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WATER METABOLISM IN RELATION TO CONVULSIONS

WATER METABOLISM IN RELATION TO CONVULSIONS Abstract The factor of water balance has received much attention from many investigators of epilepsy and the convulsive state. Rowntree1 produced a condition which he designated as "water intoxication" by administering large amounts of water by stomach tube to various mammals (dog, cat, rabbit, guinea-pig and rat). A prominent feature of this toxic state was the occurrence of convulsions. He regarded such convulsions as the expression of an increase in intracranial pressure arising as a manifestation of disturbance in the salt to water equilibrium of the body and the central nervous system. The production of convulsions in animals by such forced administration of water suggested a possible disturbance of water balance in epilepsy occurring in man. Temple Fay2 and his co-workers were impressed by the possible significance of disturbed water balance and stated that "the predisposing factor concerned with a major convulsive seizure is due to a hydration state." References 1. Rowntree, L. G.: The Water Balance of the Body , Physiol. Rev. 2:116, 1922. 2. Fay, Temple: Epilepsy: Clinical Observations on the Control of Convulsive Seizures by Means of Dehydration , J. Nerv. & Ment. Dis. 71:481, 1930. 3. McQuarrie, I.: Epilepsy in Children: The Relationship of Water Balance to the Occurrence of Seizures , Am. J. Dis. Child. 38:451 ( (Sept.) ) 1929. 4. Gamble, J. L.: Dehydration , New England J. Med. 201:909 ( (Nov. 7) ) 1929. 5. Lyon, D. M., and Dunlop, D. M.: Epilepsy and Dehydration , Edinburgh M. J. 40:266, 1933. 6. Jacobsen, A. W.: Pitressin Test in Epilepsy , New York State J. Med. 34:506 ( (June 1) ) 1934. 7. Clegg, J. L., and Thorpe, F. T.: Induced Water Retention in Diagnosis of Idiopathic Epilepsy , Lancet 1:1381 ( (June 15) ) 1935. 8. Hartenberg, P.: La déshydratation dans le traitement de l'épilepsie , Presse méd. 39:101 ( (Jan. 21) ) 1931. 9. Peters, John P.: Body Water , Springfield, Ill., Charles C. Thomas, Publisher, 1935. 10. Wiggers, Carl J.: Physiology in Health and Disease , Philadelphia, Lea & Febiger, 1934. 11. Byrom, F. B.: Study of Total Exchange of Water, Sodium, Potassium and Nitrogen in Epilepsy , Quart. J. Med. 1:289, 1932. 12. Heller, H., and Smirk, F. H.: Studies Concerning the Alimentary Absorption of Water and Tissue Hydration in Relation to Diuresis , J. Physiol. 76:283 ( (Nov. 5) ) 1932. 13. Weir, J. F.; Larson, E. E., and Rowntree, L. G.: Studies in Diabetes Insipidus, Water Balance and Water Intoxication , Arch. Int. Med. 29:306 ( (March) ) 1922. 14. Priestley, J. G.: The Regulation of Excretion of Water by the Kidneys , J. Physiol. 50:304, 1916. 15. Crandall, L. A.: Personal communication to the authors. 16. Crandall, L. A., and Anderson, M. X.: Estimation on the State of Hydration of the Body by the Amount of Water Available for the Solution of Sodium Thiocyanate , Am. J. Digest. Dis. & Nutrition 1:126, 1934. 17. Fremont-Smith, F., and others: Studies in Edema: I. The Mechanism of Water Diuresis in Man , J. Clin. Investigation 9:7, 1930. 18. Gamble, J. L., and Hamilton, B.: The Acid-Base Composition of Urine from an Epileptic Child , Bull. Johns Hopkins Hosp. 41:389, 1927. 19. Hodskins, M. B.; Guthrie, R. H., and Naurison, J. Z.: Studies in Blood Volumes of Epileptics , Am. J. Psychiat. 11:623, 1931. 20. Lennox, W. G., and Cobb, S.: Epilepsy, from the Standpoint of Physiology and Treatment , Medicine 7:105, 1928. 21. Brown, R. D.: The Viscosity of the Blood in Epilepsy , J. Ment. Sc. 56:686, 1910. 22. Brühl, F.: Weitere blutchemische Untersuchungen zur Pathologie des epileptischen Krampfanfalles , Ztschr. f. d. ges. Neurol. u. Psychiat. 84:642, 1923. 23. Lennox, W. G.; O'Conner, M., and Wright, L. H.: Studies of the Metabolism in Epilepsy: I. Nonprotein Nitrogenous Constituents of Blood , Arch. Neurol. & Psychiat. 11:54 ( (Jan.) ) 1924. 24. Fletcher, R. T., and Pedan, O. D.: Blood Chemistry in Epilepsy , Lancet 1:1382 ( (June 15) ) 1935.Crossref 25. Keith, N. M.: Blood Volume Changes Following Water Abstinence , Am. J. Physiol. 59:452, 1922. 26. Cameron, D. E.: Dehydration Method in Epilepsy , Am. J. Psychiat. 11: 123, 1931. 27. Fetterman, J. L., and Kumin, H. J.: Dehydration in Epilepsy , J. A. M. A. 100:1005 ( (April 1) ) 1933.Crossref 28. Wilson, G., and Limberger, W. A.: Use of Dehydration in Epilepsy , J. A. M. A. 101:110 ( (July 8) ) 1933.Crossref 29. Stubbe Teglbjærg, H. P.: Investigations on Epilepsy and Water Metabolism , Acta psychiat. et neurol. , (supp. 9) , 1936, p. 1. 30. Ziskind, E., and Bolton, R.: Insulin Hypoglycemia in Epilepsy , Arch. Neurol. & Psychiat. 36:331 ( (Aug.) ) 1936. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology & Psychiatry American Medical Association

