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No Endovascular Innovation Without Evaluation in Chronic Cerebrospinal Venous Insufficiency

No Endovascular Innovation Without Evaluation in Chronic Cerebrospinal Venous Insufficiency EDITORIAL No Endovascular Innovation Without Evaluation in Chronic Cerebrospinal Venous Insufficiency A Call for the IDEAL Model ULTIPLE SCLEROSIS (MS) IS A CHRONIC entifically plausible relationship between CCSVI and MS neurodegenerative disorder of un- exists, whether it be causal or secondary. known cause. Inflammation, demy- The controversy, however, does not end with the elination, and neuroaxonal dysfunc- CCSVI criteria. Based on the theory that relief of CCSVI M tion contribute to its pathogenesis. It would be beneficial in MS, Zamboni et al published the has long been recognized that MS lesions tend to be peri- results of an unblinded pilot study of angioplasty and venular, which raises the possibility of a vascular cause. stenting of the jugular veins in patients with MS who met The vascular hypothesis for MS has recently received in- the CCSVI criteria and reported that gadolinium- creased attention owing to a series of studies by Zamboni enhanced lesions on magnetic resonance imaging “de- 1-3 and colleagues. Using cerebrovascular and cervicovas- creased significantly from 50% to 12%” and that in pa- cular ultrasonography, they report evidence of chronic ce- tients with relapsing-remitting MS, “mental and physical rebrospinal venous insufficiency (CCSVI) in all patients QOL [quality of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Neurology American Medical Association

No Endovascular Innovation Without Evaluation in Chronic Cerebrospinal Venous Insufficiency

Williams, Michael A.; Venkatesan, Arun
JAMA Neurology , Volume 68 (12) – Dec 1, 2011
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References (24)

Publisher
American Medical Association
Copyright
Copyright 2011 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6149
eISSN
2168-6157
DOI
10.1001/archneurol.2011.1555
pmid
22159051
Publisher site
See Article on Publisher Site

Abstract

EDITORIAL No Endovascular Innovation Without Evaluation in Chronic Cerebrospinal Venous Insufficiency A Call for the IDEAL Model ULTIPLE SCLEROSIS (MS) IS A CHRONIC entifically plausible relationship between CCSVI and MS neurodegenerative disorder of un- exists, whether it be causal or secondary. known cause. Inflammation, demy- The controversy, however, does not end with the elination, and neuroaxonal dysfunc- CCSVI criteria. Based on the theory that relief of CCSVI M tion contribute to its pathogenesis. It would be beneficial in MS, Zamboni et al published the has long been recognized that MS lesions tend to be peri- results of an unblinded pilot study of angioplasty and venular, which raises the possibility of a vascular cause. stenting of the jugular veins in patients with MS who met The vascular hypothesis for MS has recently received in- the CCSVI criteria and reported that gadolinium- creased attention owing to a series of studies by Zamboni enhanced lesions on magnetic resonance imaging “de- 1-3 and colleagues. Using cerebrovascular and cervicovas- creased significantly from 50% to 12%” and that in pa- cular ultrasonography, they report evidence of chronic ce- tients with relapsing-remitting MS, “mental and physical rebrospinal venous insufficiency (CCSVI) in all patients QOL [quality of

Journal

JAMA Neurology – American Medical Association

Published: Dec 1, 2011

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