Neurol. & Psychiat. 34:1133 ( (Dec.) ) 1935. 15. Gibbs, F. A.; Lennox, W. G., and Gibbs, E. L.: The Electro-Encephalogram in Diagnosis and Localization of Epileptic Seizures , Arch. Neurol. & Psychiat. 36:1225 ( (Dec.) ) 1936. 16. Lennox, W. G.; Gibbs, F. A., and Gibbs, E. L.: Effect on the Electro-Encephalogram of Drugs and Conditions Which Influence Seizures , Arch. Neurol. & Psychiat. 36:1236 ( (Dec.) ) 1936. 17. Berger, H.: Ueber das Elektrenkephalogramm des Menschen , Arch. f. Psychiat. 87:527, 1929 18. 100:301, 1933. 19. Kornmüller, A. E.: Der Mechanismus des epileptischen Anfalles auf Grundbiolektrischer Untersuchungen am Zentralnervensystem , Fortschr. d. Neurol., Psychiat. 7:391 and 414, 1935. 20. Gibbs, F. A.: Interpretations of the Electroencephalogram , J. Psychol. 4: 365, 1937. 21. Grinker, R. R.: A Method for Studying and Influencing Cortico-Hypothalamic Relations , Science 87:73, 1938.

Journal

Archives of Neurology & PsychiatryAmerican Medical Association

Published: Nov 1, 1938

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