Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Two Decades of Increasing Mortality From Parkinson's Disease Among the US Elderly

Two Decades of Increasing Mortality From Parkinson's Disease Among the US Elderly Abstract • To examine the possible role of environmental factors in the cause of Parkinson's disease (PD), we reviewed mortality trends for PD in the United States from 1962 through 1984. We found that age-specific mortality for PD in all demographic groups had changed notably during this 23-year interval. Among whites of both sexes, substantial declines were observed among the middle-aged, while notable increases were seen in the geriatric age groups. Similar changes were found in nonwhites; among nonwhites in the geriatric age range, increases of 22% to 553% were observed among men and 12% to 157% were observed among women. Men generally had a 100% higher risk of death due to PD than did women. Whites were at three times the risk of nonwhites. The observed temporal changes appear to reflect improved treatment, better case ascertainment, and a true rise in the incidence of PD, particularly among the elderly. This rise may be due to preventable environmental causes and will require further investigation. References 1. Calne S, Schoenberg B, Martin W, Uitti RJ, Spencer P, Calne DB. Familial Parkinson's disease: possible role of environmental factors . Can J Neurol Sci . 1987;14:303-305. 2. Calne DB, Eisen A, McGeer E, Spencer P. Alzheimer's disease, Parkinson's disease, and motor neurone disease: A biotrophic interaction between ageing and environment? Lancet . 1986;2:1067-1070.Crossref 3. Langston JW, Ballard P. Chronic parkinsonism in humans due to a product of meperidine-analog synthesis . Science . 1983;219:979-980.Crossref 4. Mena I, Marin O, Fuenzulida S, Cotzias GC. Chronic manganese poisoning . Neurology . 1967;17:128-136.Crossref 5. National Academy of Sciences, National Research Council, Committee on Sulfur Oxides, Board on Toxicology and Environmental Health Hazards, Assembly of Life Sciences . Sulfur Oxides . Washington, DC: National Academy of Sciences; 1978. 6. Tanner CM. The role of environmental toxins in the etiology of Parkinson's disease . Trends Neurosci . 1989;12:49-52.Crossref 7. World Health Organization. International Classification of Diseases, Seventh Revision . Geneva, Switzerland: World Health Organization; 1957. 8. World Health Organization. International Classification of Diseases, Eighth Revision . Bethesda, Md: National Center of Health Statistics; 1968. 9. World Health Organization. International Classification of Diseases, Ninth Revision . Bethesda, Md: National Center of Health Statistics; 1975. 10. Kurtzke JR. ICD 9: a regression . Am J Epidemiol . 1979;109:383-393. 11. Lilienfeld A, Lilienfeld DE. Foundations of Epidemiology . 2nd ed. New York, NY: Oxford University Press Inc; 1980. 12. US Department of Health, Education and Welfare. Vital Statistics of the United States 1960: Natality . Washington, DC: US Public Health Service; 1960:1. 13. Armitage P. Statistical Methods for Medical Research . Boston, Mass: Blackwell Scientific Publications Inc; 1971. 14. Fleiss JL. Statistical Methods for Rates and Proportions . New York, NY: John Wiley & Sons Inc; 1973. 15. Kondo K, Kurland LT. Parkinson's disease: genetic analysis and evidence of a multifactorial etiology . Mayo Clinic Proc . 1973;48:465-475. 16. Paddison RM, Griffith RP. Occurrence of Parkinson's disease in black patients at Charity Hospital in New Orleans . Neurology . 1974;24:688-690.Crossref 17. Kessler II. Epidemiologic studies of Parkinson's disease, II: a hospital-based survey . Am J Epidemiol . 1972;95:308-318. 18. Kessler II. Epidemiologic studies of Parkinson's disease, III: a community-based survey . Am J Epidemiol . 1972;96:242-254. 19. Goldberg ID, Kurland LT. Mortality in 33 countries from diseases of the nervous system . World Neurol . 1961;3:444-465. 20. Webster DD, Mortimer JA, Kuskowski MA. Long-term effect of levodopa on progression of Parkinson's disease . Adv Neurol . 1986;45:473-476. 21. Yahr MD, Duvoisin RC, Schear MJ, Barrett RE, Hoehn MM. Treatment of parkinsonism with levodopa . Arch Neurol . 1969;21:343-354.Crossref 22. Calne DB. Parkinsonism: physiology and pharmacology . BMJ . 1971;3:693-697.Crossref 23. Poskanzer DC, Schwab RS. Studies in the epidemiology of Parkinson's disease predicting its disappearance as a major clinical entity by 1980 . Trans Am Neurol Assoc . 1961;86:234-235. 24. Poskanzer DC, Schwab RS. Cohort analysis of Parkinson's syndrome: evidence for a single etiology related to subclinical infection about 1920 . J Chronic Dis . 1963;16:961-973.Crossref 25. Israel RA, Rosenberg HM, Curtin LR. Analytical potential for multiple cause-of-death data . Am J Epidemiol . 1986;124:161-179. 26. Chandra V, Bharucha NE, Schoenberg BS. Mortality data for the US for deaths due to and related to twenty neurologic deaths . Neuroepidemiology . 1984;3:149-168.Crossref 27. Lilienfeld DE, Chan E, Ehland J, et al. Increasing mortality from motor neuron disease in the United States during the past two decades . Lancet . 1988;1:710-712. 28. Calne DB, Langston JW. Aetiology of Parkinson's disease . Lancet . 1983;1:1457-1459.Crossref 29. Bollner F, Mizutani T, Roessman U, Gambetti P. Parkinson disease, dementia, and Alzheimer disease: clinicopathological correlations . Ann Neurol . 1980;7:329-335.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Two Decades of Increasing Mortality From Parkinson's Disease Among the US Elderly

