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Comparison of Clinical Manifestations in Alzheimer Disease and Dementia With Lewy Bodies

Comparison of Clinical Manifestations in Alzheimer Disease and Dementia With Lewy Bodies ORIGINAL CONTRIBUTION Comparison of Clinical Manifestations in Alzheimer Disease and Dementia With Lewy Bodies Angela Nervi, MD; Christiane Reitz, MD, PhD; Ming-Xin Tang, PhD; Vincent Santana, MBA; Angel Piriz, MD; Dolly Reyes-Dumeyer, BS; Rafael Lantigua, MD; Martin Medrano, MD; Ivonne Z. Jime´nez-Vela´zquez, MD; Joseph H. Lee, DrPH; Richard Mayeux, MD, MSc Background: The clinical delineation of dementia with heritable factors, we repeated analyses in the epidemio- Lewy bodies (DLB) from Alzheimer disease (AD) re- logic sample after excluding familial cases. We applied mains unclear. general linear models adjusted for age, sex, educational level, disease duration, and apolipoprotein E ε4 (OMIM Objectives: To compare neuropsychological profiles in 104310) genotype. DLB and AD among Caribbean Hispanic family mem- bers and participants in a population-based epidemio- Results: Patients with DLB in both samples were more logic sample using extended neuropsychological test bat- severely impaired in orientation, visuoconstruction, and teries and to explore whether these differences were related nonverbal reasoning after controlling for potential con- to heritable factors. founders. Patients having at least 2 family members with Design: Cross-sectional study. DLB had the most severe impairment in memory, fol- lowed by patients having 1 family member with DLB, and Setting: Clinics in northern http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Neurology American Medical Association

Comparison of Clinical Manifestations in Alzheimer Disease and Dementia With Lewy Bodies

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References (78)

Publisher
American Medical Association
Copyright
Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6149
eISSN
2168-6157
DOI
10.1001/archneur.65.12.1634
pmid
19064751
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL CONTRIBUTION Comparison of Clinical Manifestations in Alzheimer Disease and Dementia With Lewy Bodies Angela Nervi, MD; Christiane Reitz, MD, PhD; Ming-Xin Tang, PhD; Vincent Santana, MBA; Angel Piriz, MD; Dolly Reyes-Dumeyer, BS; Rafael Lantigua, MD; Martin Medrano, MD; Ivonne Z. Jime´nez-Vela´zquez, MD; Joseph H. Lee, DrPH; Richard Mayeux, MD, MSc Background: The clinical delineation of dementia with heritable factors, we repeated analyses in the epidemio- Lewy bodies (DLB) from Alzheimer disease (AD) re- logic sample after excluding familial cases. We applied mains unclear. general linear models adjusted for age, sex, educational level, disease duration, and apolipoprotein E ε4 (OMIM Objectives: To compare neuropsychological profiles in 104310) genotype. DLB and AD among Caribbean Hispanic family mem- bers and participants in a population-based epidemio- Results: Patients with DLB in both samples were more logic sample using extended neuropsychological test bat- severely impaired in orientation, visuoconstruction, and teries and to explore whether these differences were related nonverbal reasoning after controlling for potential con- to heritable factors. founders. Patients having at least 2 family members with Design: Cross-sectional study. DLB had the most severe impairment in memory, fol- lowed by patients having 1 family member with DLB, and Setting: Clinics in northern

Journal

JAMA Neurology – American Medical Association

Published: Dec 1, 2008

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