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Impairment in Glomerular Filtration Rate or Glomerular Filtration Barrier and Occurrence of Stroke

Impairment in Glomerular Filtration Rate or Glomerular Filtration Barrier and Occurrence of Stroke ORIGINAL CONTRIBUTION Impairment in Glomerular Filtration Rate or Glomerular Filtration Barrier and Occurrence of Stroke Bruce Ovbiagele, MD Background: Chronic kidney disease (CKD) is associ- clearance) and glomerular filtration barrier (microal- ated with substantial burden and is a strong risk factor buminuria). for cardiovascular disease. However, data on the rela- Results: Of 6382 adults who met inclusion criteria, 5624 tionship between CKD and stroke are few and are lim- (88%) had full and complete data, of which 414 (6%) re- ited by unreliable or inadequate assessment of renal ported having had a stroke. Stroke survivors were older and function. more likely to have CKD, diabetes, hypertension, coro- Objective: To properly assess the relationship between nary artery disease, elevated blood pressure, increased gly- renal insufficiency and stroke in stroke survivors in the cohemoglobin concentration, and lower hematocrit com- United States by simultaneously examining the effect of pared with respondents who did not report stroke. guideline-recommended indices of renal disease that mea- Multivariate models showed that microalbuminuria (odds sure glomerular filtration rate (creatinine clearance) and ratio, 1.51; 95% confidence interval, 1.02-2.24), de- glomerular filtration barrier (proteinuria). creased glomerular filtration rate (odds ratio, 1.93; 95% con- fidence interval, 1.28-2.91), and stage 3 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Neurology American Medical Association

Impairment in Glomerular Filtration Rate or Glomerular Filtration Barrier and Occurrence of Stroke

JAMA Neurology , Volume 65 (7) – Jul 1, 2008

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References (42)

Publisher
American Medical Association
Copyright
Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6149
eISSN
2168-6157
DOI
10.1001/archneur.65.7.934
pmid
18625861
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL CONTRIBUTION Impairment in Glomerular Filtration Rate or Glomerular Filtration Barrier and Occurrence of Stroke Bruce Ovbiagele, MD Background: Chronic kidney disease (CKD) is associ- clearance) and glomerular filtration barrier (microal- ated with substantial burden and is a strong risk factor buminuria). for cardiovascular disease. However, data on the rela- Results: Of 6382 adults who met inclusion criteria, 5624 tionship between CKD and stroke are few and are lim- (88%) had full and complete data, of which 414 (6%) re- ited by unreliable or inadequate assessment of renal ported having had a stroke. Stroke survivors were older and function. more likely to have CKD, diabetes, hypertension, coro- Objective: To properly assess the relationship between nary artery disease, elevated blood pressure, increased gly- renal insufficiency and stroke in stroke survivors in the cohemoglobin concentration, and lower hematocrit com- United States by simultaneously examining the effect of pared with respondents who did not report stroke. guideline-recommended indices of renal disease that mea- Multivariate models showed that microalbuminuria (odds sure glomerular filtration rate (creatinine clearance) and ratio, 1.51; 95% confidence interval, 1.02-2.24), de- glomerular filtration barrier (proteinuria). creased glomerular filtration rate (odds ratio, 1.93; 95% con- fidence interval, 1.28-2.91), and stage 3

Journal

JAMA NeurologyAmerican Medical Association

Published: Jul 1, 2008

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