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Cerebrospinal Fluid Ferritin Levels in Screening for Meningism

Cerebrospinal Fluid Ferritin Levels in Screening for Meningism Abstract • To evaluate the potential diagnostic value of the ferritin concentration in cerebrospinal fluid (CSF), measurements were performed with an immunoradiometric assay in 23 control patients and in 65 patients with various neurologic disorders. The geometric mean ferritin level of 3.5 μg/L in controls was approximately 10% of the level in normal serum with an upper cutoff level of 10 μg/L. Only modest elevations in CSF ferritin concentration were observed in patients with viral meningitis and in those with various noninfectious neurologic disorders. On the other hand, marked elevations ranging between 27 and 322 μg/L (geometric mean, 90 μg/L) were observed in patients with bacterial or fungal meningitis. Results of the study indicate that CSF ferritin levels are a valuable adjunct in the early evaluation of patients presenting with meningism. References 1. Halgren R, Terene A, Wide L, et al: Cerebrospinal fluid ferritin in patients with cerebral infarction or bleeding . Acta Neurol Scand 1980;61:384-392.Crossref 2. Sindic CJM, Callet-Cassart D, Cambiaso CL, et al: The clinical relevance of ferritin concentration in the cerebrospinal fluid . J Neurol Neurosurg Psychiatry 1981;44:329-333.Crossref 3. Halgren R, Lundquist G, Sedin G, et al: Cerebrospinal fluid ferritin in newborn infants . Acta Paediatr Scand 1982;71:97-102.Crossref 4. Skikne BS, Linpisarn S, Cook JD: An evaluation of monoclonal antibodies for serum ferritin measurements . Am J Clin Nutr 1984;40:346-350. 5. Miles LEM, Lipschitz DA, Bieber CP, et al: Measurement of serum ferritin by a 2-site immunoradiometric assay . Anal Biochem 1974;61:209-224.Crossref 6. Worwood M, Cragg SJ, Wagstaff M, et al: Binding of human serum ferritin to concanavalin A . Clin Sci 1979;56:83-87. 7. Vicente V, Gonzales M, Lopez Borrasca A: Cerebrospinal fluid levels, β2-microglobulin and ferritin in lymphoproliferative disorders . Acta Paediatr Scand 1982;71:325-326.Crossref 8. Dillman E, Lopez-Karpovitch X, Alvarez Hernandez X, et al: Ferritin levels in cerebrospinal fluid (CSF) as an indicator of meningeal leukemia , in Saltman P, Hegenauer J (eds): The Biochemistry and Physiology of Iron . New York, Elsevier Biomedical, 1982, pp 411-412. 9. Lipschitz DA, Cook JD, Finch CA: Ferritin in formed blood elements . Proc Soc Exp Biol Med 1975;148:358-364.Crossref 10. Revenant MC: Sandwich enzyme immunoassay for serum ferritin with polypropylene test tubes as the solid phase . Clin Chem 1983;29:681-683. 11. Iacobello C, Ghielmi S, Belloli S, et al: Use of a reference standard to improve the accuracy and precision of seven kits for determination of ferritin in serum . Clin Chem 1984;30:298-301. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Cerebrospinal Fluid Ferritin Levels in Screening for Meningism

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References (13)

Publisher
American Medical Association
Copyright
Copyright © 1986 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1986.00520120041014
Publisher site
See Article on Publisher Site

Abstract

Abstract • To evaluate the potential diagnostic value of the ferritin concentration in cerebrospinal fluid (CSF), measurements were performed with an immunoradiometric assay in 23 control patients and in 65 patients with various neurologic disorders. The geometric mean ferritin level of 3.5 μg/L in controls was approximately 10% of the level in normal serum with an upper cutoff level of 10 μg/L. Only modest elevations in CSF ferritin concentration were observed in patients with viral meningitis and in those with various noninfectious neurologic disorders. On the other hand, marked elevations ranging between 27 and 322 μg/L (geometric mean, 90 μg/L) were observed in patients with bacterial or fungal meningitis. Results of the study indicate that CSF ferritin levels are a valuable adjunct in the early evaluation of patients presenting with meningism. References 1. Halgren R, Terene A, Wide L, et al: Cerebrospinal fluid ferritin in patients with cerebral infarction or bleeding . Acta Neurol Scand 1980;61:384-392.Crossref 2. Sindic CJM, Callet-Cassart D, Cambiaso CL, et al: The clinical relevance of ferritin concentration in the cerebrospinal fluid . J Neurol Neurosurg Psychiatry 1981;44:329-333.Crossref 3. Halgren R, Lundquist G, Sedin G, et al: Cerebrospinal fluid ferritin in newborn infants . Acta Paediatr Scand 1982;71:97-102.Crossref 4. Skikne BS, Linpisarn S, Cook JD: An evaluation of monoclonal antibodies for serum ferritin measurements . Am J Clin Nutr 1984;40:346-350. 5. Miles LEM, Lipschitz DA, Bieber CP, et al: Measurement of serum ferritin by a 2-site immunoradiometric assay . Anal Biochem 1974;61:209-224.Crossref 6. Worwood M, Cragg SJ, Wagstaff M, et al: Binding of human serum ferritin to concanavalin A . Clin Sci 1979;56:83-87. 7. Vicente V, Gonzales M, Lopez Borrasca A: Cerebrospinal fluid levels, β2-microglobulin and ferritin in lymphoproliferative disorders . Acta Paediatr Scand 1982;71:325-326.Crossref 8. Dillman E, Lopez-Karpovitch X, Alvarez Hernandez X, et al: Ferritin levels in cerebrospinal fluid (CSF) as an indicator of meningeal leukemia , in Saltman P, Hegenauer J (eds): The Biochemistry and Physiology of Iron . New York, Elsevier Biomedical, 1982, pp 411-412. 9. Lipschitz DA, Cook JD, Finch CA: Ferritin in formed blood elements . Proc Soc Exp Biol Med 1975;148:358-364.Crossref 10. Revenant MC: Sandwich enzyme immunoassay for serum ferritin with polypropylene test tubes as the solid phase . Clin Chem 1983;29:681-683. 11. Iacobello C, Ghielmi S, Belloli S, et al: Use of a reference standard to improve the accuracy and precision of seven kits for determination of ferritin in serum . Clin Chem 1984;30:298-301.

Journal

Archives of Neurology – American Medical Association

Published: Dec 1, 1986

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