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A Direct Electron Microscopic Immunocytochemical Study of IgM Paraproteinemic Neuropathy

A Direct Electron Microscopic Immunocytochemical Study of IgM Paraproteinemic Neuropathy Abstract • Direct electron microscopic immunohistochemistry of the sural nerve of a patient with neuropathy and an IgMk paraprotein demonstrated that immunoglobulin was deposited throughout the compact myelin. These findings support the notion that immunoglobulin deposition plays a role in the pathogenesis of the neuropathy in vivo. References 1. Latov N, Sherman W, Nemni R, et al: Plasma cell dyscrasia and peripheral neuropathy with a monoclonal antibody to peripheral nerve myelin . N Engl J Med 1980;303:618-621.Crossref 2. Smith IS, Kahn SN, Lacey BW, et al: Chronic demyelinating neuropathy associated with benign IgM paraproteinemia . Brain 1983;106:169-195.Crossref 3. Braun PR, Frail D, Latov N: MAG is the antigen for a monoclonal antibody in patients with a demyelinating neuropathy . J Neurochem 1982;39:1261-1265.Crossref 4. Ilyas A, Quarles R, Macintosh T, et al: IgM in a human neuropathy related to paraproteinemia binds to a carbohydrate determinant in the myelin-associated glycoprotein and to a ganglioside . Proc Natl Acad Sci USA 1984;81:1225-1229.Crossref 5. Abrams G, Latov N, Hays A, et al: Immunocytochemical studies of human peripheral nerve with serum from patients with polyneuropathy and paraproteinemia . Neurology 1982;32:821-826.Crossref 6. Takatsu M, Hays A, Latov N, et al: Immunofluorescence study of patients with neuropathy and IgM M proteins . Ann Neurol 1985;18:173-181.Crossref 7. Mendell J, Sahenk Z, Whitaker J, et al: Polyneuropathy and IgM monoclonal gammopathy: Studies on the pathogenic role of anti— myelin-associated glycoprotein antibody . Ann Neurol 1985;17:243-254.Crossref 8. Quarles RH, Pasnak CF: A rapid procedure for selectively isolating the major glycoprotein from purified rat brain myelin . Biochem J 1977;163:635-637. 9. Blake MS, Johnston KH, Russell-Jones GJ, et al: A rapid, sensitive method for detection of alkaline phosphatase-conjugated antibody on Western blots . Anal Biochem 1984;136:175-179.Crossref 10. Webster H, Palkovits C, Stoner G, et al: Myelin-associated glycoprotein: Electron microscopic immunocytochemical localization in compact developing and adult central nervous system myelin . J Neurochem 1983;41:1469-1470.Crossref 11. Trapp B, Quarles R: Immunocytochemical localization of the myelin-associated glycoprotein: Fact or artifact? J Neuroimmunol 1984;6:231-249.Crossref 12. Hays A, Latov N, Takatsu N: Experimental demyelination of nerve induced by serum of patients with neuropathy and an anti-MAG IgM M-protein . Neurology 1987;37:242-256.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

A Direct Electron Microscopic Immunocytochemical Study of IgM Paraproteinemic Neuropathy

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References (14)

Publisher
American Medical Association
Copyright
Copyright © 1988 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1988.00520300113031
Publisher site
See Article on Publisher Site

Abstract

Abstract • Direct electron microscopic immunohistochemistry of the sural nerve of a patient with neuropathy and an IgMk paraprotein demonstrated that immunoglobulin was deposited throughout the compact myelin. These findings support the notion that immunoglobulin deposition plays a role in the pathogenesis of the neuropathy in vivo. References 1. Latov N, Sherman W, Nemni R, et al: Plasma cell dyscrasia and peripheral neuropathy with a monoclonal antibody to peripheral nerve myelin . N Engl J Med 1980;303:618-621.Crossref 2. Smith IS, Kahn SN, Lacey BW, et al: Chronic demyelinating neuropathy associated with benign IgM paraproteinemia . Brain 1983;106:169-195.Crossref 3. Braun PR, Frail D, Latov N: MAG is the antigen for a monoclonal antibody in patients with a demyelinating neuropathy . J Neurochem 1982;39:1261-1265.Crossref 4. Ilyas A, Quarles R, Macintosh T, et al: IgM in a human neuropathy related to paraproteinemia binds to a carbohydrate determinant in the myelin-associated glycoprotein and to a ganglioside . Proc Natl Acad Sci USA 1984;81:1225-1229.Crossref 5. Abrams G, Latov N, Hays A, et al: Immunocytochemical studies of human peripheral nerve with serum from patients with polyneuropathy and paraproteinemia . Neurology 1982;32:821-826.Crossref 6. Takatsu M, Hays A, Latov N, et al: Immunofluorescence study of patients with neuropathy and IgM M proteins . Ann Neurol 1985;18:173-181.Crossref 7. Mendell J, Sahenk Z, Whitaker J, et al: Polyneuropathy and IgM monoclonal gammopathy: Studies on the pathogenic role of anti— myelin-associated glycoprotein antibody . Ann Neurol 1985;17:243-254.Crossref 8. Quarles RH, Pasnak CF: A rapid procedure for selectively isolating the major glycoprotein from purified rat brain myelin . Biochem J 1977;163:635-637. 9. Blake MS, Johnston KH, Russell-Jones GJ, et al: A rapid, sensitive method for detection of alkaline phosphatase-conjugated antibody on Western blots . Anal Biochem 1984;136:175-179.Crossref 10. Webster H, Palkovits C, Stoner G, et al: Myelin-associated glycoprotein: Electron microscopic immunocytochemical localization in compact developing and adult central nervous system myelin . J Neurochem 1983;41:1469-1470.Crossref 11. Trapp B, Quarles R: Immunocytochemical localization of the myelin-associated glycoprotein: Fact or artifact? J Neuroimmunol 1984;6:231-249.Crossref 12. Hays A, Latov N, Takatsu N: Experimental demyelination of nerve induced by serum of patients with neuropathy and an anti-MAG IgM M-protein . Neurology 1987;37:242-256.Crossref

Journal

Archives of NeurologyAmerican Medical Association

Published: Jun 1, 1988

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