Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Diet Intervention and Cerebrospinal Fluid Biomarkers in Amnestic Mild Cognitive Impairment

Diet Intervention and Cerebrospinal Fluid Biomarkers in Amnestic Mild Cognitive Impairment ORIGINAL CONTRIBUTION Diet Intervention and Cerebrospinal Fluid Biomarkers in Amnestic Mild Cognitive Impairment Jennifer L. Bayer-Carter, MS; Pattie S. Green, PhD; Thomas J. Montine, MD, PhD; Brian VanFossen, PhD; Laura D. Baker, PhD; G. Stennis Watson, PhD; Laura M. Bonner, PhD; Maureen Callaghan, MD; James B. Leverenz, MD; Brooke K. Walter, MD; Elaine Tsai, MD; Stephen R. Plymate, MD; Nadia Postupna, PhD; Charles W. Wilkinson, PhD; Jing Zhang, PhD; Johanna Lampe, PhD; Steven E. Kahn, MB, ChB; Suzanne Craft, PhD Objective: To compare the effects of a 4-week high– isoprostanes, and apolipoprotein E, plasma lipids and in- saturated fat/high–glycemic index (HIGH) diet with a low– sulin, and measures of cognition. saturated fat/low–glycemic index (LOW) diet on insulin and lipid metabolism, cerebrospinal fluid (CSF) markers Results: For the aMCI group, the LOW diet increased of Alzheimer disease, and cognition for healthy adults and CSF A42 concentrations, contrary to the pathologic pat- adults with amnestic mild cognitive impairment (aMCI). tern of lowered CSF A42 typically observed in Alzhei- mer disease. The LOW diet had the opposite effect for Design: Randomized controlled trial. healthy adults, ie, decreasing CSF A42, whereas the HIGH diet increased CSF A42. The CSF apolipopro- Setting: Veterans Affairs http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Neurology American Medical Association

Loading next page...
 
/lp/american-medical-association/diet-intervention-and-cerebrospinal-fluid-biomarkers-in-amnestic-mild-7bcF0eJ3TO

References (62)

Publisher
American Medical Association
Copyright
Copyright 2011 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6149
eISSN
2168-6157
DOI
10.1001/archneurol.2011.125
pmid
21670398
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL CONTRIBUTION Diet Intervention and Cerebrospinal Fluid Biomarkers in Amnestic Mild Cognitive Impairment Jennifer L. Bayer-Carter, MS; Pattie S. Green, PhD; Thomas J. Montine, MD, PhD; Brian VanFossen, PhD; Laura D. Baker, PhD; G. Stennis Watson, PhD; Laura M. Bonner, PhD; Maureen Callaghan, MD; James B. Leverenz, MD; Brooke K. Walter, MD; Elaine Tsai, MD; Stephen R. Plymate, MD; Nadia Postupna, PhD; Charles W. Wilkinson, PhD; Jing Zhang, PhD; Johanna Lampe, PhD; Steven E. Kahn, MB, ChB; Suzanne Craft, PhD Objective: To compare the effects of a 4-week high– isoprostanes, and apolipoprotein E, plasma lipids and in- saturated fat/high–glycemic index (HIGH) diet with a low– sulin, and measures of cognition. saturated fat/low–glycemic index (LOW) diet on insulin and lipid metabolism, cerebrospinal fluid (CSF) markers Results: For the aMCI group, the LOW diet increased of Alzheimer disease, and cognition for healthy adults and CSF A42 concentrations, contrary to the pathologic pat- adults with amnestic mild cognitive impairment (aMCI). tern of lowered CSF A42 typically observed in Alzhei- mer disease. The LOW diet had the opposite effect for Design: Randomized controlled trial. healthy adults, ie, decreasing CSF A42, whereas the HIGH diet increased CSF A42. The CSF apolipopro- Setting: Veterans Affairs

Journal

JAMA NeurologyAmerican Medical Association

Published: Jun 1, 2011

There are no references for this article.