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Treatment of Multiple Sclerosis: Trial Design, Results, and Future Perspectives

Treatment of Multiple Sclerosis: Trial Design, Results, and Future Perspectives This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract This compact multiauthored volume provides essential information for anyone who is, or plans to become, involved in clinical trials in multiple sclerosis. In addition, it provides vital information for any neurologist interested in evaluating therapeutic claims for new therapies. The historical perspective provided by George Ellison is clear, concise, and informative. The chapter on natural history by Dr Goodkin is outstanding, as is the chapter on assessment of outcome by Drs. D. Paty, E. Willoughby, and J. Whitaker. While the chapter on design and statistical issues is well written, clearly states the requirements for planning studies, and discusses the major statistical issues, this reviewer disagrees strongly with one of their conclusions, namely that "admission to the trial should be restricted to those patients whose Kurtzke Extended Disability Status Scale (EDSS) is 3.5 or less." This conclusion is justified if one accepts the EDSS as the only or principal basis for http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Treatment of Multiple Sclerosis: Trial Design, Results, and Future Perspectives

Archives of Neurology , Volume 51 (7) – Jul 1, 1994

Treatment of Multiple Sclerosis: Trial Design, Results, and Future Perspectives

Abstract

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract This compact multiauthored volume provides essential information for anyone who is, or plans to become, involved in clinical trials in multiple sclerosis. In addition, it provides vital information for any neurologist interested in evaluating therapeutic claims for new therapies. The historical perspective provided by George Ellison is clear, concise,...
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Publisher
American Medical Association
Copyright
Copyright © 1994 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1994.00540190017005
Publisher site
See Article on Publisher Site

Abstract

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract This compact multiauthored volume provides essential information for anyone who is, or plans to become, involved in clinical trials in multiple sclerosis. In addition, it provides vital information for any neurologist interested in evaluating therapeutic claims for new therapies. The historical perspective provided by George Ellison is clear, concise, and informative. The chapter on natural history by Dr Goodkin is outstanding, as is the chapter on assessment of outcome by Drs. D. Paty, E. Willoughby, and J. Whitaker. While the chapter on design and statistical issues is well written, clearly states the requirements for planning studies, and discusses the major statistical issues, this reviewer disagrees strongly with one of their conclusions, namely that "admission to the trial should be restricted to those patients whose Kurtzke Extended Disability Status Scale (EDSS) is 3.5 or less." This conclusion is justified if one accepts the EDSS as the only or principal basis for

Journal

Archives of NeurologyAmerican Medical Association

Published: Jul 1, 1994

There are no references for this article.