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Chronic Manganese Intoxication

Chronic Manganese Intoxication Abstract • We report six cases of chronic manganese intoxication in workers at a ferromanganese factory in Taiwan. Diagnosis was confirmed by assessing increased manganese concentrations in the blood, scalp, and pubic hair. In addition, increased manganese levels in the environmental air were established. The patients showed a bradykinetic-rigid syndrome indistinguishable from Parkinson's disease that responded to treatment with levodopa. References 1. Couper J. On the effects of black oxide of manganese when inhaled into the lungs . Br Ann Med Pharmacol . 1837;1:41-42. 2. Mena I. Manganese poisoning . In: Vinken PJ, Bruyn GW, eds. Handbook of Clinical Neurology . Amsterdam, the Netherlands: North-Holland Publishing Co, 1979;36:217-237. 3. Yamada M, Ohno S, Okayasy I, et al. Chronic manganese poisoning: a neuropathological study with determination of manganese distribution in the brain . Acta Neuropathol (Berl) . 1986;70:723-728.Crossref 4. Penalver R. Diagnosis and treatment of manganese intoxication . Arch Industr Health . 1957;16:64. 5. Archibald FS, Tyree C. Manganese poisoning and the attack of trivalent manganese upon catecholamines . Arch Biochem Biophys . 1987;256:638-650.Crossref 6. Neff NH, Barrett RE, Costa E. Selective depletion of caudate nucleus dopamine and serotonin during chronic manganese dioxide administration to squirrel monkeys . Experientia . 1969;25:1140-1141.Crossref 7. Donaldson J. Involvement of manganese in physiological and biochemical processes: an overview . Neurotoxicology . 1984;5:1-4. 8. Rosenstock HA, Simons DG, Meyer JS. Chronic manganism: neurologic and laboratory studies during treatment with levodopa . JAMA . 1971;217:1354-1358.Crossref 9. Cotzias GC, Papavasiliou PS, Gellene R. Modification of parkinsonism: chronic treatment with L-dopa . N Engl J Med . 1969;280:337-345.Crossref 10. Rodier J, Mallet R, Rodi L. Etude de l'action detoxicante de l'ethylene-diaminetetraacete de calcium dans l'intoxication experimentale par le manganese . Arch Mal Prof . 1954;15:210-223. 11. Cook DG, Fahn S, Brait KA. Chronic manganese intoxication . Arch Neurol . 1974;30:59-64.Crossref 12. Cotzias GC, Horiuchi K, Fuenzalida S, Mena I. Chronic manganese poisoning: clearance of tissue manganese concentrations with persistence of the neurological picture . Neurology . 1968;18:376-382.Crossref 13. Benton AL, Hamsher KdeS, Varney N, Spreen O. Facial recognition . In: Benton AL, Hamsher KdeS, eds. Contributions to Neuropsychological Assessment: A Clinical Manual . New York, NY: Oxford University Press; 1983:30-40. 14. Laker M. On determining trace element levels in man: the uses of blood and hair . Lancet . 1982;2:260-262.Crossref 15. Calne DB, Teychenn PF, Claveria LE, Eastman R, Greenacre JK, Petrie A. Bromocriptine in parkinsonism . Br Med J . 1974;4:442-444.Crossref 16. National Institute of Occupational Safety and Health (NIOSH). Manganese and compounds. In: NIOSH Manual of Analytic Methods. 2nd ed. Cincinnati, Ohio: National Institute of Occupational Safety and Health; 1977:S5 1-6. US Dept of Health, Education, and Welfare (NIOSH) publication 77-157. 17. American Conference of Governmental Industrial Hygienists (ACGIH). Threshold limit values for chemical substances in the work environment adopted by ACGIH . Cincinnati, Ohio: ACGIH, 1986;12:22. 18. Choi IIS. Delay neurologic sequelae in carbon monoxide intoxication . Arch Neurol . 1983;40:433-435.Crossref 19. Smith JS, Brandon S. Morbidity from acute carbon monoxide poisoning at three year follow-up . Br Med J . 1973;1:318-321.Crossref 20. Barbeau A. Manganese and extrapyramidal disorders . Neurotoxicology . 1984;5:13-36. 21. Tang LC. A personal and scientific biography of Dr. George C. Cotzias . Neurotoxicology . 1984;5:5-12. 22. Parenti M, Flauto C, Parati E, Vescovi A, Groppetti A. Manganese neurotoxicity: effects of L-dopa and pargyline treatments . Brain Res . 1986;367:8-13.Crossref 23. Calne DB, Langston JW. Etiology of Parkinson's disease . Lancet . 1983;2:1457-1459.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

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References (22)

Publisher
American Medical Association
Copyright
Copyright © 1989 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1989.00520460090018
Publisher site
See Article on Publisher Site

