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Focal Cortical Dysplasia

Focal Cortical Dysplasia HISTORY OF NEUROLOGY: SEMINAL CITATION SECTION EDITOR: CHRISTOPHER G. GOETZ, MD Maria Augusta Montenegro, MD ocal cortical dysplasia (FCD) is a type of malformation of cortical development that pri- marily affects areas of neocortex. It can be identified on conventional magnetic reso- nance imaging as focal cortical thickening, abnormal gyration, and blurring between F gray and white matter, often associated with clusters of heterotopic neurons. Focal cor- tical dysplasia is one of the most common entities associated with refractory epilepsy, especially in childhood. 2,3 FIRST DESCRIPTION ous sclerosis was always mentioned. For many decades, FCD was considered a forme Taylor and colleagues wrote the first clear frusteoftuberoussclerosis.AccordingtoTay- description of FCD in their report of patho- loretal, “Thelackofsomanyoftheremark- logical findings in lobectomy specimens ably distinctive features of tuberous sclero- from epilepsy surgery: “The most striking sismay,however,notruleoutthecondition, microscopic feature at low power was the particularly as formes frustes are known to localized disruption of the normal cortical occur occasionally....” lamination by an excess of large aberrant Today, however, FCD is classified as neurons scattered randomly through all but an entity apart from tuberous sclerosis, and the first layer....The aberrant nerve cells it is interesting that, in 1957, Crome stated stood out http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Neurology American Medical Association

Focal Cortical Dysplasia

Montenegro, Maria Augusta
JAMA Neurology , Volume 60 (4) – Apr 1, 2003
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References (12)

Publisher
American Medical Association
Copyright
Copyright 2003 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6149
eISSN
2168-6157
DOI
10.1001/archneur.60.4.634
pmid
12707084
Publisher site
See Article on Publisher Site

Abstract

HISTORY OF NEUROLOGY: SEMINAL CITATION SECTION EDITOR: CHRISTOPHER G. GOETZ, MD Maria Augusta Montenegro, MD ocal cortical dysplasia (FCD) is a type of malformation of cortical development that pri- marily affects areas of neocortex. It can be identified on conventional magnetic reso- nance imaging as focal cortical thickening, abnormal gyration, and blurring between F gray and white matter, often associated with clusters of heterotopic neurons. Focal cor- tical dysplasia is one of the most common entities associated with refractory epilepsy, especially in childhood. 2,3 FIRST DESCRIPTION ous sclerosis was always mentioned. For many decades, FCD was considered a forme Taylor and colleagues wrote the first clear frusteoftuberoussclerosis.AccordingtoTay- description of FCD in their report of patho- loretal, “Thelackofsomanyoftheremark- logical findings in lobectomy specimens ably distinctive features of tuberous sclero- from epilepsy surgery: “The most striking sismay,however,notruleoutthecondition, microscopic feature at low power was the particularly as formes frustes are known to localized disruption of the normal cortical occur occasionally....” lamination by an excess of large aberrant Today, however, FCD is classified as neurons scattered randomly through all but an entity apart from tuberous sclerosis, and the first layer....The aberrant nerve cells it is interesting that, in 1957, Crome stated stood out

Journal

JAMA Neurology – American Medical Association

Published: Apr 1, 2003

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