Download PDF
4 pages

Loading next page...
 
/lp/american-medical-association/two-decades-of-increasing-mortality-from-parkinson-s-disease-among-the-IBO81TaNbd

References (29)

Publisher
American Medical Association
Copyright
Copyright © 1990 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1990.00530070019005
Publisher site
See Article on Publisher Site

Abstract

Abstract • To examine the possible role of environmental factors in the cause of Parkinson's disease (PD), we reviewed mortality trends for PD in the United States from 1962 through 1984. We found that age-specific mortality for PD in all demographic groups had changed notably during this 23-year interval. Among whites of both sexes, substantial declines were observed among the middle-aged, while notable increases were seen in the geriatric age groups. Similar changes were found in nonwhites; among nonwhites in the geriatric age range, increases of 22% to 553% were observed among men and 12% to 157% were observed among women. Men generally had a 100% higher risk of death due to PD than did women. Whites were at three times the risk of nonwhites. The observed temporal changes appear to reflect improved treatment, better case ascertainment, and a true rise in the incidence of PD, particularly among the elderly. This rise may be due to preventable environmental causes and will require further investigation. References 1. Calne S, Schoenberg B, Martin W, Uitti RJ, Spencer P, Calne DB. Familial Parkinson's disease: possible role of environmental factors . Can J Neurol Sci . 1987;14:303-305. 2. Calne DB, Eisen A, McGeer E, Spencer P. Alzheimer's disease, Parkinson's disease, and motor neurone disease: A biotrophic interaction between ageing and environment? Lancet . 1986;2:1067-1070.Crossref 3. Langston JW, Ballard P. Chronic parkinsonism in humans due to a product of meperidine-analog synthesis . Science . 1983;219:979-980.Crossref 4. Mena I, Marin O, Fuenzulida S, Cotzias GC. Chronic manganese poisoning . Neurology . 1967;17:128-136.Crossref 5. National Academy of Sciences, National Research Council, Committee on Sulfur Oxides, Board on Toxicology and Environmental Health Hazards, Assembly of Life Sciences . Sulfur Oxides . Washington, DC: National Academy of Sciences; 1978. 6. Tanner CM. The role of environmental toxins in the etiology of Parkinson's disease . Trends Neurosci . 1989;12:49-52.Crossref 7. World Health Organization. International Classification of Diseases, Seventh Revision . Geneva, Switzerland: World Health Organization; 1957. 8. World Health Organization. International Classification of Diseases, Eighth Revision . Bethesda, Md: National Center of Health Statistics; 1968. 9. World Health Organization. International Classification of Diseases, Ninth Revision . Bethesda, Md: National Center of Health Statistics; 1975. 