Abstract

Abstract • We report six cases of chronic manganese intoxication in workers at a ferromanganese factory in Taiwan. Diagnosis was confirmed by assessing increased manganese concentrations in the blood, scalp, and pubic hair. In addition, increased manganese levels in the environmental air were established. The patients showed a bradykinetic-rigid syndrome indistinguishable from Parkinson's disease that responded to treatment with levodopa. References 1. Couper J. On the effects of black oxide of manganese when inhaled into the lungs . Br Ann Med Pharmacol . 1837;1:41-42. 2. Mena I. Manganese poisoning . In: Vinken PJ, Bruyn GW, eds. Handbook of Clinical Neurology . Amsterdam, the Netherlands: North-Holland Publishing Co, 1979;36:217-237. 3. Yamada M, Ohno S, Okayasy I, et al. Chronic manganese poisoning: a neuropathological study with determination of manganese distribution in the brain . Acta Neuropathol (Berl) . 1986;70:723-728.Crossref 4. Penalver R. Diagnosis and treatment of manganese intoxication . Arch Industr Health . 1957;16:64. 5. Archibald FS, Tyree C. Manganese poisoning and the attack of trivalent manganese upon catecholamines . Arch Biochem Biophys . 1987;256:638-650.Crossref 6. Neff NH, Barrett RE, Costa E. Selective depletion of caudate nucleus dopamine and serotonin during chronic manganese dioxide administration to squirrel monkeys . Experientia . 1969;25:1140-1141.Crossref 7. Donaldson J. Involvement of manganese in physiological and biochemical processes: an overview . Neurotoxicology . 1984;5:1-4. 8. Rosenstock HA, Simons DG, Meyer JS. Chronic manganism: neurologic and laboratory studies during treatment with levodopa . JAMA . 1971;217:1354-1358.Crossref 9. Cotzias GC, Papavasiliou PS, Gellene R. Modification of parkinsonism: chronic treatment with L-dopa . N Engl J Med . 1969;280:337-345.Crossref 10. Rodier J, Mallet R, Rodi L. Etude de l'action detoxicante de l'ethylene-diaminetetraacete de calcium dans l'intoxication experimentale par le manganese . Arch Mal Prof . 1954;15:210-223. 11. Cook DG, Fahn S, Brait KA. Chronic manganese intoxication . Arch Neurol . 1974;30:59-64.Crossref 12. Cotzias GC, Horiuchi K, Fuenzalida S, Mena I. Chronic manganese poisoning: clearance of tissue manganese concentrations with persistence of the neurological picture . Neurology . 1968;18:376-382.Crossref 13. Benton AL, Hamsher KdeS, Varney N, Spreen O. Facial recognition . In: Benton AL, Hamsher KdeS, eds. Contributions to Neuropsychological Assessment: A Clinical Manual . New York, NY: Oxford University Press; 1983:30-40. 14. Laker M. On determining trace element levels in man: the uses of blood and hair . Lancet . 1982;2:260-262.Crossref 15. Calne DB, Teychenn PF, Claveria LE, Eastman R, Greenacre JK, Petrie A. Bromocriptine in parkinsonism . Br Med J . 1974;4:442-444.Crossref 16. National Institute of Occupational Safety and Health (NIOSH). Manganese and compounds. In: NIOSH Manual of Analytic Methods. 2nd ed. Cincinnati, Ohio: National Institute of Occupational Safety and Health; 1977:S5 1-6. US Dept of Health, Education, and Welfare (NIOSH) publication 77-157. 17. American Conference of Governmental Industrial Hygienists (ACGIH). Threshold limit values for chemical substances in the work environment adopted by ACGIH . Cincinnati, Ohio: ACGIH, 1986;12:22. 18. Choi IIS. Delay neurologic sequelae in carbon monoxide intoxication . Arch Neurol . 1983;40:433-435.Crossref 19. Smith JS, Brandon S. Morbidity from acute carbon monoxide poisoning at three year follow-up . Br Med J . 1973;1:318-321.Crossref 20. Barbeau A. Manganese and extrapyramidal disorders . Neurotoxicology . 1984;5:13-36. 21. Tang LC. A personal and scientific biography of Dr. George C. Cotzias . Neurotoxicology . 1984;5:5-12. 22. Parenti M, Flauto C, Parati E, Vescovi A, Groppetti A. Manganese neurotoxicity: effects of L-dopa and pargyline treatments . Brain Res . 1986;367:8-13.Crossref 23. Calne DB, Langston JW. Etiology of Parkinson's disease . Lancet . 1983;2:1457-1459.Crossref

Journal

Archives of NeurologyAmerican Medical Association

Published: Oct 1, 1989

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