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EFFECT OF HYPERVENTILATION ON THE EXCITABILITY OF THE MOTOR CORTEX IN CATS: AN EXPERIMENTAL STUDY

EFFECT OF HYPERVENTILATION ON THE EXCITABILITY OF THE MOTOR CORTEX IN CATS: AN EXPERIMENTAL STUDY Abstract It has long been known that minor symptoms of hyperexcitability of neuromuscular activity, such as twitchings of the muscles, diminution of the threshold of motor nerves, etc., designated under the syndrome of tetany, result from hyperventilation. In 1924, Rosett,1 in this country, and, almost simultaneously, Foerster,2 in Germany, applied this method of investigation to the study of diseases of the central nervous system, especially to epilepsy. This proved to be a successful conception, as both authors were able to show that hyperventilation in epileptic patients may produce marked symptoms of motor and sensory excitation and even true epileptic seizures. Foerster stated that he observed epileptiform seizures in 55 per cent of his patients. Many subsequent investigations confirmed this interesting observation, and the results were at variance only in respect to the percentage of cases in which epileptic seizures followed forced voluntary hyperventilation. Other clinicians have been unable to References 1. Rosett, J.: The Experimental Production of Rigidity, of Abnormal Involuntary Movements and of Abnormal States of Consciousness in Man , Brain 47: 293, 1924.Crossref 2. Foerster, O.: Hyperventilationsepilepsie , Zentralbl. f. d. ges. Neurol. u. Psychiat. 38:289, 1924. 3. The marking of the periods of stimulation on the recording drum was done manually by the closing and opening of an independent signal circuit at the moments of opening and the closing of the short circuit in the secondary circuit. Though it was tried to do this as accurately as possible, still this method occasionally results in small apparent differences of duration of the stimulations in the records (on the fast drum); the actual stimulations, however, throughout each experiment, were all of exactly the same duration. We adopted this method because we did not want to introduce a signal in the primary circuit, as this would probably have interfered with the uniformity of the stimulations. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology & Psychiatry American Medical Association

EFFECT OF HYPERVENTILATION ON THE EXCITABILITY OF THE MOTOR CORTEX IN CATS: AN EXPERIMENTAL STUDY

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References (2)

Publisher
American Medical Association
Copyright
Copyright © 1932 American Medical Association. All Rights Reserved.
ISSN
0096-6754
DOI
10.1001/archneurpsyc.1932.02240030091004
Publisher site
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Abstract

Abstract It has long been known that minor symptoms of hyperexcitability of neuromuscular activity, such as twitchings of the muscles, diminution of the threshold of motor nerves, etc., designated under the syndrome of tetany, result from hyperventilation. In 1924, Rosett,1 in this country, and, almost simultaneously, Foerster,2 in Germany, applied this method of investigation to the study of diseases of the central nervous system, especially to epilepsy. This proved to be a successful conception, as both authors were able to show that hyperventilation in epileptic patients may produce marked symptoms of motor and sensory excitation and even true epileptic seizures. Foerster stated that he observed epileptiform seizures in 55 per cent of his patients. Many subsequent investigations confirmed this interesting observation, and the results were at variance only in respect to the percentage of cases in which epileptic seizures followed forced voluntary hyperventilation. Other clinicians have been unable to References 1. Rosett, J.: The Experimental Production of Rigidity, of Abnormal Involuntary Movements and of Abnormal States of Consciousness in Man , Brain 47: 293, 1924.Crossref 2. Foerster, O.: Hyperventilationsepilepsie , Zentralbl. f. d. ges. Neurol. u. Psychiat. 38:289, 1924. 3. The marking of the periods of stimulation on the recording drum was done manually by the closing and opening of an independent signal circuit at the moments of opening and the closing of the short circuit in the secondary circuit. Though it was tried to do this as accurately as possible, still this method occasionally results in small apparent differences of duration of the stimulations in the records (on the fast drum); the actual stimulations, however, throughout each experiment, were all of exactly the same duration. We adopted this method because we did not want to introduce a signal in the primary circuit, as this would probably have interfered with the uniformity of the stimulations.

Journal

Archives of Neurology & Psychiatry – American Medical Association

Published: Sep 1, 1932

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