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Pervasive Ocular Tremor in Patients With Parkinson Disease

Pervasive Ocular Tremor in Patients With Parkinson Disease ORIGINAL CONTRIBUTION Pervasive Ocular Tremor in Patients With Parkinson Disease George T. Gitchel, MS; Paul A. Wetzel, PhD; Mark S. Baron, MD Objective: To further assess oculomotor control of pa- Results: All patients with PD and 2 of 60 control sub- tients with Parkinson disease (PD) during fixation and jects showed oscillatory fixation instability (ocular with movement. tremor), with an average fundamental frequency of 5.7 Hz and average magnitude of 0.27°. Saccadic para- Design: Case-control study. meters and occurrences of square wave jerks did not dif- fer between subjects with PD and controls. The ampli- Setting: A Parkinson disease research, education, and tude and frequency of fixation instability did not correlate clinical center. with disease duration, clinical Unified Parkinson’s Dis- ease Rating Scale scores, or dopa-equivalent dosing. No Patients: One hundred twelve patients with PD, includ- differences in oculomotor parameters were found be- ing 18 de novo untreated patients, and 60 age-matched tween medicated and unmedicated patients with PD. controls. Conclusions: All patients with PD exhibited persistent Intervention: Modern, precise eye tracking technol- ocular tremor that prevented stability during fixation. The ogy was used to assess oculomotor parameters. Oculo- pervasiveness and specificity of this feature suggest that motor function http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Neurology American Medical Association

Pervasive Ocular Tremor in Patients With Parkinson Disease

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References (29)

Publisher
American Medical Association
Copyright
Copyright 2012 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6149
eISSN
2168-6157
DOI
10.1001/archneurol.2012.70
pmid
22490323
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL CONTRIBUTION Pervasive Ocular Tremor in Patients With Parkinson Disease George T. Gitchel, MS; Paul A. Wetzel, PhD; Mark S. Baron, MD Objective: To further assess oculomotor control of pa- Results: All patients with PD and 2 of 60 control sub- tients with Parkinson disease (PD) during fixation and jects showed oscillatory fixation instability (ocular with movement. tremor), with an average fundamental frequency of 5.7 Hz and average magnitude of 0.27°. Saccadic para- Design: Case-control study. meters and occurrences of square wave jerks did not dif- fer between subjects with PD and controls. The ampli- Setting: A Parkinson disease research, education, and tude and frequency of fixation instability did not correlate clinical center. with disease duration, clinical Unified Parkinson’s Dis- ease Rating Scale scores, or dopa-equivalent dosing. No Patients: One hundred twelve patients with PD, includ- differences in oculomotor parameters were found be- ing 18 de novo untreated patients, and 60 age-matched tween medicated and unmedicated patients with PD. controls. Conclusions: All patients with PD exhibited persistent Intervention: Modern, precise eye tracking technol- ocular tremor that prevented stability during fixation. The ogy was used to assess oculomotor parameters. Oculo- pervasiveness and specificity of this feature suggest that motor function

Journal

JAMA Neurology – American Medical Association

Published: Aug 1, 2012

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