Biologically Significant Serum Vitamin B12 Deficiency in Multiple Sclerosis Inadequately Documented
Abstract
Abstract To the Editor. —The recent article by Reynolds et al1 on potential association of vitamin B12 "deficiency" and multiple sclerosis (MS) is of considerable interest to patients with MS and physicians involved in their care. The significance of this observation, however, remains unclear because convincing evidence of a vitamin B12deficiency in patients with MS was not documented by the authors. Although the serum vitamin B12 assay is an extremely sensitive test for a...