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ORIGINAL CONTRIBUTION Enlarged Substantia Nigra Hyperechogenicity and Risk for Parkinson Disease A 37-Month 3-Center Study of 1847 Older Persons Daniela Berg, MD; Klaus Seppi, MD; Stefanie Behnke, MD; Inga Liepelt, PhD; Katherine Schweitzer, MD; Heike Stockner, MD; Frank Wollenweber, MD; Alexandra Gaenslen, MD; Philipp Mahlknecht, MD; Jo¨rg Spiegel, MD; Jana Godau, MD; Heiko Huber, MD; Karin Srulijes, MD; Stefan Kiechl, MD; Marianna Bentele; Arno Gasperi, MD; Teresa Schubert; Teresa Hiry; Mareike Probst; Vera Schneider; Jochen Klenk, PhD; Martin Sawires, MD; Johann Willeit, MD; Walter Maetzler, MD; Klaus Fassbender, MD; Thomas Gasser, MD; Werner Poewe, MD Objective: To evaluate whether enlarged substantia nigra Main Outcome Measure: Incidence of new-onset PD hyperechogenicity (SN) is associated with an in- in relation to baseline transcranial sonography status. creased risk for Parkinson disease (PD) in a healthy el- derly population. Results: There were 11 cases of incident PD during the follow-up period. In participants with SN at baseline, Design: Longitudinal 3-center observational study with the relative risk for incident PD was 17.37 (95% confi- 37 months of prospective follow-up. dence interval, 3.71-81.34) times higher compared with normoechogenic participants. Setting: Individuals 50 years or older without evidence of PD or any other neurodegenerative Conclusions: In
JAMA Neurology – American Medical Association
Published: Jul 1, 2011
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