10. Kurtzke JR. ICD 9: a regression . Am J Epidemiol . 1979;109:383-393. 11. Lilienfeld A, Lilienfeld DE. Foundations of Epidemiology . 2nd ed. New York, NY: Oxford University Press Inc; 1980. 12. US Department of Health, Education and Welfare. Vital Statistics of the United States 1960: Natality . Washington, DC: US Public Health Service; 1960:1. 13. Armitage P. Statistical Methods for Medical Research . Boston, Mass: Blackwell Scientific Publications Inc; 1971. 14. Fleiss JL. Statistical Methods for Rates and Proportions . New York, NY: John Wiley & Sons Inc; 1973. 15. Kondo K, Kurland LT. Parkinson's disease: genetic analysis and evidence of a multifactorial etiology . Mayo Clinic Proc . 1973;48:465-475. 16. Paddison RM, Griffith RP. Occurrence of Parkinson's disease in black patients at Charity Hospital in New Orleans . Neurology . 1974;24:688-690.Crossref 17. Kessler II. Epidemiologic studies of Parkinson's disease, II: a hospital-based survey . Am J Epidemiol . 1972;95:308-318. 18. Kessler II. Epidemiologic studies of Parkinson's disease, III: a community-based survey . Am J Epidemiol . 1972;96:242-254. 19. Goldberg ID, Kurland LT. Mortality in 33 countries from diseases of the nervous system . World Neurol . 1961;3:444-465. 20. Webster DD, Mortimer JA, Kuskowski MA. Long-term effect of levodopa on progression of Parkinson's disease . Adv Neurol . 1986;45:473-476. 21. Yahr MD, Duvoisin RC, Schear MJ, Barrett RE, Hoehn MM. Treatment of parkinsonism with levodopa . Arch Neurol . 1969;21:343-354.Crossref 22. Calne DB. Parkinsonism: physiology and pharmacology . BMJ . 1971;3:693-697.Crossref 23. Poskanzer DC, Schwab RS. Studies in the epidemiology of Parkinson's disease predicting its disappearance as a major clinical entity by 1980 . Trans Am Neurol Assoc . 1961;86:234-235. 24. Poskanzer DC, Schwab RS. Cohort analysis of Parkinson's syndrome: evidence for a single etiology related to subclinical infection about 1920 . J Chronic Dis . 1963;16:961-973.Crossref 25. Israel RA, Rosenberg HM, Curtin LR. Analytical potential for multiple cause-of-death data . Am J Epidemiol . 1986;124:161-179. 26. Chandra V, Bharucha NE, Schoenberg BS. Mortality data for the US for deaths due to and related to twenty neurologic deaths . Neuroepidemiology . 1984;3:149-168.Crossref 27. Lilienfeld DE, Chan E, Ehland J, et al. Increasing mortality from motor neuron disease in the United States during the past two decades . Lancet . 1988;1:710-712. 28. Calne DB, Langston JW. Aetiology of Parkinson's disease . Lancet . 1983;1:1457-1459.Crossref 29. Bollner F, Mizutani T, Roessman U, Gambetti P. Parkinson disease, dementia, and Alzheimer disease: clinicopathological correlations . Ann Neurol . 1980;7:329-335.Crossref

Journal

Archives of Neurology – American Medical Association

Published: Jul 1, 1990

There are no references for this article.