Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

PERIVENOUS CHANGES IN ACUTE ENCEPHALITIS ASSOCIATED WITH VACCINATION, VARIOLA AND MEASLES

PERIVENOUS CHANGES IN ACUTE ENCEPHALITIS ASSOCIATED WITH VACCINATION, VARIOLA AND MEASLES Abstract The characteristic pathologic changes uniformly present in the acute stage of vaccinal encephalitis, first seen by Turnbull1 and described by Lucksch,2 encephalitis associated with variola (fig. 1 A), as described by Lucksch, and encephalitis following measles (fig. 1 B), as first described by Wohlwill,3 include a pathologic reaction not recognized before the last decade. This focal change is the perivascular, extra-adventitial and progressive glial reaction and demyelinization which occur along the course of veins for variable distances. In the present study small and large veins were involved but the medium and large vessels presented a marked glial reaction. Study of serial sections stained by the Nissl method showed that the small branches of a vein have no or a minimal glial reaction. As one follows the branch through to vessels of larger caliber the microglial collar about the vein becomes progressively more marked and more widespread. As References 1. Turnbull, H. M., and McIntosh, J.: Encephalomyelitis Following Vaccination , Brit. J. Exper. Path. 7:181, 1926. 2. Lucksch, Franz: Ueber Enzephalitis nach Varicellae, Variola, nach Vaccination und nach Morbilli , Med. Klin. 28:1554 ( (Nov. 4) ) 1932. 3. Wohlwill, F.: Ueber Encephalomyelitis bei Masern , Ztschr. f. d. ges. Neurol. u. Psychiat. 112:20, 1928.Crossref 4. Spielmeyer, W.: Local Vulnerability , Ztschr. f. d. ges. Neurol. u. Psychiat. 118:1 ( (Dec.) ) 1928Crossref 5. abstr., Arch. Neurol. & Psychiat. 23:161 ( (Jan.) ) 1930. 6. Putnam, Tracy J.: Studies in Multiple Sclerosis: IV. "Encephalitis" and Sclerotic Plaques Produced by Venular Obstruction , Arch. Neurol. & Psychiat. 33:929 ( (May) ) 1935. 7. Pfeifer, R. A.: Grundlegende Untersuchungen für die Angioarchitektonik des menschlichen Gehirns , Berlin, Julius Springer, 1930. 8. Personal observation on material in the Brain Anatomical Institute, University of Leipzig. 9. Adamkiewicz, Albert: Die Blutgefässe des menschlichen Rückenmarkes , Sitzungsb. d. k. Akad. d. Wissensch., Math.-naturw. Cl. 84:469, 1882. 10. Kadyi, H.: Ueber die Blutgefässe des menschlichen Rückenmarkes , Lemberg, Gubynowicz & Schmidt, 1889. 11. Personal communication to the author. 12. Putnam, Tracy J.: Evidences of Vascular Occlusion in Multiple Sclerosis and "Encephalomyelitis," Arch. Neurol. & Psychiat. , to be published. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology & Psychiatry American Medical Association

PERIVENOUS CHANGES IN ACUTE ENCEPHALITIS ASSOCIATED WITH VACCINATION, VARIOLA AND MEASLES

Archives of Neurology & Psychiatry , Volume 37 (3) – Mar 1, 1937

Loading next page...
 
/lp/american-medical-association/perivenous-changes-in-acute-encephalitis-associated-with-vaccination-xcprEhDWF6

References (8)

Publisher
American Medical Association
Copyright
Copyright © 1937 American Medical Association. All Rights Reserved.
ISSN
0096-6754
DOI
10.1001/archneurpsyc.1937.02260150035002
Publisher site
See Article on Publisher Site

Abstract

Abstract The characteristic pathologic changes uniformly present in the acute stage of vaccinal encephalitis, first seen by Turnbull1 and described by Lucksch,2 encephalitis associated with variola (fig. 1 A), as described by Lucksch, and encephalitis following measles (fig. 1 B), as first described by Wohlwill,3 include a pathologic reaction not recognized before the last decade. This focal change is the perivascular, extra-adventitial and progressive glial reaction and demyelinization which occur along the course of veins for variable distances. In the present study small and large veins were involved but the medium and large vessels presented a marked glial reaction. Study of serial sections stained by the Nissl method showed that the small branches of a vein have no or a minimal glial reaction. As one follows the branch through to vessels of larger caliber the microglial collar about the vein becomes progressively more marked and more widespread. As References 1. Turnbull, H. M., and McIntosh, J.: Encephalomyelitis Following Vaccination , Brit. J. Exper. Path. 7:181, 1926. 2. Lucksch, Franz: Ueber Enzephalitis nach Varicellae, Variola, nach Vaccination und nach Morbilli , Med. Klin. 28:1554 ( (Nov. 4) ) 1932. 3. Wohlwill, F.: Ueber Encephalomyelitis bei Masern , Ztschr. f. d. ges. Neurol. u. Psychiat. 112:20, 1928.Crossref 4. Spielmeyer, W.: Local Vulnerability , Ztschr. f. d. ges. Neurol. u. Psychiat. 118:1 ( (Dec.) ) 1928Crossref 5. abstr., Arch. Neurol. & Psychiat. 23:161 ( (Jan.) ) 1930. 6. Putnam, Tracy J.: Studies in Multiple Sclerosis: IV. "Encephalitis" and Sclerotic Plaques Produced by Venular Obstruction , Arch. Neurol. & Psychiat. 33:929 ( (May) ) 1935. 7. Pfeifer, R. A.: Grundlegende Untersuchungen für die Angioarchitektonik des menschlichen Gehirns , Berlin, Julius Springer, 1930. 8. Personal observation on material in the Brain Anatomical Institute, University of Leipzig. 9. Adamkiewicz, Albert: Die Blutgefässe des menschlichen Rückenmarkes , Sitzungsb. d. k. Akad. d. Wissensch., Math.-naturw. Cl. 84:469, 1882. 10. Kadyi, H.: Ueber die Blutgefässe des menschlichen Rückenmarkes , Lemberg, Gubynowicz & Schmidt, 1889. 11. Personal communication to the author. 12. Putnam, Tracy J.: Evidences of Vascular Occlusion in Multiple Sclerosis and "Encephalomyelitis," Arch. Neurol. & Psychiat. , to be published.

Journal

Archives of Neurology & PsychiatryAmerican Medical Association

Published: Mar 1, 1937

There are no references for this article.