WATER METABOLISM IN RELATION TO CONVULSIONS

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References (36)

Publisher
American Medical Association
Copyright
Copyright © 1937 American Medical Association. All Rights Reserved.
ISSN
0096-6754
DOI
10.1001/archneurpsyc.1937.02260220142008
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Abstract

Abstract The factor of water balance has received much attention from many investigators of epilepsy and the convulsive state. Rowntree1 produced a condition which he designated as "water intoxication" by administering large amounts of water by stomach tube to various mammals (dog, cat, rabbit, guinea-pig and rat). A prominent feature of this toxic state was the occurrence of convulsions. He regarded such convulsions as the expression of an increase in intracranial pressure arising as a manifestation of disturbance in the salt to water equilibrium of the body and the central nervous system. The production of convulsions in animals by such forced administration of water suggested a possible disturbance of water balance in epilepsy occurring in man. Temple Fay2 and his co-workers were impressed by the possible significance of disturbed water balance and stated that "the predisposing factor concerned with a major convulsive seizure is due to a hydration state." References 1. Rowntree, L. G.: The Water Balance of the Body , Physiol. Rev. 2:116, 1922. 2. Fay, Temple: Epilepsy: Clinical Observations on the Control of Convulsive Seizures by Means of Dehydration , J. Nerv. & Ment. Dis. 71:481, 1930. 3. McQuarrie, I.: Epilepsy in Children: The Relationship of Water Balance to the Occurrence of Seizures , Am. J. Dis. Child. 38:451 ( (Sept.) ) 1929. 4. Gamble, J. L.: Dehydration , New England J. Med. 201:909 ( (Nov. 7) ) 1929. 5. Lyon, D. M., and Dunlop, D. M.: Epilepsy and Dehydration , Edinburgh M. J. 40:266, 1933. 6. Jacobsen, A. W.: Pitressin Test in Epilepsy , New York State J. Med. 34:506 ( (June 1) ) 1934. 7. Clegg, J. L., and Thorpe, F. T.: Induced Water Retention in Diagnosis of Idiopathic Epilepsy , Lancet 1:1381 ( (June 15) ) 1935. 8. Hartenberg, P.: La déshydratation dans le traitement de l'épilepsie , Presse méd. 39:101 ( (Jan. 21) ) 1931. 9. Peters, John P.: Body Water , Springfield, Ill., Charles C. Thomas, Publisher, 1935. 10. Wiggers, Carl J.: Physiology in Health and Disease , Philadelphia, Lea & Febiger, 1934. 11. Byrom, F. B.: Study of Total Exchange of Water, Sodium, Potassium and Nitrogen in Epilepsy , Quart. J. Med. 1:289, 1932. 