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HISTORY OF NEUROLOGY: SEMINAL CITATIONS SECTION EDITOR: CHRISTOPHER G. GOETZ, MD Neurological Manifestations in Sjo ¨ gren Syndrome Catherine Lafitte, MD, PhD jo ¨ gren syndrome (SS) is a systemic autoimmune inflammatory disorder characterized by lymphocytic infiltration of exocrine glands with absent or diminished glandular se- cretion. The salivary and lacrimal glands are primarily involved, leading to dry eyes (xe- S rophthalmia with keratoconjunctivitis sicca) and mouth (xerostomia). Cases of xe- rophthalmia and/or xerostomia were first mentioned in the late 19th and early 20th centuries. In 1933, studying these symptoms and their related manifestations, Sjo ¨ gren, the Swedish ophthal- mologist, concluded that they were manifestations of a general disease. Since then, the syndrome including xerophthalmia with keratoconjunctivitis and xerostomia bears Sjo ¨ gren’s name. Because systemic complications of SS were In 1945, Weber described nonocular not thoroughly studied before 1960, these features of SS in several case reports, 2 of seminal citations on neurological mani- them with nervous system involvement: festations in SS refer to relatively recent Through Dr. Lauber, I have heard of a case of work. Some important aspects of neuro- dry mouth (? probably of the nature of Sjo ¨- logical complications in SS were
JAMA Neurology – American Medical Association
Published: Mar 1, 2000
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