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Frontal Paralimbic Network Atrophy in Very Mild Behavioral Variant Frontotemporal Dementia

Frontal Paralimbic Network Atrophy in Very Mild Behavioral Variant Frontotemporal Dementia ORIGINAL CONTRIBUTION Frontal Paralimbic Network Atrophy in Very Mild Behavioral Variant Frontotemporal Dementia William W. Seeley, MD; Richard Crawford, BS; Katya Rascovsky, PhD; Joel H. Kramer, PsyD; Michael Weiner, MD; Bruce L. Miller, MD; Maria Luisa Gorno-Tempini, MD, PhD Background: Behavioral variant frontotemporal de- white matter atrophy at each disease stage compared mentia (bvFTD) strikes hardest at the frontal lobes, but with controls. the sites of earliest injury remain unclear. Results: Patients with a CDR score of 0.5 had gray mat- Objective: To determine atrophy patterns in distinct ter loss in frontal paralimbic cortices, but atrophy also clinical stages of bvFTD, testing the hypothesis that the involved a network of anterior cortical and subcortical mildest stage is restricted to frontal paralimbic cortex. regions. A CDR score of 1 showed more extensive fron- tal gray matter atrophy and white matter losses in cor- Design: A bvFTD cohort study. pus callosum and brainstem. A CDR score of 2 to 3 showed additional posterior insula, hippocampus, and parietal Setting: University hospital dementia clinic. involvement, with white matter atrophy in presumed fron- tal projection fibers. Participants: Patients with bvFTD with Clinical De- mentia Rating (CDR) scale scores of 0.5 (n = 15), 1 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Neurology American Medical Association

Frontal Paralimbic Network Atrophy in Very Mild Behavioral Variant Frontotemporal Dementia

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References (47)

Publisher
American Medical Association
Copyright
Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6149
eISSN
2168-6157
DOI
10.1001/archneurol.2007.38
pmid
18268196
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL CONTRIBUTION Frontal Paralimbic Network Atrophy in Very Mild Behavioral Variant Frontotemporal Dementia William W. Seeley, MD; Richard Crawford, BS; Katya Rascovsky, PhD; Joel H. Kramer, PsyD; Michael Weiner, MD; Bruce L. Miller, MD; Maria Luisa Gorno-Tempini, MD, PhD Background: Behavioral variant frontotemporal de- white matter atrophy at each disease stage compared mentia (bvFTD) strikes hardest at the frontal lobes, but with controls. the sites of earliest injury remain unclear. Results: Patients with a CDR score of 0.5 had gray mat- Objective: To determine atrophy patterns in distinct ter loss in frontal paralimbic cortices, but atrophy also clinical stages of bvFTD, testing the hypothesis that the involved a network of anterior cortical and subcortical mildest stage is restricted to frontal paralimbic cortex. regions. A CDR score of 1 showed more extensive fron- tal gray matter atrophy and white matter losses in cor- Design: A bvFTD cohort study. pus callosum and brainstem. A CDR score of 2 to 3 showed additional posterior insula, hippocampus, and parietal Setting: University hospital dementia clinic. involvement, with white matter atrophy in presumed fron- tal projection fibers. Participants: Patients with bvFTD with Clinical De- mentia Rating (CDR) scale scores of 0.5 (n = 15), 1

Journal

JAMA NeurologyAmerican Medical Association

Published: Feb 1, 2008

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