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SPECIAL ARTICLE Vladimir Hachinski, MD, FRCPC, DSc; Shahram Oveisgharan, MD; A. Kimball Romney, PhD; William R. Shankle, MS, MD Background: Vascular causes and factors remain the Results: Two optimized HIS versions were identified that most significant preventable component of cognitive dis- classify patients with vascular dementia vs those with non- orders of elderly individuals. The Hachinski Ischemic vascular dementia as well as or more accurately than the Score (HIS) is the questionnaire most commonly used original HIS instrument. Assuming the HIS instrument mea- for diagnosis of vascular dementia. sures only a single dimension, correspondence analysis iden- tified the 7 most discriminative HIS items. Binary scoring Objective: To consolidate and further validate the HIS. (0, 1) of these items led to a 7-item HIS model that classi- fied as well as the original 13-item HIS instrument. By merg- Design: The Canadian Study for Health and Aging was ing highly similar HIS items and applying correspon- used for this study. It was a cohort study conducted in 3 dence analysis, a 5-item composite HIS model was created waves in 1991, 1996-1997, and 2001-2002. The HIS con- that measures 2 meaningful dimensions of information and taining 13 items was subjected to correspondence
JAMA Neurology – American Medical Association
Published: Feb 1, 2012
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