12. Heller, H., and Smirk, F. H.: Studies Concerning the Alimentary Absorption of Water and Tissue Hydration in Relation to Diuresis , J. Physiol. 76:283 ( (Nov. 5) ) 1932. 13. Weir, J. F.; Larson, E. E., and Rowntree, L. G.: Studies in Diabetes Insipidus, Water Balance and Water Intoxication , Arch. Int. Med. 29:306 ( (March) ) 1922. 14. Priestley, J. G.: The Regulation of Excretion of Water by the Kidneys , J. Physiol. 50:304, 1916. 15. Crandall, L. A.: Personal communication to the authors. 16. Crandall, L. A., and Anderson, M. X.: Estimation on the State of Hydration of the Body by the Amount of Water Available for the Solution of Sodium Thiocyanate , Am. J. Digest. Dis. & Nutrition 1:126, 1934. 17. Fremont-Smith, F., and others: Studies in Edema: I. The Mechanism of Water Diuresis in Man , J. Clin. Investigation 9:7, 1930. 18. Gamble, J. L., and Hamilton, B.: The Acid-Base Composition of Urine from an Epileptic Child , Bull. Johns Hopkins Hosp. 41:389, 1927. 19. Hodskins, M. B.; Guthrie, R. H., and Naurison, J. Z.: Studies in Blood Volumes of Epileptics , Am. J. Psychiat. 11:623, 1931. 20. Lennox, W. G., and Cobb, S.: Epilepsy, from the Standpoint of Physiology and Treatment , Medicine 7:105, 1928. 21. Brown, R. D.: The Viscosity of the Blood in Epilepsy , J. Ment. Sc. 56:686, 1910. 22. Brühl, F.: Weitere blutchemische Untersuchungen zur Pathologie des epileptischen Krampfanfalles , Ztschr. f. d. ges. Neurol. u. Psychiat. 84:642, 1923. 23. Lennox, W. G.; O'Conner, M., and Wright, L. H.: Studies of the Metabolism in Epilepsy: I. Nonprotein Nitrogenous Constituents of Blood , Arch. Neurol. & Psychiat. 11:54 ( (Jan.) ) 1924. 24. Fletcher, R. T., and Pedan, O. D.: Blood Chemistry in Epilepsy , Lancet 1:1382 ( (June 15) ) 1935.Crossref 25. Keith, N. M.: Blood Volume Changes Following Water Abstinence , Am. J. Physiol. 59:452, 1922. 26. Cameron, D. E.: Dehydration Method in Epilepsy , Am. J. Psychiat. 11: 123, 1931. 27. Fetterman, J. L., and Kumin, H. J.: Dehydration in Epilepsy , J. A. M. A. 100:1005 ( (April 1) ) 1933.Crossref 28. Wilson, G., and Limberger, W. A.: Use of Dehydration in Epilepsy , J. A. M. A. 101:110 ( (July 8) ) 1933.Crossref 29. Stubbe Teglbjærg, H. P.: Investigations on Epilepsy and Water Metabolism , Acta psychiat. et neurol. , (supp. 9) , 1936, p. 1. 30. Ziskind, E., and Bolton, R.: Insulin Hypoglycemia in Epilepsy , Arch. Neurol. & Psychiat. 36:331 ( (Aug.) ) 1936.

Journal

Archives of Neurology & Psychiatry – American Medical Association

Published: Oct 1, 1937

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