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Angiotensin-Converting Enzyme in Neurosarcoidosis

Angiotensin-Converting Enzyme in Neurosarcoidosis Abstract To the Editor. —We read with great interest the article by Sethi et al in the June 1986 issue of the Archives.1 We wish to point out another important aspect of neurosarcoidosis that was not discussed by the authors, namely, determination of angiotensin I—converting enzyme (ACE) levels in the cerebrospinal fluid (CSF) of patients with suspected neurosarcoidosis.2-5High levels of CSF ACE may support the diagnosis of neurosarcoidosis even though the serum ACE levels are within the normal range.2,3 Furthermore, monitoring the CSF ACE levels may aid in patient management and follow-up, since CSF ACE levels decrease when the disease is clinically remitted due to corticosteroid therapy.3,5 There is no correlation between the serum and CSF ACE levels in patients with neurosarcoidosis, nor is there any correlation between CSF ACE and CSF total protein or albumin levels in such cases.3 The CSF ACE is most References 1. Sethi KD, El Gammal T, Patel BR, et al: Dural sarcoidosis presenting with transient neurologic symptoms . Arch Neurol 1986;43:595-597.Crossref 2. Schweisfurth H, Schioberg-Schiegnitz S: Assay and biochemical characterization of angiotensin I converting enzyme in cerebrospinal fluid . Enzyme 1984;32:12-19. 3. Oksanen V, Fyhrquist F, Somer H, et al: Angiotensin-converting enzyme in cerebrospinal fluid: A new assay . Neurology 1985;35:1220-1223.Crossref 4. Chan Seem CP, Norfolk G, Spokes EG: CSF angiotensin-converting enzyme in neurosarcoidosis . Lancet 1985;1:456-457.Crossref 5. Oksanen V, Fyhrquist F, Grönhagen-Riska C, et al: CSF angiotensin-converting enzyme in neurosarcoidosis . Lancet 1985;1:1050-1051.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Angiotensin-Converting Enzyme in Neurosarcoidosis

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References (5)

Publisher
American Medical Association
Copyright
Copyright © 1987 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1987.00520150005004
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor. —We read with great interest the article by Sethi et al in the June 1986 issue of the Archives.1 We wish to point out another important aspect of neurosarcoidosis that was not discussed by the authors, namely, determination of angiotensin I—converting enzyme (ACE) levels in the cerebrospinal fluid (CSF) of patients with suspected neurosarcoidosis.2-5High levels of CSF ACE may support the diagnosis of neurosarcoidosis even though the serum ACE levels are within the normal range.2,3 Furthermore, monitoring the CSF ACE levels may aid in patient management and follow-up, since CSF ACE levels decrease when the disease is clinically remitted due to corticosteroid therapy.3,5 There is no correlation between the serum and CSF ACE levels in patients with neurosarcoidosis, nor is there any correlation between CSF ACE and CSF total protein or albumin levels in such cases.3 The CSF ACE is most References 1. Sethi KD, El Gammal T, Patel BR, et al: Dural sarcoidosis presenting with transient neurologic symptoms . Arch Neurol 1986;43:595-597.Crossref 2. Schweisfurth H, Schioberg-Schiegnitz S: Assay and biochemical characterization of angiotensin I converting enzyme in cerebrospinal fluid . Enzyme 1984;32:12-19. 3. Oksanen V, Fyhrquist F, Somer H, et al: Angiotensin-converting enzyme in cerebrospinal fluid: A new assay . Neurology 1985;35:1220-1223.Crossref 4. Chan Seem CP, Norfolk G, Spokes EG: CSF angiotensin-converting enzyme in neurosarcoidosis . Lancet 1985;1:456-457.Crossref 5. Oksanen V, Fyhrquist F, Grönhagen-Riska C, et al: CSF angiotensin-converting enzyme in neurosarcoidosis . Lancet 1985;1:1050-1051.Crossref

Journal

Archives of NeurologyAmerican Medical Association

Published: Mar 1, 1987

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