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Posterior Cortical Atrophy: Neuropathological Correlations

Posterior Cortical Atrophy: Neuropathological Correlations Abstract We have been following with much interest the articles in the Archives1,2 regarding posterior cortical atrophy because case 5 in the original report1 has been 1 of our clinic patients. This patient, who initially presented at age 54 years with visual complaints, recently died after a 13-year course of progressive dementia. Neuropathological examination has revealed the presence of Alzheimer disease with numerous senile plaques and neurofibrillary tangles involving the frontal, temporal, and parietal neocortex; the hippocampus; and the pyriform cortex. Although there were also numerous plaques involving the occipital cortex, only a few tangles were present in that region. Our results are consistent with the neuropathological findings of Victoroff et al2 and other investigators who have studied cases of posterior cortical atrophy3,4 and suggest that Alzheimer disease should be considered as 1 of the primary causes in its differential diagnosis. With the caution that no occipital References 1. Benson DF, Davis RJ, Snyder BD. Posterior cortical atrophy . Arch Neurol . 1988; 45:789-793.Crossref 2. Victoroff J, Ross GW, Benson DF, Verity MA, Vinters HV. Posterior cortical atrophy: neuropathologic correlations . Arch Neurol . 1994;51:269-274.Crossref 3. Berthier ML, Leiguarda R, Starkstein SE, Sevlever G, Taratuto AL. Alzheimer's disease in a patient with posterior cortical atrophy . J Neurol Neurosurg Psychiatry . 1991;54:1110-1111.Crossref 4. Levine DN, Lee JM, Fisher CM. The visual variant of Alzheimer's disease: a clinicopathologic case study . Neurology . 1993;43:305-313.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Posterior Cortical Atrophy: Neuropathological Correlations

Posterior Cortical Atrophy: Neuropathological Correlations

Abstract

Abstract We have been following with much interest the articles in the Archives1,2 regarding posterior cortical atrophy because case 5 in the original report1 has been 1 of our clinic patients. This patient, who initially presented at age 54 years with visual complaints, recently died after a 13-year course of progressive dementia. Neuropathological examination has revealed the presence of Alzheimer disease with numerous senile plaques and neurofibrillary tangles involving the frontal,...
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References (5)

Publisher
American Medical Association
Copyright
Copyright © 1996 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1996.00550100020006
Publisher site
See Article on Publisher Site

Abstract

Abstract We have been following with much interest the articles in the Archives1,2 regarding posterior cortical atrophy because case 5 in the original report1 has been 1 of our clinic patients. This patient, who initially presented at age 54 years with visual complaints, recently died after a 13-year course of progressive dementia. Neuropathological examination has revealed the presence of Alzheimer disease with numerous senile plaques and neurofibrillary tangles involving the frontal, temporal, and parietal neocortex; the hippocampus; and the pyriform cortex. Although there were also numerous plaques involving the occipital cortex, only a few tangles were present in that region. Our results are consistent with the neuropathological findings of Victoroff et al2 and other investigators who have studied cases of posterior cortical atrophy3,4 and suggest that Alzheimer disease should be considered as 1 of the primary causes in its differential diagnosis. With the caution that no occipital References 1. Benson DF, Davis RJ, Snyder BD. Posterior cortical atrophy . Arch Neurol . 1988; 45:789-793.Crossref 2. Victoroff J, Ross GW, Benson DF, Verity MA, Vinters HV. Posterior cortical atrophy: neuropathologic correlations . Arch Neurol . 1994;51:269-274.Crossref 3. Berthier ML, Leiguarda R, Starkstein SE, Sevlever G, Taratuto AL. Alzheimer's disease in a patient with posterior cortical atrophy . J Neurol Neurosurg Psychiatry . 1991;54:1110-1111.Crossref 4. Levine DN, Lee JM, Fisher CM. The visual variant of Alzheimer's disease: a clinicopathologic case study . Neurology . 1993;43:305-313.Crossref

Journal

Archives of NeurologyAmerican Medical Association

Published: Oct 1, 1996

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